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D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
24739
World Ranking
11677
National Ranking
111

Overview

Michal Harel is affiliated with the Weizmann Institute of Science in Israel and has contributed extensively to biomedical research, focusing primarily on cancer and molecular biology. Their work intersects significant areas such as cancer immunotherapy, cancer genomics, and diagnostics, alongside studies on lung cancer treatments and the application of radiomics and machine learning in medical imaging.

Their publication record includes papers spanning topics like metabolic vulnerabilities in cancer, protein interactions at cellular membranes, and plasma proteomic profiling related to cancer treatment responses. Notable publications include:

  • PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria, 2020, Nature Communications
  • Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression, 2021, Cancer Research
  • Phosphoproteomics reveals novel modes of function and inter-relationships among PIKKs in response to genotoxic stress, 2020, The EMBO Journal
  • Longitudinal plasma proteomic profiling of patients with non-small cell lung cancer undergoing immune checkpoint blockade, 2022, Journal for ImmunoTherapy of Cancer
  • Clinical Proteomics of Metastatic Melanoma Reveals Profiles of Organ Specificity and Treatment Resistance, 2021, Clinical Cancer Research

Research topics prominent in their portfolio include:

  • Cancer Immunotherapy and Biomarkers
  • Cancer Genomics and Diagnostics
  • Ferroptosis and cancer prognosis
  • Lung Cancer Research Studies
  • Lung Cancer Treatments and Mutations
  • Radiomics and Machine Learning in Medical Imaging
  • Vaccines and immunoinformatics approaches

Michal Harel has collaborated repeatedly with several researchers, suggesting established working relationships. Some frequent co-authors are:

  • Coren Lahav
  • Adam P. Dicker
  • Yehonatan Elon
  • Yuval Shaked
  • Eyal Jacob

Their publications have appeared in journals and venues that reflect a focus on oncology and clinical research, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Oncology
  • Cancer Research
  • Regular and Young Investigator Award Abstracts
  • Annals of Oncology

The main fields of study featured in Michal Harel's body of work are Medicine and Biochemistry, Genetics and Molecular Biology. Within these broader areas, the subfields include Oncology, Molecular Biology, Pulmonary and Respiratory Medicine, Cancer Research, and Cognitive Neuroscience.

Best Publications

  • Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein

    Joel L. Sussman;Michal Harel;Felix Frolow;Christian Oefner

  • The α/β hydrolase fold

    David L. Ollis;Eong Cheah;Miroslaw Cygler;Bauke Dijkstra

  • Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.

    M Harel;I Schalk;L Ehret-Sabatier;F Bouet

  • Acetylcholinesterase: From 3D structure to function

    Hay Dvir;Israel Silman;Michal Harel;Terrone L. Rosenberry

  • Structure and Evolution of the Serum Paraoxonase Family of Detoxifying and Anti-Atherosclerotic Enzymes

    Michal Harel;Amir Aharoni;Leonid Gaidukov;Boris Brumshtein

  • Relationship between intrinsic connections and functional architecture revealed by optical imaging and in vivo targeted biocytin injections in primate striate cortex

    R Malach;Y Amir;M Harel;A Grinvald

  • Relationship between sequence conservation and three‐dimensional structure in a large family of esterases, lipases, and related proteins

    Miroslaw Cygler;Joseph D. Schrag;Joel L. Sussman;Michal Harel

  • Specific chemical and structural damage to proteins produced by synchrotron radiation.

    Martin Weik;Raimond B. G. Ravelli;Gitay Kryger;Sean McSweeney

  • Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.

    Mia L. Raves;Michal Harel;Yuan Ping Pang;Israel Silman

  • The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase.

    Michal Harel;Daniel M. Quinn;Haridasan K. Nair;Israel Silman

  • Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

    Gitay Kryger;Michal Harel;Kurt Giles;Lilly Toker

  • Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis.

    M Harel;J L Sussman;E Krejci;S Bon

  • Three‐dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors

    Michal Harel;Gitay Kryger;Terrone L. Rosenberry;William D. Mallender

  • Cortical hierarchy reflected in the organization of intrinsic connections in macaque monkey visual cortex

    Y. Amir;M. Harel;Rafael Malach

  • Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine

    P. Bar-On;C. B. Millard;M. Harel;H. Dvir

  • Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.

    Charles B. Millard;Gitay Kryger;Arie Ordentlich;Harry M. Greenblatt

  • X‐ray structure of human acid‐β‐glucosidase, the defective enzyme in Gaucher disease

    Hay Dvir;Michal Harel;Andrew A McCarthy;Lilly Toker

  • Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

    Michal Harel;Rona Ortenberg;Rona Ortenberg;Siva Karthik Varanasi;Kailash Chandra Mangalhara

  • Crystal structure of an acetylcholinesterase–fasciculin complex: interaction of a three-fingered toxin from snake venom with its target

    Michal Harel;Gerard J Kleywegt;Raimond Bg Ravelli;Israel Silman

  • Insights into protein adaptation to a saturated salt environment from the crystal structure of a halophilic 2Fe-2S ferredoxin

    Felix Frolow;Michal Harel;Joel L. Sussman;Moshe Mevarech

Frequent Co-Authors

Joel L. Sussman
Joel L. Sussman Weizmann Institute of Science
Israel Silman
Israel Silman Weizmann Institute of Science
Rafael Malach
Rafael Malach Weizmann Institute of Science
Ashesh D. Mehta
Ashesh D. Mehta Feinstein Institute for Medical Research
Tamar Geiger
Tamar Geiger Tel Aviv University
Itzhak Fried
Itzhak Fried University of California, Los Angeles
Charles E. Schroeder
Charles E. Schroeder Nathan Kline Institute for Psychiatric Research
Felix Frolow
Felix Frolow Tel Aviv University
Raimond B. G. Ravelli
Raimond B. G. Ravelli Maastricht University
Amos Arieli
Amos Arieli Weizmann Institute of Science

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