What is he best known for?
The fields of study he is best known for:
Neurodegeneration, Genetics, Neuroscience, Spinal and bulbar muscular atrophy and Huntington's disease are his primary areas of study.
His research on Neurodegeneration also deals with topics like
- Cell biology and related TFEB and Polyglutamine tract,
- Autophagy which intersects with area such as Transactivation.
His research investigates the connection between Genetics and topics such as Disease that intersect with problems in Atrophy.
His Neuroscience study incorporates themes from Phenotype, Neurotoxicity, Autophagosome maturation and Autophagy-Related Protein 7.
His Huntington's disease course of study focuses on Molecular biology and Regulation of gene expression.
The various areas that Albert R. La Spada examines in his Autophagosome study include MAP1LC3B and Chaperone-mediated autophagy.
His most cited work include:
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (4170 citations)
- Guidelines for the use and interpretation of assays for monitoring autophagy (3242 citations)
- Guidelines for the use and interpretation of assays for monitoring autophagy (3242 citations)
What are the main themes of his work throughout his whole career to date?
Albert R. La Spada mostly deals with Cell biology, Neurodegeneration, Neuroscience, Genetics and Spinocerebellar ataxia.
His Cell biology research incorporates elements of Autophagy, Neurotoxicity, Huntingtin and Transgene.
His Autophagy study combines topics from a wide range of disciplines, such as Proteostasis and Programmed cell death.
The concepts of his Neurodegeneration study are interwoven with issues in Pathogenesis, Huntington's disease, Purkinje cell, Genetically modified mouse and Mitochondrial biogenesis.
His Neuroscience research includes elements of Amyotrophic lateral sclerosis and Disease.
In Spinocerebellar ataxia, Albert R. La Spada works on issues like Ataxin 7, which are connected to Molecular biology, Cleavage and Retinal degeneration.
He most often published in these fields:
- Cell biology (42.71%)
- Neurodegeneration (37.50%)
- Neuroscience (32.81%)
What were the highlights of his more recent work (between 2018-2021)?
- Cell biology (42.71%)
- Neuroscience (32.81%)
- Spinocerebellar ataxia (21.35%)
In recent papers he was focusing on the following fields of study:
The scientist’s investigation covers issues in Cell biology, Neuroscience, Spinocerebellar ataxia, Autophagy and Pathology.
The Cell biology study combines topics in areas such as Transgene, Neurotoxicity, Transcription and Neuroprotection.
His work deals with themes such as Huntingtin, RNA polymerase II and DNA repair, which intersect with Transcription.
In his study, Neurodegeneration is inextricably linked to Amyotrophic lateral sclerosis, which falls within the broad field of Neuroscience.
Albert R. La Spada has included themes like Let-7 MicroRNA, Clinical phenotype, RNA metabolism and Machado–Joseph disease in his Autophagy study.
Albert R. La Spada interconnects Ataxia and FMR1 in the investigation of issues within Pathology.
Between 2018 and 2021, his most popular works were:
- TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities. (52 citations)
- Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72. (44 citations)
- Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72. (44 citations)
In his most recent research, the most cited papers focused on:
His primary scientific interests are in Cell biology, Autophagy, Amyotrophic lateral sclerosis, Neuroscience and Mitochondrion.
His studies deal with areas such as Neurotoxicity, Spinocerebellar ataxia, RNA polymerase II, Transcription and Sirtuin as well as Cell biology.
His Autophagy study combines topics in areas such as RNA, Phenotype, Messenger RNA, Gene and Transcriptome.
His biological study spans a wide range of topics, including Transgene, C9orf72 Protein, C9orf72, Trinucleotide repeat expansion and Endogeny.
Neuroscience is closely attributed to Genetically modified mouse in his study.
His Mitochondrion study also includes
- Purkinje cell which connect with Axoplasmic transport, Parkin and Motility,
- Tubulin which intersects with area such as Neurodegeneration.
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