Florian Nachon mainly focuses on Acetylcholinesterase, Butyrylcholinesterase, Stereochemistry, Nerve agent and Cholinesterase. His work carried out in the field of Butyrylcholinesterase brings together such families of science as Hydrolase, Drug discovery and Active site. His Stereochemistry study combines topics from a wide range of disciplines, such as Tabun, Oxime and Tacrine.
His Nerve agent research incorporates elements of Soman, Adduct, Organophosphate poisoning, Aché and Pharmacology. His Cholinesterase research focuses on subjects like Oxyanion hole, which are linked to Organophosphorus compound and Active center. Many of his research projects under Enzyme are closely connected to Torpedo with Torpedo, tying the diverse disciplines of science together.
His scientific interests lie mostly in Acetylcholinesterase, Butyrylcholinesterase, Stereochemistry, Biochemistry and Nerve agent. His work on Tabun as part of general Acetylcholinesterase research is frequently linked to Torpedo, thereby connecting diverse disciplines of science. His study in Butyrylcholinesterase is interdisciplinary in nature, drawing from both Cholinergic, Cholinesterase, Neuroprotection, Adduct and Chromatography.
His research integrates issues of Soman, Hydrolase, Catalysis, Active site and Substrate in his study of Stereochemistry. The study incorporates disciplines such as Combinatorial chemistry and Pralidoxime in addition to Nerve agent. In his study, In vivo is strongly linked to In vitro, which falls under the umbrella field of Enzyme.
His primary areas of study are Acetylcholinesterase, Butyrylcholinesterase, Pharmacology, Nerve agent and Biochemistry. Florian Nachon combines subjects such as Oxime, Biophysics and Stereochemistry with his study of Acetylcholinesterase. His Conformational change study, which is part of a larger body of work in Stereochemistry, is frequently linked to Solvation shell, bridging the gap between disciplines.
His Butyrylcholinesterase research integrates issues from Cholinergic, Cholinesterase, Hydrolase, Neuroprotection and Drug discovery. His Nerve agent research includes elements of Bifunctional, Pralidoxime, In vitro and Combinatorial chemistry. His research in the fields of Structure–activity relationship, Catalysis and Endogeny overlaps with other disciplines such as Prokaryotic expression.
Florian Nachon mostly deals with Acetylcholinesterase, Butyrylcholinesterase, Biochemistry, Oxime and Stereochemistry. His study looks at the relationship between Acetylcholinesterase and topics such as Biophysics, which overlap with Active site. His Butyrylcholinesterase research is multidisciplinary, incorporating perspectives in Cholinergic, Cholinesterase, Hydrolase, Neuroprotection and Drug discovery.
His Agonist, σ1 receptor, Indole test and Receptor study in the realm of Biochemistry interacts with subjects such as Torpedo. His Oxime study integrates concerns from other disciplines, such as Cyclosarin, Tabun, Sarin, Paraoxon and Pralidoxime. His work deals with themes such as Covalent bond and Protein structure, which intersect with Stereochemistry.
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Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.
Yvain Nicolet;Oksana Lockridge;Patrick Masson;Juan C. Fontecilla-Camps.
Journal of Biological Chemistry (2003)
Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents
Guillaume Mercey;Guillaume Mercey;Tristan Verdelet;Tristan Verdelet;Julien Renou;Julien Renou;Maria Kliachyna.
Accounts of Chemical Research (2012)
Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.
Florian Nachon;Eugénie Carletti;Cyril Ronco;Marie Trovaslet.
Biochemical Journal (2013)
Progress in the development of enzyme-based nerve agent bioscavengers ☆
Florian Nachon;Xavier Brazzolotto;Marie Trovaslet;Patrick Masson;Patrick Masson.
Chemico-Biological Interactions (2013)
Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization.
Florian Nachon;Yvain Nicolet;Nathalie Viguié;Patrick Masson.
FEBS Journal (2002)
Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation.
Eugénie Carletti;He Li;Bin Li;Fredrik Ekström.
Journal of the American Chemical Society (2008)
Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging
Florian Nachon;Oluwatoyin A. Asojo;Gloria E. O. Borgstahl;Patrick Masson.
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.
Guillaume Mercey;Guillaume Mercey;Tristan Verdelet;Tristan Verdelet;Géraldine Saint-André;Emilie Gillon.
Chemical Communications (2011)
Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation.
Eugénie Carletti;Jacques-Philippe Colletier;Florine Dupeux;Marie Trovaslet.
Journal of Medicinal Chemistry (2010)
Binding and Hydrolysis of Soman by Human Serum Albumin
Bin Li;Florian Nachon;Marie Thérèse Froment;Laurent Verdier.
Chemical Research in Toxicology (2008)
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