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Microbiology

D-Index
64
Citations
14367
World Ranking
2616
National Ranking
61

Overview

Lieve Naesens is affiliated with the Rega Institute for Medical Research in Belgium. Their research primarily spans the field of Medicine, with a focus on multiple interconnected subfields such as Epidemiology, Infectious Diseases, Organic Chemistry, Molecular Biology, and Immunology. This multidisciplinary approach informs their investigations into viral infections and therapeutic interventions.

The scientist's publication record includes numerous papers across several high-impact venues. They have contributed to bioRxiv (Cold Spring Harbor Laboratory) with 12 published works, The Cambridge Structural Database with 6, Journal of Medicinal Chemistry and Antiviral Research each with 5, and Bioorganic Chemistry with 5 publications. Their frequent coauthors include Annelies Stevaert, Ria Van Berwaer, Julie Vandeput, Steven De Jonghe, and Benjamin Van Loy.

Naesens's research topics cover a range of virological and immunological studies:

  • Influenza Virus Research Studies
  • SARS-CoV-2 and COVID-19 Research
  • Respiratory viral infections research
  • Viral gastroenteritis research and epidemiology
  • Interferon and immune responses
  • Antimicrobial Peptides and Activities
  • RNA and protein synthesis mechanisms

Selected recent papers illustrate the scope of their work:

  • The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways, 2021, PLoS Pathogens
  • Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses, 2020, Molecules
  • Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease, 2021, Journal of Medicinal Chemistry
  • Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model, 2021, Virulence
  • Reprogramming of the Antibacterial Drug Vancomycin Results in Potent Antiviral Agents Devoid of Antibacterial Activity, 2020, Pharmaceuticals

Best Publications

  • Update on Human Herpesvirus 6 Biology, Clinical Features, and Therapy

    Leen De Bolle;Lieve Naesens;Erik De Clercq

  • Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine.

    J Balzarini;A Holy;J Jindrich;L Naesens

  • Treatment of Severe Laryngeal Papillomatosis With Intralesional Injections of Cidofovir ((S)-1-(3-Hydroxy-2-Phosphonylmethoxypropyl) Cytosine)

    Robert Snoeck;Willy Wellens;Christian Desloovere;Mark Van Ranst

  • Clinical features and treatment of adenovirus infections.

    Liesbeth Lenaerts;Erik De Clercq;Lieve Naesens

  • Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14.

    Festo Damian;Norbert Blaton;Lieve Naesens;Jan Balzarini

  • HPMPC (cidofovir), PMEA (adefovir) and related acyclic nucleoside phosphonate analogues: a review of their pharmacology and clinical potential in the treatment of viral infections

    L Naesens;R Snoeck;G Andrei;J Balzarini

  • 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys.

    Balzarini J;Naesens L;Slachmuylders J;Niphuis H

  • Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.

    J Balzarini;L Naesens;P Herdewijn;I Rosenberg

  • Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection

    Koert J Stittelaar;Johan Neyts;Lieve Naesens;Geert van Amerongen

  • Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8

    Erik De Clercq;Lieve Naesens;Leen De Bolle;Dominique Schols

  • Adjuvant Low‐Dose Cidofovir Therapy for BK Polyomavirus Interstitial Nephritis in Renal Transplant Recipients

    Dirk R.J. Kuypers;Ann-Karolien Vandooren;Evelyne Lerut;Pieter Evenepoel

  • Antiadenovirus Activities of Several Classes of Nucleoside and Nucleotide Analogues

    Lieve Naesens;Liesbeth Lenaerts;Graciela Andrei;Robert Snoeck

  • Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives.

    J. Balzarini;A. Karlsson;S. Aquaro;C. F. Perno

  • 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.

    Antonín Holý;Ivan Votruba;Milena Masojídková;Graciela Andrei

  • The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design

    Annelies Stevaert;Lieve Naesens

  • Novel Inhibitors of Influenza Virus Fusion: Structure-Activity Relationship and Interaction with the Viral Hemagglutinin

    Evelien Vanderlinden;Fusun Göktaş;Zafer Cesur;Matheus Froeyen

  • Characterization of the Activation Pathway of Phosphoramidate Triester Prodrugs of Stavudine and Zidovudine

    D Saboulard;L Naesens;D Cahard;A Salgado

  • Recent developments in herpesvirus therapy.

    Naesens L;De Clercq E

  • Antiretroviral Efficacy and Pharmacokinetics of Oral Bis(isopropyloxycarbonyloxymethyl)9-(2-Phosphonylmethoxypropyl)adenine in Mice

    Lieve Naesens;Norbert Bischofberger;Patrick Augustijns;Pieter Annaert

  • Role of MRP4 and MRP5 in biology and chemotherapy.

    Janardhan Sampath;Masashi Adachi;Sigrid Hatse;Lieve Naesens

  • Heterocyclic rimantadine analogues with antiviral activity

    George Stamatiou;George B. Foscolos;George Fytas;Antonios Kolocouris

Frequent Co-Authors

Jan Balzarini
Jan Balzarini KU Leuven
Erik De Clercq
Erik De Clercq Rega Institute for Medical Research
Robert Snoeck
Robert Snoeck KU Leuven
Johan Neyts
Johan Neyts Rega Institute for Medical Research
Luke W. Guddat
Luke W. Guddat University of Queensland
Antonín Holý
Antonín Holý Czech Academy of Sciences
Christophe Pannecouque
Christophe Pannecouque Rega Institute for Medical Research

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