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Chemistry

D-Index
52
Citations
8719
World Ranking
13611
National Ranking
556

Overview

Florian Nachon is affiliated with the Centre national de la recherche scientifique (CNRS) in France. Their research primarily focuses on the interface of medicinal chemistry and neurodegenerative diseases, particularly within the field of medicine. A significant portion of their scholarly contributions is centered on cholinesterase and its role in neurodegenerative disorders, computational drug discovery methods, and pesticide-related toxicity.

Their publication record includes several papers addressing the development and evaluation of multi-target-directed ligands, enzyme inhibitors, and molecular insights relevant to Alzheimer's disease and neuroprotection. Notable recent publications include:

  • Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease, 2021, Journal of Medicinal Chemistry
  • Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice, 2020, Journal of Medicinal Chemistry
  • N-alkylpiperidine carbamates as potential anti-Alzheimer's agents, 2020, European Journal of Medicinal Chemistry
  • 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases, 2023, Acta Pharmaceutica Sinica B
  • A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides, 2020, Molecules

The scientist frequently collaborates with peers across pharmacology, computational approaches, and chemistry. Among their frequent co-authors are Xavier Brazzolotto, José Dias, Damijan Knez, Stanislav Gobec, and Fabien Chantegreil.

Research dissemination often occurs in journals specializing in medicinal and chemical studies. Their most common venues include the European Journal of Medicinal Chemistry, Journal of Medicinal Chemistry, Chemico-Biological Interactions, Archives of Toxicology, and Molecules.

Florian Nachon's research spans multiple subfields, including pharmacology, computational theory and mathematics, plant science, molecular biology, and organic chemistry. The main research topics covered by their work are:

  • Cholinesterase and Neurodegenerative Diseases
  • Computational Drug Discovery Methods
  • Pesticide Exposure and Toxicity
  • Chemical Synthesis and Alkaloids
  • Neuroscience and Neuropharmacology Research
  • Insect and Pesticide Research
  • Environmental Toxicology and Ecotoxicology

The interdisciplinary nature of their work intersects chemistry, biology, and toxicology with a focus on therapeutic targets related to Alzheimer's disease and neurodegeneration, along with studies on enzyme inhibition and environmental toxicology.

Best Publications

  • Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.

    Yvain Nicolet;Oksana Lockridge;Patrick Masson;Juan C. Fontecilla-Camps

  • Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.

    Florian Nachon;Eugénie Carletti;Cyril Ronco;Marie Trovaslet

  • Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

    Guillaume Mercey;Guillaume Mercey;Tristan Verdelet;Tristan Verdelet;Julien Renou;Julien Renou;Maria Kliachyna

  • Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study.

    Terrone L Rosenberry;Xavier Brazzolotto;Ian R Macdonald;Marielle Wandhammer

  • Progress in the development of enzyme-based nerve agent bioscavengers ☆

    Florian Nachon;Xavier Brazzolotto;Marie Trovaslet;Patrick Masson;Patrick Masson

  • Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization.

    Florian Nachon;Yvain Nicolet;Nathalie Viguié;Patrick Masson

  • Development of an in-vivo active reversible butyrylcholinesterase inhibitor

    Urban Košak;Boris Brus;Damijan Knez;Roman Šink

  • The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

    Urban Košak;Boris Brus;Damijan Knez;Simon Žakelj

  • Discovery and structure-activity relationships of a highly selective butyrylcholinesterase inhibitor by structure-based virtual screening

    Satish N. Dighe;Girdhar Singh Deora;Eugenio De la Mora;Florian Nachon

  • Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation.

    Eugénie Carletti;He Li;Bin Li;Fredrik Ekström

  • First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.

    Guillaume Mercey;Guillaume Mercey;Tristan Verdelet;Tristan Verdelet;Géraldine Saint-André;Emilie Gillon

  • Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning

    Patrick Masson;Florian Nachon

  • Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging

    Florian Nachon;Oluwatoyin A. Asojo;Gloria E. O. Borgstahl;Patrick Masson

  • Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation.

    Eugénie Carletti;Jacques-Philippe Colletier;Florine Dupeux;Marie Trovaslet

  • Human butyrylcholinesterase produced in insect cells: huprine‐based affinity purification and crystal structure

    Xavier Brazzolotto;Marielle Wandhammer;Cyril Ronco;Marie Trovaslet

  • Binding and Hydrolysis of Soman by Human Serum Albumin

    Bin Li;Florian Nachon;Marie Thérèse Froment;Laurent Verdier

  • Structure, activities and biomedical applications of human butyrylcholinesterase.

    Patrick Masson;Eugénie Carletti;Florian Nachon

  • Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease.

    Michele Rossi;Michela Freschi;Luciana de Camargo Nascente;Alessandra Salerno

  • Crystallographic Snapshots of Nonaged and Aged Conjugates of Soman with Acetylcholinesterase, and of a Ternary Complex of the Aged Conjugate with Pralidoxime.

    Benoît Sanson;Florian Nachon;Jacques-Philippe Colletier;Marie-Thérèse Froment

  • Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.

    Katarina Chalupova;Jan Korabecny;Manuela Bartolini;Barbara Monti

  • Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase

    Maria Kliachyna;Gianluca Santoni;Valentin Nussbaum;Julien Renou

  • Exposure to tri-o-cresyl phosphate detected in jet airplane passengers.

    Mariya Liyasova;Bin Li;Lawrence M. Schopfer;Florian Nachon

Frequent Co-Authors

Patrick Masson
Patrick Masson Kazan Federal University
Pierre-Yves Renard
Pierre-Yves Renard University of Rouen
Oksana Lockridge
Oksana Lockridge University of Nebraska Medical Center
Stanislav Gobec
Stanislav Gobec University of Ljubljana
Janko Kos
Janko Kos University of Ljubljana
Israel Silman
Israel Silman Weizmann Institute of Science
Kamil Kuca
Kamil Kuca University of Hradec Králové
Joel L. Sussman
Joel L. Sussman Weizmann Institute of Science
Franz Worek
Franz Worek Ludwig-Maximilians-Universität München
Juan C. Fontecilla-Camps
Juan C. Fontecilla-Camps Centre national de la recherche scientifique, CNRS

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