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Jan Balzarini

Jan Balzarini

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Biology and Biochemistry
Belgium
2026
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Chemistry
Belgium
2026

D-Index & Metrics

Chemistry

D-Index
129
Citations
72342
World Ranking
342
National Ranking
5

Biology and Biochemistry

D-Index
133
Citations
76433
World Ranking
370
National Ranking
6

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Belgium Leader Award
  • 2026 - Research.com Chemistry in Belgium Leader Award
  • 2025 - Research.com Biology and Biochemistry in Belgium Leader Award
  • 2025 - Research.com Chemistry in Belgium Leader Award
  • 2023 - Research.com Microbiology in Belgium Leader Award
  • 2022 - Research.com Chemistry in Belgium Leader Award
  • 2022 - Research.com Microbiology in Belgium Leader Award
  • 2003 - Member of the European Academy of Sciences

Overview

Jan Balzarini is affiliated with KU Leuven in Belgium and has made contributions primarily in the field of Chemistry, with a focus on Organic Chemistry. Their work also spans subfields such as Food Science and Pharmacology. The scientist's research emphasizes synthesis and biological activity, including synthesis and biological evaluation, the characterization of heterocyclic compounds, essential oils with antimicrobial activity, and studies related to cholinesterase and neurodegenerative diseases.

Frequent coauthors in their research include Sandra Liekens, Stefano Manfredini, Romeo Romagnoli, Filippo Prencipe, and Paola Oliva. This indicates a collaborative research environment across multiple projects, with specific recurring partnerships.

Jan Balzarini has contributed papers published in several notable scientific journals. These include:

  • Benzothiazole Derivatives as Multifunctional Antioxidant Agents for Skin Damage: Structure-Activity Relationship of a Scaffold Bearing a Five-Membered Ring System (2022, Antioxidants)
  • Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization (2020, Bioorganic Chemistry)
  • Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3',4',5'-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold (2020, Molecules)

The scientist's publications have appeared primarily in the journals Antioxidants, Bioorganic Chemistry, and Molecules.

The main research topics covered by Jan Balzarini include:

  • Synthesis and biological activity
  • Synthesis and Biological Evaluation
  • Synthesis and Characterization of Heterocyclic Compounds
  • Essential Oils and Antimicrobial Activity
  • Cholinesterase and Neurodegenerative Diseases

Jan Balzarini was recognized as a Member of the European Academy of Sciences in 2003. This membership indicates professional acknowledgement within the scientific community.

Best Publications

  • Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

    Rudi Pauwels;Jan Balzarini;Masanori Baba;Robert Snoeck

  • A novel selective broad-spectrum anti-DNA virus agent.

    Erik De Clercq;Antonin Holý;Ivan Rosenberg;Takashi Sakuma

  • 1,2,3-Triazole-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D- ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"-oxathiole 2",2"-dioxide) (TSAO) analogues: synthesis and anti-HIV-1 activity.

    Rosa Alvarez;Sonsoles Velázquez;Ana San-Félix;Stefano Aquaro

  • Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines.

    Erik De Clercq;Takashi Sakuma;Masanori Baba;Rudi Pauwels

  • Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro.

    M Baba;R Pauwels;J Balzarini;J Arnout

  • Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

    J Wijnholds;C A Mol;L van Deemter;M de Haas

  • A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.

    Tadashi Miyasaka;Hiromichi Tanaka;Masanori Baba;Hiroyuki Hayakawa

  • Early restaging positron emission tomography with 18F-fluorodeoxyglucose predicts outcome in patients with aggressive non-Hodgkin’s lymphoma

    K. Spaepen;S. Stroobants;P. Dupont;P. Vandenberghe

  • Prognostic value of positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose ([18f]FDG) after first-line chemotherapy in non-Hodgkin's lymphoma : Is [18F]FDG-PET a valid alternative to conventional diagnostic methods?

    Karoline Spaepen;Sigrid Stroobants;Patrick Dupont;Steven Van Steenweghen

  • Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds.

    J Balzarini;P Herdewijn;E De Clercq

  • Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine.

    J Balzarini;A Holy;J Jindrich;L Naesens

  • 3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.

    P Herdewijn;J Balzarini;E De Clercq;R Pauwels

  • Synthesis and antiviral activity of new pyrazole and thiazole derivatives

    Osama I. El-Sabbagh;Mohamed M. Baraka;Samy M. Ibrahim;Christophe Pannecouque

  • Characterization of the Transport of Nucleoside Analog Drugs by the Human Multidrug Resistance Proteins MRP4 and MRP5

    Glen Reid;Peter Wielinga;Noam Zelcer;Marcel de Haas

  • Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.

    M. Baba;H. Tanaka;E. De Clercq;R. Pauwels

  • Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100.

    E De Clercq;N Yamamoto;R Pauwels;J Balzarini

  • Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy.

    Jan Balzarini

  • The ProTide Prodrug Technology: From the Concept to the Clinic

    Youcef Mehellou;Hardeep S. Rattan;Jan Balzarini

  • Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents.

    R Pauwels;J Balzarini;D Schols;M Baba

  • Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite

    Christopher McGuigan;Dominique Cahard;Hendrika M. Sheeka;Erik De Clercq

  • The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: a comparison with their parental 2',3'-dideoxyribonucleosides.

    J Balzarini;G J Kang;M Dalal;P Herdewijn

Frequent Co-Authors

Erik De Clercq
Erik De Clercq Rega Institute for Medical Research
Robert Snoeck
Robert Snoeck KU Leuven
Christophe Pannecouque
Christophe Pannecouque Rega Institute for Medical Research
Lieve Naesens
Lieve Naesens Rega Institute for Medical Research
Johan Neyts
Johan Neyts Rega Institute for Medical Research
Antonín Holý
Antonín Holý Czech Academy of Sciences

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