Israel Silman

Overview

Best Publications

• Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein

  Joel L. Sussman;Michal Harel;Felix Frolow;Christian Oefner

  3484
  Citations

• The α/β hydrolase fold

  David L. Ollis;Eong Cheah;Miroslaw Cygler;Bauke Dijkstra

  2792
  Citations

• Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.

  M Harel;I Schalk;L Ehret-Sabatier;F Bouet

  1189
  Citations

• FoldIndex©: a simple tool to predict whether a given protein sequence is intrinsically unfolded

  Jaime Prilusky;Clifford E. Felder;Tzviya Zeev-Ben-Mordehai;Edwin H. Rydberg

  1169
  Citations

• Function and structure of inherently disordered proteins

  A Keith Dunker;Israel Silman;Vladimir N Uversky;Vladimir N Uversky;Joel L Sussman

  1145
  Citations

• Acetylcholinesterase: From 3D structure to function

  Hay Dvir;Israel Silman;Michal Harel;Terrone L. Rosenberry

  926
  Citations

• Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.

  Gitay Kryger;Israel Silman;Joel L Sussman

  923
  Citations

• Structure and Evolution of the Serum Paraoxonase Family of Detoxifying and Anti-Atherosclerotic Enzymes

  Michal Harel;Amir Aharoni;Leonid Gaidukov;Boris Brumshtein

  848
  Citations

• Relationship between sequence conservation and three‐dimensional structure in a large family of esterases, lipases, and related proteins

  Miroslaw Cygler;Joseph D. Schrag;Joel L. Sussman;Michal Harel

  739
  Citations

• Acetylcholinesterase: ‘classical’ and ‘non-classical’ functions and pharmacology

  Israel Silman;Joel L Sussman

  679
  Citations

• Specific chemical and structural damage to proteins produced by synchrotron radiation.

  Martin Weik;Raimond B. G. Ravelli;Gitay Kryger;Sean McSweeney

  636
  Citations

• Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.

  Adi Goldenzweig;Moshe Goldsmith;Shannon E. Hill;Or Gertman

  572
  Citations

• Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.

  Mia L. Raves;Michal Harel;Yuan Ping Pang;Israel Silman

  568
  Citations

• A structural motif of acetylcholinesterase that promotes amyloid β-peptide fibril formation

  G. V. De Ferrari;M. A. Canales;I. Shin;L. M. Weiner

  524
  Citations

• Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system

  Yoseph Shaaltiel;Daniel Bartfeld;Sharon Hashmueli;Gideon Baum

  495
  Citations

• The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase.

  Michal Harel;Daniel M. Quinn;Haridasan K. Nair;Israel Silman

  448
  Citations

• Water-insoluble derivatives of enzymes, antigens, and antibodies.

  Unknown

  430
  Citations

• Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

  Gitay Kryger;Michal Harel;Kurt Giles;Lilly Toker

  417
  Citations

• Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis.

  M Harel;J L Sussman;E Krejci;S Bon

  410
  Citations

• Three‐dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors

  Michal Harel;Gitay Kryger;Terrone L. Rosenberry;William D. Mallender

  408
  Citations

• Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution.

  H.M Greenblatt;G Kryger;T.T Lewis;I Silman

  388
  Citations