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Chemistry

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Overview

Oksana Lockridge is affiliated with the University of Nebraska Medical Center in the United States. Their research spans multiple fields including biochemistry, genetics, molecular biology, medicine, and agricultural and biological sciences. Within these areas, the scientist has contributed extensively to subfields such as pharmacology, plant science, molecular biology, computational theory and mathematics, and insect science.

Their work covers a variety of topics primarily focused on pesticide exposure and toxicity, cholinesterase and neurodegenerative diseases, computational drug discovery methods, insect and pesticide research, blood properties and coagulation, carcinogens and genotoxicity assessment, and environmental studies related to pesticides and herbicides.

Recent publications by Oksana Lockridge include:

  • Review: Organophosphorus toxicants, in addition to inhibiting acetylcholinesterase activity, make covalent adducts on multiple proteins and promote protein crosslinking into high molecular weight aggregates (2023, Chemico-Biological Interactions)
  • Drug and pro-drug substrates and pseudo-substrates of human butyrylcholinesterase (2023, Biochemical Pharmacology)
  • Butyrylcholinesterase in SH-SY5Y human neuroblastoma cells (2022, NeuroToxicology)
  • Human butyrylcholinesterase in Cohn fraction IV-4 purified in a single chromatography step on Hupresin (2023, PLoS ONE)
  • Organophosphorus Pesticides Promote Protein Cross-Linking (2022, Chemical Research in Toxicology)

Oksana Lockridge frequently collaborates with several researchers, including Lawrence M. Schopfer, Patrick Masson, Seda Önder, Özden Tacal, and Marilynn A. Larson. These collaborations have resulted in numerous publications that explore biochemical interactions related to cholinesterase and toxicology.

The scientist's work has been published predominantly in the following venues:

  • Chemico-Biological Interactions
  • PLoS ONE
  • Chemical Research in Toxicology
  • Molecules
  • Analytical Biochemistry

The research output reflects interdisciplinary approaches combining experimental biochemistry, pharmacological studies, and computational methods. Focus areas involve detailed investigations of human butyrylcholinesterase and the impact of organophosphorus compounds, especially in relation to their biochemical mechanisms and neurotoxic effects.

Best Publications

  • Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.

    Yvain Nicolet;Oksana Lockridge;Patrick Masson;Juan C. Fontecilla-Camps

  • Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine

    M. M. Mesulam;A. Guillozet;P. Shaw;A. Levey

  • Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma

    Bin Li;Meghan Sedlacek;Indumathi Manoharan;Rathnam Boopathy

  • Comparison of butyrylcholinesterase and acetylcholinesterase.

    Unknown

  • Differences in active-site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase

    Ashima Saxena;Ann M.G. Redman;Xuliang Jiang;Oksana Lockridge

  • Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses.

    Unknown

  • Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse.

    Bin Li;Judith A. Stribley;Judith A. Stribley;Andreea Ticu;Weihua Xie

  • Postnatal Developmental Delay and Supersensitivity to Organophosphate in Gene-Targeted Mice Lacking Acetylcholinesterase

    Weihua Xie;Judith A. Stribley;Arnaud Chatonnet;Phillip J. Wilder

  • DNA mutation associated with the human butyrylcholinesterase K-variant and its linkage to the atypical variant mutation and other polymorphic sites

    C. F. Bartels;F. S. Jensen;O. Lockridge;A. F.L. Van der Spek

  • Butyrylcholinesterase for protection from organophosphorus poisons; catalytic complexities and hysteretic behavior

    Patrick Masson;Oksana Lockridge

  • Mechanism of action of the flavoenzyme lactate oxidase.

    Oksana Lockridge;Vincent Massey;Patrick A. Sullivan

  • Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine.

    Unknown

  • A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase

    Oksana Lockridge;Renee M. Blong;Patrick Masson;Marie Thérèse Froment

  • An improved cocaine hydrolase: the A328Y mutant of human butyrylcholinesterase is 4-fold more efficient.

    Weihua Xie;Cibby Varkey Altamirano;Cynthia F. Bartels;Robert J. Speirs

  • Pesticides and susceptible populations: people with butyrylcholinesterase genetic variants may be at risk.

    O Lockridge;P Masson

  • Evidence for Nonacetylcholinesterase Targets of Organophosphorus Nerve Agent: Supersensitivity of Acetylcholinesterase Knockout Mouse to VX Lethality

    Ellen G. Duysen;Bin Li;Weihua Xie;Lawrence M. Schopfer

  • Comparison of atypical and usual human serum cholinesterase. Purification, number of active sites, substrate affinity, and turnover number.

    Oksana Lockridge;B. N. La Du

  • Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase.

    Sultan Darvesh;Sultan Darvesh;Katherine V. Darvesh;Robert S. McDonald;Diane Mataija

  • Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase.

    Unknown

  • Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse.

    Ellen G. Duysen;Judith A. Stribley;Debra L. Fry;Steven Heye Hinrichs

  • Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase

    Patrick Masson;Pierre Legrand;Cynthia F. Bartels;Marie Thérese Froment

  • Interchain disulfide bonds and subunit organization in human serum cholinesterase.

    Oksana Lockridge;H. W. Eckerson;B. N. La Du

  • Albumin, a New Biomarker of Organophosphorus Toxicant Exposure, Identified by Mass Spectrometry

    Eric S. Peeples;Lawrence M. Schopfer;Ellen G. Duysen;Reggie Spaulding

  • Re-engineering butyrylcholinesterase as a cocaine hydrolase

    Hong Sun;Yuan Ping Pang;Oksana Lockridge;Stephen Brimijoin

Frequent Co-Authors

Patrick Masson
Patrick Masson Kazan Federal University
Florian Nachon
Florian Nachon Centre national de la recherche scientifique, CNRS
Palmer Taylor
Palmer Taylor University of California, San Diego
Bhupendra P. Doctor
Bhupendra P. Doctor Walter Reed Army Institute of Research
Allan I. Levey
Allan I. Levey Emory University
Vincent Massey
Vincent Massey University of Michigan–Ann Arbor
Hong Peng
Hong Peng Xihua University
Clement E. Furlong
Clement E. Furlong University of Washington
Bruno Mégarbane
Bruno Mégarbane Université Paris Cité

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