World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
52
Citations
8719
World Ranking
13609
National Ranking
556

Florian Nachon publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Florian Nachon sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 238 publications — 46th percentile

46% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Florian Nachon D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Florian Nachon sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 52 D-Index — 26th percentile

26% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Overview

Florian Nachon is affiliated with the Centre national de la recherche scientifique (CNRS) in France. Their research primarily focuses on the interface of medicinal chemistry and neurodegenerative diseases, particularly within the field of medicine. A significant portion of their scholarly contributions is centered on cholinesterase and its role in neurodegenerative disorders, computational drug discovery methods, and pesticide-related toxicity.

Their publication record includes several papers addressing the development and evaluation of multi-target-directed ligands, enzyme inhibitors, and molecular insights relevant to Alzheimer's disease and neuroprotection. Notable recent publications include:

  • Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease, 2021, Journal of Medicinal Chemistry
  • Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice, 2020, Journal of Medicinal Chemistry
  • N-alkylpiperidine carbamates as potential anti-Alzheimer's agents, 2020, European Journal of Medicinal Chemistry
  • 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases, 2023, Acta Pharmaceutica Sinica B
  • A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides, 2020, Molecules

The scientist frequently collaborates with peers across pharmacology, computational approaches, and chemistry. Among their frequent co-authors are Xavier Brazzolotto, José Dias, Damijan Knez, Stanislav Gobec, and Fabien Chantegreil.

Research dissemination often occurs in journals specializing in medicinal and chemical studies. Their most common venues include the European Journal of Medicinal Chemistry, Journal of Medicinal Chemistry, Chemico-Biological Interactions, Archives of Toxicology, and Molecules.

Florian Nachon's research spans multiple subfields, including pharmacology, computational theory and mathematics, plant science, molecular biology, and organic chemistry. The main research topics covered by their work are:

  • Cholinesterase and Neurodegenerative Diseases
  • Computational Drug Discovery Methods
  • Pesticide Exposure and Toxicity
  • Chemical Synthesis and Alkaloids
  • Neuroscience and Neuropharmacology Research
  • Insect and Pesticide Research
  • Environmental Toxicology and Ecotoxicology

The interdisciplinary nature of their work intersects chemistry, biology, and toxicology with a focus on therapeutic targets related to Alzheimer's disease and neurodegeneration, along with studies on enzyme inhibition and environmental toxicology.

Best Publications

  • Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.

    Yvain Nicolet;Oksana Lockridge;Patrick Masson;Juan C. Fontecilla-Camps

  • Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.

    Florian Nachon;Eugénie Carletti;Cyril Ronco;Marie Trovaslet

  • Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

    Guillaume Mercey;Guillaume Mercey;Tristan Verdelet;Tristan Verdelet;Julien Renou;Julien Renou;Maria Kliachyna

  • Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study.

    Terrone L Rosenberry;Xavier Brazzolotto;Ian R Macdonald;Marielle Wandhammer

  • Progress in the development of enzyme-based nerve agent bioscavengers ☆

    Florian Nachon;Xavier Brazzolotto;Marie Trovaslet;Patrick Masson;Patrick Masson

  • Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization.

    Florian Nachon;Yvain Nicolet;Nathalie Viguié;Patrick Masson

  • Development of an in-vivo active reversible butyrylcholinesterase inhibitor

    Urban Košak;Boris Brus;Damijan Knez;Roman Šink

  • The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

    Urban Košak;Boris Brus;Damijan Knez;Simon Žakelj

  • Discovery and structure-activity relationships of a highly selective butyrylcholinesterase inhibitor by structure-based virtual screening

    Satish N. Dighe;Girdhar Singh Deora;Eugenio De la Mora;Florian Nachon

  • Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation.

    Eugénie Carletti;He Li;Bin Li;Fredrik Ekström

  • First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.

    Guillaume Mercey;Guillaume Mercey;Tristan Verdelet;Tristan Verdelet;Géraldine Saint-André;Emilie Gillon

  • Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning

    Patrick Masson;Florian Nachon

  • Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging

    Florian Nachon;Oluwatoyin A. Asojo;Gloria E. O. Borgstahl;Patrick Masson

  • Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation.

    Eugénie Carletti;Jacques-Philippe Colletier;Florine Dupeux;Marie Trovaslet

  • Human butyrylcholinesterase produced in insect cells: huprine‐based affinity purification and crystal structure

    Xavier Brazzolotto;Marielle Wandhammer;Cyril Ronco;Marie Trovaslet

  • Binding and Hydrolysis of Soman by Human Serum Albumin

    Bin Li;Florian Nachon;Marie Thérèse Froment;Laurent Verdier

  • Structure, activities and biomedical applications of human butyrylcholinesterase.

    Patrick Masson;Eugénie Carletti;Florian Nachon

  • Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease.

    Michele Rossi;Michela Freschi;Luciana de Camargo Nascente;Alessandra Salerno

  • Crystallographic Snapshots of Nonaged and Aged Conjugates of Soman with Acetylcholinesterase, and of a Ternary Complex of the Aged Conjugate with Pralidoxime.

    Benoît Sanson;Florian Nachon;Jacques-Philippe Colletier;Marie-Thérèse Froment

  • Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.

    Katarina Chalupova;Jan Korabecny;Manuela Bartolini;Barbara Monti

  • Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase

    Maria Kliachyna;Gianluca Santoni;Valentin Nussbaum;Julien Renou

  • Exposure to tri-o-cresyl phosphate detected in jet airplane passengers.

    Mariya Liyasova;Bin Li;Lawrence M. Schopfer;Florian Nachon

Frequent Co-Authors

Patrick Masson
Patrick Masson Kazan Federal University
Pierre-Yves Renard
Pierre-Yves Renard University of Rouen
Oksana Lockridge
Oksana Lockridge University of Nebraska Medical Center
Stanislav Gobec
Stanislav Gobec University of Ljubljana
Janko Kos
Janko Kos University of Ljubljana
Israel Silman
Israel Silman Weizmann Institute of Science
Kamil Kuca
Kamil Kuca University of Hradec Králové
Joel L. Sussman
Joel L. Sussman Weizmann Institute of Science
Franz Worek
Franz Worek Ludwig-Maximilians-Universität München
Juan C. Fontecilla-Camps
Juan C. Fontecilla-Camps Centre national de la recherche scientifique, CNRS

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