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Manuela Bartolini

Manuela Bartolini

D-Index & Metrics

Chemistry

D-Index
61
Citations
11749
World Ranking
9354
National Ranking
273

Overview

Manuela Bartolini is affiliated with the University of Bologna in Italy and has a research focus spanning medicine, biochemistry, genetics, and molecular biology. The scientist's work intersects various subfields including pharmacology, molecular biology, computational theory and mathematics, complementary and alternative medicine, and physiology. Bartolini's research topics include cholinesterase and neurodegenerative diseases, computational drug discovery methods, medicinal plants and neuroprotection, Alzheimer's disease research and treatments, chemical synthesis and alkaloids, liver disease diagnosis and treatment, and DNA repair mechanisms.

Frequent coauthors in Bartolini's research include Marina Naldi, Daniele Tedesco, María Laura Bolognesi, Diego Muñoz-Torrero, and Ondřej Soukup.

The scientist has published extensively in several key journals:

  • Journal of Medicinal Chemistry (4 publications)
  • European Journal of Medicinal Chemistry (4 publications)
  • ACS Chemical Neuroscience (3 publications)
  • Molecules (3 publications)
  • Bioorganic Chemistry (2 publications)

Some of the notable recent papers include:

  • Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease, 2021, Journal of Medicinal Chemistry
  • Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice, 2020, Journal of Medicinal Chemistry
  • Determination of Effective Albumin in Patients With Decompensated Cirrhosis: Clinical and Prognostic Implications, 2021, Hepatology
  • Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease, 2022, Journal of Medicinal Chemistry
  • N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study, 2020, Bioorganic Chemistry

Best Publications

  • β-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies

    Manuela Bartolini;Carlo Bertucci;Vanni Cavrini;Vincenza Andrisano

  • Insight Into the Kinetic of Amyloid β (1–42) Peptide Self-Aggregation: Elucidation of Inhibitors’ Mechanism of Action

    Manuela Bartolini;Carlo Bertucci;Maria Laura Bolognesi;Andrea Cavalli

  • 3-(4-{[Benzyl(methyl)amino]methyl}phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) Inhibits Both Acetylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation: A Dual Function Lead for Alzheimer's Disease Therapy§

    Lorna Piazzi;Angela Rampa;Alessandra Bisi;Silvia Gobbi

  • Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.

    Maria Laura Bolognesi;Andrea Cavalli;Luca Valgimigli;Manuela Bartolini

  • Rational approach to discover multipotent anti-Alzheimer drugs.

    Michela Rosini;Vincenza Andrisano;Manuela Bartolini;Maria L. Bolognesi

  • Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds.

    Lorna Piazzi;Andrea Cavalli;Francesco Colizzi;Federica Belluti

  • Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.

    Pilar Munoz-Ruiz;Laura Rubio;Esther Garcia-Palomero;Isabel Dorronsoro

  • Novel Donepezil-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation

    Pelayo Camps;Xavier Formosa;Carles Galdeano;Tània Gómez

  • Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.

    Michela Rosini;Elena Simoni;Manuela Bartolini;Andrea Cavalli

  • Pyrano[3,2-c]quinoline−6-Chlorotacrine Hybrids as a Novel Family of Acetylcholinesterase- and β-Amyloid-Directed Anti-Alzheimer Compounds

    Pelayo Camps;Xavier Formosa;Carles Galdeano;Diego Muñoz-Torrero

  • A small molecule targeting the multifactorial nature of Alzheimer's disease.

    Andrea Cavalli;Maria Laura Bolognesi;Simona Capsoni;Vincenza Andrisano

  • Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, β Amyloid Aggregation, and Aβ Neurotoxicity

    Stefano Rizzo;Céline Rivière;Lorna Piazzi;Alessandra Bisi

  • SAR of 9-Amino-1,2,3,4-tetrahydroacridine-Based Acetylcholinesterase Inhibitors: Synthesis, Enzyme Inhibitory Activity, QSAR, and Structure-Based CoMFA of Tacrine Analogues

    Maurizio Recanatini;Andrea Cavalli;Federica Belluti;Lorna Piazzi

  • Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.

    José Marco-Contelles;Rafael León;Cristóbal de los Ríos;Abdelouahid Samadi

  • Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects

    Eugenie Nepovimova;Elisa Uliassi;Jan Korabecny;Luis Emiliano Peña-Altamira

  • Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease

    Maria Laura Bolognesi;Rita Banzi;Manuela Bartolini;Andrea Cavalli

  • Strategies for the Inhibition of Protein Aggregation in Human Diseases

    Manuela Bartolini;Vincenza Andrisano

  • Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues.

    Maria Laura Bolognesi;Manuela Bartolini;Andrea Cavalli;Vincenza Andrisano

  • Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.

    Xiaoming Zha;Doriano Lamba;Lili Zhang;Yinghan Lou

  • Propidium-Based Polyamine Ligands as Potent Inhibitors of Acetylcholinesterase and Acetylcholinesterase-Induced Amyloid-β Aggregation

    Maria Laura Bolognesi;Vincenza Andrisano;Manuela Bartolini;Rita Banzi

Frequent Co-Authors

Vincenza Andrisano
Vincenza Andrisano University of Bologna
Maria Laura Bolognesi
Maria Laura Bolognesi University of Bologna
Andrea Cavalli
Andrea Cavalli Italian Institute of Technology
Maurizio Recanatini
Maurizio Recanatini University of Bologna
Vanni Cavrini
Vanni Cavrini University of Bologna
José Marco-Contelles
José Marco-Contelles Spanish National Research Council
F. Javier Luque
F. Javier Luque University of Barcelona
Patrizia Hrelia
Patrizia Hrelia University of Bologna
Romana Fato
Romana Fato University of Bologna
Nibaldo C. Inestrosa
Nibaldo C. Inestrosa Pontificia Universidad Católica de Chile

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