What is she best known for?
The fields of study she is best known for:
- Enzyme
- Organic chemistry
- Biochemistry
Her primary scientific interests are in Acetylcholinesterase, Enzyme inhibitor, Biochemistry, Structure–activity relationship and Stereochemistry.
Her Acetylcholinesterase research integrates issues from In vitro, Binding site and Amyloid precursor protein.
Manuela Bartolini has researched Enzyme inhibitor in several fields, including Mechanism of action and Circular dichroism.
Her work in Biochemistry addresses subjects such as Alzheimer's disease, which are connected to disciplines such as Neurodegeneration and Neuroscience.
Within one scientific family, Manuela Bartolini focuses on topics pertaining to Lead compound under Structure–activity relationship, and may sometimes address concerns connected to Anti alzheimer, Reactive oxygen species, Lipoic acid and Pharmacophore.
In general Stereochemistry, her work in Quantitative structure–activity relationship is often linked to Structure based linking many areas of study.
Her most cited work include:
- β-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies (410 citations)
- Insight Into the Kinetic of Amyloid β (1–42) Peptide Self‐Aggregation: Elucidation of Inhibitors’ Mechanism of Action (263 citations)
- 3-(4-{[Benzyl(methyl)amino]methyl}phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) Inhibits Both Acetylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation: A Dual Function Lead for Alzheimer's Disease Therapy§ (200 citations)
What are the main themes of her work throughout her whole career to date?
Manuela Bartolini mainly investigates Acetylcholinesterase, Pharmacology, Stereochemistry, Biochemistry and Tacrine.
Her Acetylcholinesterase research is multidisciplinary, incorporating elements of Structure–activity relationship, Enzyme inhibitor and Cholinesterase.
Her Pharmacology course of study focuses on Disease and Drug discovery and Neuroscience.
Manuela Bartolini combines subjects such as Lead compound, Binding site and Active site with her study of Stereochemistry.
Her Amyloid research extends to Biochemistry, which is thematically connected.
The Tacrine study combines topics in areas such as Pharmacophore and IC50.
She most often published in these fields:
- Acetylcholinesterase (37.61%)
- Pharmacology (24.31%)
- Stereochemistry (23.85%)
What were the highlights of her more recent work (between 2018-2021)?
- Pharmacology (24.31%)
- Acetylcholinesterase (37.61%)
- Tacrine (17.43%)
In recent papers she was focusing on the following fields of study:
Her scientific interests lie mostly in Pharmacology, Acetylcholinesterase, Tacrine, Butyrylcholinesterase and In vitro.
Her work deals with themes such as Disease, Catalase and Ligand, which intersect with Pharmacology.
Her Acetylcholinesterase research incorporates elements of Neurotoxicity and Toxicity.
Her study in Tacrine is interdisciplinary in nature, drawing from both Cholinergic, Agonist, IC50, Pharmacophore and Structure–activity relationship.
Her Butyrylcholinesterase study incorporates themes from Oxidative stress and Potency.
The various areas that Manuela Bartolini examines in her In vitro study include Anti alzheimer, Human serum albumin, Circular dichroism and Amyloid.
Between 2018 and 2021, her most popular works were:
- Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease. (32 citations)
- Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase. (25 citations)
- Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3. (14 citations)
In her most recent research, the most cited papers focused on:
- Enzyme
- Organic chemistry
- Gene
Manuela Bartolini focuses on Tacrine, Pharmacology, Acetylcholinesterase, Butyrylcholinesterase and Neuroprotection.
Her Tacrine study is related to the wider topic of Enzyme.
Her research in Pharmacology focuses on subjects like Ligand, which are connected to Cholinesterase.
Her Acetylcholinesterase study combines topics in areas such as Pharmacophore and Structure–activity relationship.
Manuela Bartolini has included themes like Stereochemistry, GSK-3, Cell growth and Cytotoxicity in her Structure–activity relationship study.
Her Neuroprotection research includes elements of Alzheimer's disease and Cannabinoid receptor, Cannabinoid receptor type 2.
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