What is he best known for?
The fields of study he is best known for:
The scientist’s investigation covers issues in Biochemistry, Acetylcholinesterase, Stereochemistry, Active site and Torpedo.
His Biochemistry study deals with Molecular biology intersecting with Mannose, Cell culture and Acetylcholine receptor.
He has included themes like Biophysics and Acetylcholine, Pharmacology in his Acetylcholinesterase study.
His Stereochemistry research includes elements of Hydrolase, Serine hydrolase, Catalytic triad and Sodium dodecyl sulfate.
The study incorporates disciplines such as Butyrylcholinesterase, Substrate, Enzyme promiscuity, Hydrogen bond and Binding site in addition to Active site.
His Torpedo research incorporates themes from Leucine, Phospholipase C and Tacrine.
His most cited work include:
- Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein (2161 citations)
- The α/β hydrolase fold (1726 citations)
- FoldIndex©: a simple tool to predict whether a given protein sequence is intrinsically unfolded (783 citations)
What are the main themes of his work throughout his whole career to date?
Israel Silman mainly focuses on Acetylcholinesterase, Biochemistry, Stereochemistry, Torpedo and Active site.
As part of one scientific family, Israel Silman deals mainly with the area of Acetylcholinesterase, narrowing it down to issues related to the Acetylcholine, and often Cholinergic.
His Molecular biology research extends to Biochemistry, which is thematically connected.
His Stereochemistry research is multidisciplinary, relying on both Hydrolase, Catalytic triad, Crystal structure, Protein structure and Binding site.
His research integrates issues of Crystallography, Chemical modification and Molecule in his study of Torpedo.
Israel Silman combines subjects such as Covalent bond, Substrate and Molecular dynamics with his study of Active site.
He most often published in these fields:
- Acetylcholinesterase (54.17%)
- Biochemistry (35.90%)
- Stereochemistry (31.09%)
What were the highlights of his more recent work (between 2011-2021)?
- Acetylcholinesterase (54.17%)
- Stereochemistry (31.09%)
- Torpedo (29.49%)
In recent papers he was focusing on the following fields of study:
His primary areas of investigation include Acetylcholinesterase, Stereochemistry, Torpedo, Enzyme and Biochemistry.
As part of his studies on Acetylcholinesterase, Israel Silman often connects relevant subjects like Biophysics.
His Stereochemistry study integrates concerns from other disciplines, such as Hydrolase, Protein structure and Active site.
Specifically, his work in Active site is concerned with the study of Catalytic triad.
His work in Enzyme covers topics such as Directed evolution which are related to areas like Hydrolysis, Catalysis, Substrate and Stereoselectivity.
His work in Binding site tackles topics such as Molecule which are related to areas like Crystallography.
Between 2011 and 2021, his most popular works were:
- Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. (157 citations)
- Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis. (156 citations)
- Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1. (113 citations)
In his most recent research, the most cited papers focused on:
Israel Silman mostly deals with Stereochemistry, Acetylcholinesterase, Hydrolase, Enzyme and Active site.
His research on Stereochemistry often connects related areas such as Crystal structure.
His work carried out in the field of Acetylcholinesterase brings together such families of science as Oxime and Acetylcholine receptor.
His Hydrolase research is multidisciplinary, incorporating perspectives in Protein structure, Enzyme catalysis and Torpedo.
Within one scientific family, he focuses on topics pertaining to Thermostability under Protein structure, and may sometimes address concerns connected to Structure–activity relationship.
His Enzyme study is focused on Biochemistry in general.
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