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Neuroscience

D-Index
69
Citations
46717
World Ranking
2567
National Ranking
1210

Biology and Biochemistry

D-Index
69
Citations
46781
World Ranking
7203
National Ranking
3302

Overview

Albert R. La Spada is affiliated with the University of California, Irvine in the United States. Their research primarily spans several fields including Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. Within these main disciplines, their work is further specialized in subfields such as Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Genetics, and Epidemiology.

The research topics addressed by Albert R. La Spada focus significantly on Genetic Neurodegenerative Diseases, Mitochondrial Function and Pathology, Amyotrophic Lateral Sclerosis Research, RNA Research and Splicing, Neurogenetic and Muscular Disorders Research, Muscle Physiology and Disorders, and Neuroinflammation and Neurodegeneration Mechanisms.

Albert R. La Spada has contributed to several recent scientific papers, which include:

  • Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72, 2020, Nature Neuroscience
  • Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4, 2022, Nature
  • Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors, 2020, PLoS Genetics
  • Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders, 2023, Nature Communications
  • Revisiting Glutamate Excitotoxicity in Amyotrophic Lateral Sclerosis and Age-Related Neurodegeneration, 2024, International Journal of Molecular Sciences

The scientist collaborates frequently with peers such as Frederick J. Arnold, Craig L. Bennett, Bryce L. Sopher, Anastasia Gromova, and Paweł M. Świtoński.

Their publications are frequently found in venues like bioRxiv (Cold Spring Harbor Laboratory), Acta Neuropathologica Communications, Nature, Cell Reports, and Science Advances, indicating a broad dissemination of their scientific contributions across multiple reputed outlets.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy.

    Albert R. La Spada;Elizabeth M Wilson;Dennis B Lubahn;A. E Harding

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration

    Patrick Weydt;Victor V. Pineda;Anne E. Torrence;Randell T. Libby

  • ALS motor phenotype heterogeneity, focality, and spread

    Unknown

  • Repeat expansion disease: progress and puzzles in disease pathogenesis.

    Albert R. La Spada;Albert R. La Spada;J. Paul Taylor

  • Converging pathways in neurodegeneration, from genetics to mechanisms.

    Li Gan;Li Gan;Mark R. Cookson;Leonard Petrucelli;Albert R. La Spada

  • PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

    Taiji Tsunemi;Travis D. Ashe;Bradley E. Morrison;Kathryn R. Soriano

  • A simple composite phenotype scoring system for evaluating mouse models of cerebellar ataxia.

    Stephan J. Guyenet;Stephanie A. Furrer;Vincent M. Damian;Travis D. Baughan

  • Fasting activates Fatty Acid Oxidation to enhance intestinal stem cell function during homeostasis and aging

    Maria M. Mihaylova;Chia Wei Cheng;Chia Wei Cheng;Amanda Q. Cao;Surya Tripathi

  • Purkinje cell degeneration (pcd) Phenotypes Caused by Mutations in the Axotomy-Induced Gene, Nna1

    Angeles Fernandez-Gonzalez;Albert R. La Spada;Jason Treadaway;Jason C. Higdon

  • Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

    Ruth Luthi-Carter;Andrew D. Strand;Sarah A. Hanson;Charles Kooperberg

  • Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7.

    Albert R. La Spada;Ying Hui Fu;Bryce L. Sopher;Randell T. Libby

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration

    Vikas B. Palhan;Shiming Chen;Guang-Hua Peng;Agneta Tjernberg

  • Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport.

    Sara K Custer;Gwenn A Garden;Nishi Gill;Udo Rueb

  • Trinucleotide repeat expansion in neurological disease.

    Albert R. La Spada;Henry L. Paulson;Kenneth H. Fischbeck

  • Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72.

    Qiang Zhu;Jie Jiang;Jie Jiang;Tania F. Gendron;Melissa McAlonis-Downes

  • Peripheral Androgen Receptor Gene Suppression Rescues Disease in Mouse Models of Spinal and Bulbar Muscular Atrophy

    Andrew P. Lieberman;Zhigang Yu;Sue Murray;Raechel Peralta

  • Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration.

    Bryce L. Sopher;Patrick S. Thomas;Michelle A. Lafevre-Bernt;Ida E. Holm

Frequent Co-Authors

Gwenn A. Garden
Gwenn A. Garden University of North Carolina at Chapel Hill
Lisa M. Ellerby
Lisa M. Ellerby Buck Institute for Research on Aging
J. Paul Taylor
J. Paul Taylor St. Jude Children's Research Hospital
Eliezer Masliah
Eliezer Masliah National Institutes of Health
Don W. Cleveland
Don W. Cleveland University of California, San Diego
Louis J. Ptáček
Louis J. Ptáček University of California, San Francisco
Evelina Gatti
Evelina Gatti Aix-Marseille University
Kenneth H. Fischbeck
Kenneth H. Fischbeck National Institutes of Health
Sergio Lavandero
Sergio Lavandero University of Chile
Shazib Pervaiz
Shazib Pervaiz National University of Singapore

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