D-Index & Metrics Best Publications
Microbiology
Belgium
2023
Chemistry
Belgium
2023

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 109 Citations 51,252 1,408 World Ranking 454 National Ranking 6
Microbiology D-index 116 Citations 53,492 1,273 World Ranking 82 National Ranking 3

Research.com Recognitions

Awards & Achievements

2023 - Research.com Chemistry in Belgium Leader Award

2023 - Research.com Microbiology in Belgium Leader Award

2022 - Research.com Microbiology in Belgium Leader Award

2003 - Member of the European Academy of Sciences

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Organic chemistry
  • Gene

Jan Balzarini focuses on Stereochemistry, Virology, Virus, Biochemistry and In vitro. His biological study spans a wide range of topics, including Biological activity, Structure–activity relationship, Chemical synthesis and Cytotoxicity. His research links Cell culture with Virology.

His work carried out in the field of Virus brings together such families of science as Reverse transcriptase, Microbiology and Mechanism of action. His research investigates the link between Biochemistry and topics such as Molecular biology that cross with problems in Kinase. The various areas that he examines in his In vitro study include RNA, DNA, In vivo and Pharmacology.

His most cited work include:

  • Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds (1426 citations)
  • A novel selective broad-spectrum anti-DNA virus agent. (667 citations)
  • Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines (436 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Stereochemistry, Biochemistry, Virology, Nucleoside and Virus. His Stereochemistry study combines topics in areas such as Biological activity, In vitro, Structure–activity relationship and Chemical synthesis. His Structure–activity relationship research integrates issues from Moiety and Cytotoxicity.

His Biochemistry study frequently draws connections between adjacent fields such as Molecular biology. His Virology research is multidisciplinary, incorporating elements of Cell culture, Reverse transcriptase and Mutant. His Nucleoside research includes themes of Prodrug and Thymidine kinase.

He most often published in these fields:

  • Stereochemistry (47.57%)
  • Biochemistry (22.64%)
  • Virology (22.04%)

What were the highlights of his more recent work (between 2011-2021)?

  • Stereochemistry (47.57%)
  • Biochemistry (22.64%)
  • Nucleoside (18.98%)

In recent papers he was focusing on the following fields of study:

His main research concerns Stereochemistry, Biochemistry, Nucleoside, Prodrug and Structure–activity relationship. His work deals with themes such as Cell culture, In vitro, Reverse transcriptase and DNA, which intersect with Stereochemistry. Biochemistry is often connected to Molecular biology in his work.

His Nucleoside research includes elements of Nucleobase, Nucleotide, Deoxyuridine and Enzyme. His Prodrug study integrates concerns from other disciplines, such as Protide, Nucleoside triphosphate, Phosphoramidate, Biological activity and Dipeptidyl peptidase. His Structure–activity relationship research is multidisciplinary, relying on both Apoptosis, Tubulin, Cell growth and Cytotoxicity.

Between 2011 and 2021, his most popular works were:

  • Application of ProTide Technology to Gemcitabine: A Successful Approach to Overcome the Key Cancer Resistance Mechanisms Leads to a New Agent (NUC-1031) in Clinical Development (120 citations)
  • Vaginal microbiota and its role in HIV transmission and infection (92 citations)
  • The lantibiotic peptide labyrinthopeptin A1 demonstrates broad anti-HIV and anti-HSV activity with potential for microbicidal applications. (82 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Organic chemistry
  • Gene

Jan Balzarini mainly investigates Stereochemistry, Biochemistry, Structure–activity relationship, In vitro and DNA. Jan Balzarini combines subjects such as Molecule, Prodrug and Reverse transcriptase with his study of Stereochemistry. The study incorporates disciplines such as Molecular biology and Virus in addition to Biochemistry.

His Virus study is associated with Virology. His research integrates issues of Cell culture, Viral replication, Cell growth, Apoptosis and Cytotoxicity in his study of Structure–activity relationship. His studies deal with areas such as Nucleobase, Thymidine and Uridine as well as Nucleoside.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

Rudi Pauwels;Jan Balzarini;Masanori Baba;Robert Snoeck.
Journal of Virological Methods (1988)

2508 Citations

A novel selective broad-spectrum anti-DNA virus agent.

Erik De Clercq;Antonin Holý;Ivan Rosenberg;Takashi Sakuma.
Nature (1986)

1086 Citations

Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines.

Erik De Clercq;Takashi Sakuma;Masanori Baba;Rudi Pauwels.
Antiviral Research (1987)

701 Citations

Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro.

M Baba;R Pauwels;J Balzarini;J Arnout.
Proceedings of the National Academy of Sciences of the United States of America (1988)

678 Citations

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

J Wijnholds;C A Mol;L van Deemter;M de Haas.
Proceedings of the National Academy of Sciences of the United States of America (2000)

577 Citations

A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.

Tadashi Miyasaka;Hiromichi Tanaka;Masanori Baba;Hiroyuki Hayakawa.
Journal of Medicinal Chemistry (1989)

537 Citations

Early restaging positron emission tomography with 18F-fluorodeoxyglucose predicts outcome in patients with aggressive non-Hodgkin’s lymphoma

K. Spaepen;S. Stroobants;P. Dupont;P. Vandenberghe.
Annals of Oncology (2002)

513 Citations

Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds.

J Balzarini;P Herdewijn;E De Clercq.
Journal of Biological Chemistry (1989)

490 Citations

3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.

P Herdewijn;J Balzarini;E De Clercq;R Pauwels.
Journal of Medicinal Chemistry (1987)

473 Citations

Characterization of the Transport of Nucleoside Analog Drugs by the Human Multidrug Resistance Proteins MRP4 and MRP5

Glen Reid;Peter Wielinga;Noam Zelcer;Marcel de Haas.
Molecular Pharmacology (2003)

438 Citations

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