World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
11878
World Ranking
8883
National Ranking
79

Overview

Avigdor Shafferman is affiliated with the Israel Institute for Biological Research in Israel. Their research activity spans multiple areas within biochemistry, genetics, and molecular biology, with a focus on both basic and applied scientific questions related to bacterial genetics and pharmacology.

Their recent publications demonstrate active engagement with topics such as bacterial stress responses and enzymatic inhibition relevant to neurodegenerative diseases. Two notable papers include:

  • Comparative Analysis of the Global Transcriptomic Response to Oxidative Stress of Bacillus anthracis htrA-Disrupted and Parental Wild Type Strains, 2020, published in Microorganisms
  • Inhibition of Human Acetyl- and Butyrylcholinesterase by Novel Carbamates of (−)- and (+)-Tetrahydrofurobenzofuran and Methanobenzodioxepine, 2020, published in OPAL (Open@LaTrobe) (La Trobe University)

Their body of work integrates several principal topics, including:

  • Bacillus and Francisella bacterial research
  • Bacteriophages and microbial interactions
  • Bacterial Genetics and Biotechnology
  • Cholinesterase and Neurodegenerative Diseases
  • Chemical synthesis and alkaloids
  • Analytical Methods in Pharmaceuticals

Areas of specialization can be divided into main fields and subfields. The main fields of study include Biochemistry, Genetics and Molecular Biology, and Chemistry. Within these, subfields addressed comprise Molecular Biology, Ecology, Genetics, Pharmacology, and Organic Chemistry.

Shafferman frequently collaborates with a number of researchers, indicating a network of partnerships in related disciplines. Their frequent co-authors include:

  • Galia Zaide
  • Uri Elia
  • Inbar Cohen-Gihon
  • Ma'ayan Israeli
  • Shahar Rotem

Publication venues for their work reflect a multidisciplinary approach, with articles appearing in journals such as Microorganisms and OPAL (Open@LaTrobe) (La Trobe University), showcasing contributions to microbial studies as well as chemical and pharmacological research domains.

Best Publications

  • Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket.

    A Ordentlich;D Barak;C Kronman;Y Flashner

  • Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

    Gitay Kryger;Michal Harel;Kurt Giles;Lilly Toker

  • Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.

    Charles B. Millard;Gitay Kryger;Arie Ordentlich;Harry M. Greenblatt

  • Search for correlates of protective immunity conferred by anthrax vaccine.

    Shaul Reuveny;Moshe D. White;Yaakov Y. Adar;Yaron Kafri

  • Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center.

    A Shafferman;B Velan;A Ordentlich;C Kronman

  • A Phase I Evaluation of the Safety and Immunogenicity of Vaccination with Recombinant gp160 in Patients with Early Human Immunodeficiency Virus Infection

    Redfield Rr;Birx Dl;Ketter N;Tramont E

  • Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding.

    A Shafferman;C Kronman;Y Flashner;M Leitner

  • Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.

    D. Barak;C. Kronman;A. Ordentlich;N. Ariel

  • Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre.

    Avigdor Shafferman;Arie Ordentlich;Dov Barak;Dana Stein

  • Reaction Products of Acetylcholinesterase and VX Reveal a Mobile Histidine in the Catalytic Triad

    Charles B. Millard;Gertraud Koellner;Arie Ordentlich;Avigdor Shafferman

  • Attenuated Nontoxinogenic and Nonencapsulated Recombinant Bacillus anthracis Spore Vaccines Protect against Anthrax

    S. Cohen;I. Mendelson;Z. Altboum;D. Kobiler

  • Functional Characteristics of the Oxyanion Hole in Human Acetylcholinesterase

    Arie Ordentlich;Dov Barak;Chanoch Kronman;Naomi Ariel

  • Multidisciplinary Approaches to Cholinesterase Functions

    Avigdor Shafferman;Baruch Velan

  • Search for potential vaccine candidate open reading frames in the Bacillus anthracis virulence plasmid pXO1: in silico and in vitro screening.

    N. Ariel;A. Zvi;H. Grosfeld;O. Gat

  • Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses

    Anat Zvi;Naomi Ariel;John Fulkerson;Jerald C Sadoff

  • Differential Proteomic Analysis of the Bacillus anthracis Secretome: Distinct Plasmid and Chromosome CO2-Dependent Cross Talk Mechanisms Modulate Extracellular Proteolytic Activities

    Theodor Chitlaru;Orit Gat;Yael Gozlan;Naomi Ariel

  • The Architecture of Human Acetylcholinesterase Active Center Probed by Interactions with Selected Organophosphate Inhibitors

    Arie Ordentlich;Dov Barak;Chanoch Kronman;Naomi Ariel

  • Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase.

    Arie Ordentlich;Dov Barak;Chanoch Kronman;Naomi Ariel

  • Identification of In Vivo-Expressed Immunogenic Proteins by Serological Proteome Analysis of the Bacillus anthracis Secretome

    Theodor Chitlaru;Orit Gat;Haim Grosfeld;Itzhak Inbar

  • Genome-Based Bioinformatic Selection of Chromosomal Bacillus anthracis Putative Vaccine Candidates Coupled with Proteomic Identification of Surface-Associated Antigens

    N. Ariel;A. Zvi;K. S. Makarova;T. Chitlaru

Frequent Co-Authors

Baruch Velan
Baruch Velan Sheba Medical Center
Joel L. Sussman
Joel L. Sussman Weizmann Institute of Science
Israel Silman
Israel Silman Weizmann Institute of Science
Donald S. Burke
Donald S. Burke University of Pittsburgh
Michal Harel
Michal Harel Weizmann Institute of Science
Palmer Taylor
Palmer Taylor University of California, San Diego
Mark G. Lewis
Mark G. Lewis Walter Reed Army Institute of Research
Raoul E. Benveniste
Raoul E. Benveniste National Institutes of Health
Gal Markel
Gal Markel Tel Aviv University
Francine E. McCutchan
Francine E. McCutchan Columbia University

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