What is he best known for?
The fields of study he is best known for:
- Enzyme
- Amino acid
- Biochemistry
Florian Nachon mainly focuses on Acetylcholinesterase, Butyrylcholinesterase, Stereochemistry, Nerve agent and Cholinesterase.
His work carried out in the field of Butyrylcholinesterase brings together such families of science as Hydrolase, Drug discovery and Active site.
His Stereochemistry study combines topics from a wide range of disciplines, such as Tabun, Oxime and Tacrine.
His Nerve agent research incorporates elements of Soman, Adduct, Organophosphate poisoning, Aché and Pharmacology.
His Cholinesterase research focuses on subjects like Oxyanion hole, which are linked to Organophosphorus compound and Active center.
Many of his research projects under Enzyme are closely connected to Torpedo with Torpedo, tying the diverse disciplines of science together.
His most cited work include:
- Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products. (554 citations)
- Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents (208 citations)
- Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase. (185 citations)
What are the main themes of his work throughout his whole career to date?
His scientific interests lie mostly in Acetylcholinesterase, Butyrylcholinesterase, Stereochemistry, Biochemistry and Nerve agent.
His work on Tabun as part of general Acetylcholinesterase research is frequently linked to Torpedo, thereby connecting diverse disciplines of science.
His study in Butyrylcholinesterase is interdisciplinary in nature, drawing from both Cholinergic, Cholinesterase, Neuroprotection, Adduct and Chromatography.
His research integrates issues of Soman, Hydrolase, Catalysis, Active site and Substrate in his study of Stereochemistry.
The study incorporates disciplines such as Combinatorial chemistry and Pralidoxime in addition to Nerve agent.
In his study, In vivo is strongly linked to In vitro, which falls under the umbrella field of Enzyme.
He most often published in these fields:
- Acetylcholinesterase (51.32%)
- Butyrylcholinesterase (48.68%)
- Stereochemistry (38.82%)
What were the highlights of his more recent work (between 2015-2021)?
- Acetylcholinesterase (51.32%)
- Butyrylcholinesterase (48.68%)
- Pharmacology (15.13%)
In recent papers he was focusing on the following fields of study:
His primary areas of study are Acetylcholinesterase, Butyrylcholinesterase, Pharmacology, Nerve agent and Biochemistry.
Florian Nachon combines subjects such as Oxime, Biophysics and Stereochemistry with his study of Acetylcholinesterase.
His Conformational change study, which is part of a larger body of work in Stereochemistry, is frequently linked to Solvation shell, bridging the gap between disciplines.
His Butyrylcholinesterase research integrates issues from Cholinergic, Cholinesterase, Hydrolase, Neuroprotection and Drug discovery.
His Nerve agent research includes elements of Bifunctional, Pralidoxime, In vitro and Combinatorial chemistry.
His research in the fields of Structure–activity relationship, Catalysis and Endogeny overlaps with other disciplines such as Prokaryotic expression.
Between 2015 and 2021, his most popular works were:
- Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning (66 citations)
- Discovery and structure-activity relationships of a highly selective butyrylcholinesterase inhibitor by structure-based virtual screening (61 citations)
- Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study. (56 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Amino acid
- Biochemistry
Florian Nachon mostly deals with Acetylcholinesterase, Butyrylcholinesterase, Biochemistry, Oxime and Stereochemistry.
His study looks at the relationship between Acetylcholinesterase and topics such as Biophysics, which overlap with Active site.
His Butyrylcholinesterase research is multidisciplinary, incorporating perspectives in Cholinergic, Cholinesterase, Hydrolase, Neuroprotection and Drug discovery.
His Agonist, σ1 receptor, Indole test and Receptor study in the realm of Biochemistry interacts with subjects such as Torpedo.
His Oxime study integrates concerns from other disciplines, such as Cyclosarin, Tabun, Sarin, Paraoxon and Pralidoxime.
His work deals with themes such as Covalent bond and Protein structure, which intersect with Stereochemistry.
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