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Chemistry

D-Index
60
Citations
12835
World Ranking
9695
National Ranking
323

Overview

José Marco-Contelles is affiliated with the Spanish National Research Council in Spain. Their research primarily spans the fields of chemistry, medicine, and biochemistry, genetics, and molecular biology. Within these areas, their subfields of focus include organic chemistry, pharmacology, molecular biology, computational theory and mathematics, and biophysics.

The scientist's research topics cover a diverse range of subjects, with particular emphasis on cholinesterase and neurodegenerative diseases, computational drug discovery methods, electron spin resonance studies, synthesis and biological activity, free radicals and antioxidants, nitric oxide and endothelin effects, and click chemistry and its applications.

José Marco-Contelles has contributed frequently to several scientific journals. The most common publication venues include:

  • International Journal of Molecular Sciences
  • Molecules
  • Antioxidants
  • ChemistrySelect
  • Journal of Medicinal Chemistry

Among recent papers authored or co-authored by José Marco-Contelles are:

  • "Efficacy of Acetylcholinesterase Inhibitors on Cognitive Function in Alzheimer's Disease. Review of Reviews," 2021, Biomedicines
  • "Recent Advances on Nitrones Design for Stroke Treatment," 2020, Journal of Medicinal Chemistry
  • "2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease," 2020, European Journal of Medicinal Chemistry
  • "From Seeds of Apium graveolens Linn. to a Cerebral Ischemia Medicine: The Long Journey of 3-n-Butylphthalide," 2020, Journal of Medicinal Chemistry
  • "(±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease," 2021, ACS Chemical Neuroscience

The scientist collaborates with a number of frequent co-authors, including:

  • Isabel Iriepa
  • Lhassane Ismaïli
  • Mourad Chioua
  • Francisco López-Muñoz
  • Fakher Chabchoub

Best Publications

  • Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease

    Rafael León;Antonio G. Garcia;José Marco-Contelles

  • Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease

    Irene Bolea;Jordi Juárez-Jiménez;Cristóbal de los Rı́os;Mourad Chioua

  • The multifactorial nature of Alzheimer's disease for developing potential therapeutics.

    M. Carmo Carreiras;Eduardo Mendes;M. Jesús Perry;Ana Paula Francisco

  • Recent Developments in the Metal‐Catalyzed Reactions of Metallocarbenoids from Propargylic Esters

    Unknown

  • The effect of a hydroxy protecting group on the PtCl2-catalyzed cyclization of dienynes--a novel, efficient, and selective synthesis of carbocycles.

    Emily Mainetti;Virginie Mouriès;Louis Fensterbank;Max Malacria

  • Mechanisms of the transition metal-mediated hydroarylation of alkynes and allenes

    Elena Soriano;José Marco-Contelles

  • Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease.

    Lhassane Ismaili;Bernard Refouvelet;Mohamed Benchekroun;Simone Brogi

  • Mechanistic Insights on the Cycloisomerization of Polyunsaturated Precursors Catalyzed by Platinum and Gold Complexes

    Unknown

  • Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease.

    Alejandro Romero;Ramón Cacabelos;María J. Oset-Gasque;Abdelouahid Samadi

  • Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.

    José Marco-Contelles;Rafael León;Cristóbal de los Ríos;Abdelouahid Samadi

  • Alzheimer's Disease, the "One-Molecule, One-Target" Paradigm, and the Multitarget Directed Ligand Approach.

    María Jesús Oset-Gasque;José Marco-Contelles

  • Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

    Oscar M. Bautista-Aguilera;Gerard Esteban;Irene Bolea;Katarina Nikolic

  • Multi-target directed donepezil-like ligands for Alzheimer's disease

    Mercedes Unzeta;Gerard Esteban;Irene Bolea;Wieslawa Agnieszka Fogel

  • Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.

    Li Wang;Gerard Esteban;Masaki Ojima;Oscar M Bautista-Aguilera

  • PtCl2-Catalyzed Cycloisomerizations of Allenynes

    Nicolas Cadran;Kevin Cariou;Gwénaëlle Hervé;Corinne Aubert

  • The Antioxidant Additive Approach for Alzheimer’s Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

    Mohamed Benchekroun;Alejandro Romero;Javier Egea;Rafael León

  • Synthesis of Enantiomerically Pure, Highly Functionalized, Medium-Sized Carbocycles from Carbohydrates: Formal Total Synthesis of (+)-Calystegine B<sub>2</sub>

    Unknown

  • Theoretical analysis of the high versatility in PtCl2-mediated cycloisomerization of enynes on a common mechanistic basis.

    Elena Soriano;José Marco-Contelles

  • Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors.

    Mourad Chioua;Abdelouahid Samadi;Elena Soriano;Olivier Lozach

  • Ischemic brain injury: New insights on the protective role of melatonin

    Eva Ramos;Paloma Patiño;Russel J. Reiter;Emilio Gil-Martín

  • An update on the pharmacology of galantamine

    Mercedes Villarroya;Antonio G García;José Marco-Contelles;Manuela G López

  • Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.

    Emna Maalej;Fakher Chabchoub;María Jesús Oset-Gasque;Mario Esquivias-Pérez

  • New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.

    Rafael León;Cristóbal de los Ríos;Cristóbal de los Ríos;José Marco-Contelles;Oscar Huertas

Frequent Co-Authors

Dimitra Hadjipavlou-Litina
Dimitra Hadjipavlou-Litina Aristotle University of Thessaloniki
Rona R. Ramsay
Rona R. Ramsay University of St Andrews
Manuela Bartolini
Manuela Bartolini University of Bologna
Benito Alcaide
Benito Alcaide Complutense University of Madrid
Vincenza Andrisano
Vincenza Andrisano University of Bologna
Pedro Almendros
Pedro Almendros Spanish National Research Council
Louis Fensterbank
Louis Fensterbank Sorbonne University
Max Malacria
Max Malacria Sorbonne University
Jan Balzarini
Jan Balzarini KU Leuven
Christophe Len
Christophe Len PSL University

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