The scientist’s investigation covers issues in Biochemistry, Acetylcholinesterase, Stereochemistry, Active site and Torpedo. His Biochemistry study deals with Molecular biology intersecting with Mannose, Cell culture and Acetylcholine receptor. He has included themes like Biophysics and Acetylcholine, Pharmacology in his Acetylcholinesterase study.
His Stereochemistry research includes elements of Hydrolase, Serine hydrolase, Catalytic triad and Sodium dodecyl sulfate. The study incorporates disciplines such as Butyrylcholinesterase, Substrate, Enzyme promiscuity, Hydrogen bond and Binding site in addition to Active site. His Torpedo research incorporates themes from Leucine, Phospholipase C and Tacrine.
Israel Silman mainly focuses on Acetylcholinesterase, Biochemistry, Stereochemistry, Torpedo and Active site. As part of one scientific family, Israel Silman deals mainly with the area of Acetylcholinesterase, narrowing it down to issues related to the Acetylcholine, and often Cholinergic. His Molecular biology research extends to Biochemistry, which is thematically connected.
His Stereochemistry research is multidisciplinary, relying on both Hydrolase, Catalytic triad, Crystal structure, Protein structure and Binding site. His research integrates issues of Crystallography, Chemical modification and Molecule in his study of Torpedo. Israel Silman combines subjects such as Covalent bond, Substrate and Molecular dynamics with his study of Active site.
His primary areas of investigation include Acetylcholinesterase, Stereochemistry, Torpedo, Enzyme and Biochemistry. As part of his studies on Acetylcholinesterase, Israel Silman often connects relevant subjects like Biophysics. His Stereochemistry study integrates concerns from other disciplines, such as Hydrolase, Protein structure and Active site.
Specifically, his work in Active site is concerned with the study of Catalytic triad. His work in Enzyme covers topics such as Directed evolution which are related to areas like Hydrolysis, Catalysis, Substrate and Stereoselectivity. His work in Binding site tackles topics such as Molecule which are related to areas like Crystallography.
Israel Silman mostly deals with Stereochemistry, Acetylcholinesterase, Hydrolase, Enzyme and Active site. His research on Stereochemistry often connects related areas such as Crystal structure. His work carried out in the field of Acetylcholinesterase brings together such families of science as Oxime and Acetylcholine receptor.
His Hydrolase research is multidisciplinary, incorporating perspectives in Protein structure, Enzyme catalysis and Torpedo. Within one scientific family, he focuses on topics pertaining to Thermostability under Protein structure, and may sometimes address concerns connected to Structure–activity relationship. His Enzyme study is focused on Biochemistry in general.
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Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein
Joel L. Sussman;Michal Harel;Felix Frolow;Christian Oefner.
The α/β hydrolase fold
David L. Ollis;Eong Cheah;Miroslaw Cygler;Bauke Dijkstra.
Protein Engineering (1992)
FoldIndex©: a simple tool to predict whether a given protein sequence is intrinsically unfolded
Jaime Prilusky;Clifford E. Felder;Tzviya Zeev-Ben-Mordehai;Edwin H. Rydberg.
Function and structure of inherently disordered proteins
A Keith Dunker;Israel Silman;Vladimir N Uversky;Vladimir N Uversky;Joel L Sussman.
Current Opinion in Structural Biology (2008)
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.
Gitay Kryger;Israel Silman;Joel L Sussman.
Structure and Evolution of the Serum Paraoxonase Family of Detoxifying and Anti-Atherosclerotic Enzymes
Michal Harel;Amir Aharoni;Leonid Gaidukov;Boris Brumshtein.
Nature Structural & Molecular Biology (2004)
Relationship between sequence conservation and three‐dimensional structure in a large family of esterases, lipases, and related proteins
Miroslaw Cygler;Joseph D. Schrag;Joel L. Sussman;Michal Harel.
Protein Science (1993)
Acetylcholinesterase: From 3D structure to function
Hay Dvir;Israel Silman;Michal Harel;Terrone L. Rosenberry.
Chemico-Biological Interactions (2010)
Acetylcholinesterase: ‘classical’ and ‘non-classical’ functions and pharmacology
Israel Silman;Joel L Sussman.
Current Opinion in Pharmacology (2005)
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
Mia L. Raves;Michal Harel;Yuan Ping Pang;Israel Silman.
Nature Structural & Molecular Biology (1997)
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