World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
12922
World Ranking
7578
National Ranking
3443

Research.com Recognitions

  • 1980 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Karl Y. Hostetler is affiliated with the University of California, San Diego in the United States. Their research primarily focuses on medicine, with a particular emphasis on infectious diseases, epidemiology, oncology, cardiology and cardiovascular medicine, and genetics.

The scientist's work covers a range of topics including COVID-19 clinical research studies, SARS-CoV-2 and COVID-19 research, respiratory viral infections research, PARP inhibition in cancer therapy, viral infections and immunology research, virus-based gene therapy research, and cytomegalovirus and herpesvirus research.

Recent papers authored or coauthored by Karl Y. Hostetler include:

  • Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs (2021, Antimicrobial Agents and Chemotherapy)
  • Broad-Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available, Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside (GS-441524) (2021, Microbiology Spectrum)
  • Rethinking Remdesivir: Synthesis, Antiviral Activity and Pharmacokinetics of Oral Lipid Prodrugs (2020, bioRxiv (Cold Spring Harbor Laboratory))
  • 1-O-Octadecyl-2-O-benzyl-sn-glyceryl-3-phospho-GS-441524 (V2043). Evaluation of Oral V2043 in a Mouse Model of SARS-CoV-2 Infection and Synthesis and Antiviral Evaluation of Additional Phospholipid Esters with Enhanced Anti-SARS-CoV-2 Activity (2023, Journal of Medicinal Chemistry)
  • Enhanced broad spectrum in vitro antiviral efficacy of 3-F-4-MeO-Bn, 3-CN, and 4-CN derivatives of lipid remdesivir nucleoside monophosphate prodrugs (2023, Antiviral Research)

Frequent coauthors of Karl Y. Hostetler include:

  • Robert T. Schooley
  • James R. Beadle
  • Nadejda Valiaeva
  • Joyce Murphy
  • Aaron F. Carlin

The scientist's research has been predominantly published in these venues:

  • Antimicrobial Agents and Chemotherapy
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Microbiology Spectrum
  • Journal of Medicinal Chemistry
  • Antiviral Research

Karl Y. Hostetler was recognized as a Fellow of the John Simon Guggenheim Memorial Foundation in 1980.

Best Publications

  • An improved two dimensional thin-layer chromatography system for the separation of phosphatidylglycerol and its derivatives

    B. J. H. M. Poorthuis;B. J. H. M. Poorthuis;Paul J. Yazaki;Paul J. Yazaki;Karl Y. Hostetler;Karl Y. Hostetler

  • Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: current state of the art

    Karl Y. Hostetler

  • LIPID DERIVATIVES OF ANTIVIRAL NUCLEOSIDE ANALOGUES, LIPOSOMES THEREOF AND PHARMACEUTICAL USE

    Hostetler Karl Y;Raj Kumar;Stuhmiller Louise M

  • Synthesis and antiretroviral activity of phospholipid analogs of azidothymidine and other antiviral nucleosides.

    K. Y. Hostetler;L. M. Stuhmiller;H. B. M. Lenting;H. Van Den Bosch

  • Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir.

    Earl R. Kern;Caroll Hartline;Emma Harden;Kathy Keith

  • Lipid derivatives of phosphonoacids for liposomal incorporation and method of use

    Karl Y. Hostetler;Raj Kumar

  • Alkoxyalkyl Esters of Cidofovir and Cyclic Cidofovir Exhibit Multiple-Log Enhancement of Antiviral Activity against Cytomegalovirus and Herpesvirus Replication In Vitro

    James R. Beadle;Caroll Hartline;Kathy A. Aldern;Natalie Rodriguez

  • Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney

    Stephanie L Ciesla;Julissa Trahan;W.Brad Wan;James R Beadle

  • Mitochondrial cardiolipin in diverse eukaryotes. Comparison of biosynthetic reactions and molecular acyl species.

    Michael Schlame;Stuart Brody;Karl Y. Hostetler

  • Inhibition of lysosomal phospholipase A and phospholipase C by chloroquine and 4,4'-bis(diethylaminoethoxy) alpha, beta-diethyldiphenylethane.

    Y Matsuzawa;K Y Hostetler

  • Oral Treatment of Cowpox and Vaccinia Virus Infections in Mice with Ether Lipid Esters of Cidofovir

    Debra C. Quenelle;Deborah J. Collins;W. Brad Wan;James R. Beadle

  • Lipid derivatives of antiviral nucleosides, liposomal incorporation and method of use.

    Karl Y. Hostetler;Raj Kumar;Louise M. Stuhmiller

  • Ether Lipid-Ester Prodrugs of Acyclic Nucleoside Phosphonates: Activity against Adenovirus Replication In Vitro

    Caroll B. Hartline;Kortney M. Gustin;William B. Wan;Stephanie L. Ciesla

  • Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model

    R.Mark Buller;Gelita Owens;Jill Schriewer;Lora Melman

  • Increased Antiviral Activity of 1-O-Hexadecyloxypropyl-[2-14C]cidofovir in MRC-5 Human Lung Fibroblasts Is Explained by Unique Cellular Uptake and Metabolism

    Kathy A. Aldern;Stephanie L. Ciesla;Kristine L. Winegarden;Karl Y. Hostetler

  • Mechanism of Inhibition of Vaccinia Virus DNA Polymerase by Cidofovir Diphosphate

    Wendy C. Magee;Karl Y. Hostetler;David H. Evans

  • Properties of phospholipase C isolated from rat liver lysosomes.

    Y Matsuzawa;K Y Hostetler

  • Biosynthesis of cardiolipin in liver mitochondria.

    Karl Y. Hostetler;H. van Den Bosch;L.L.M. van Deenen

  • SUBCELLULAR AND SUBMITOCHONDRIAL LOCALIZATION OF THE BIOSYNTHESIS OF CARDIOLIPIN AND RELATED PHOSPHOLIPIDS IN RAT LIVER

    K.Y. Hostetler;H.Van Den Bosch

  • Comparative Activities of Lipid Esters of Cidofovir and Cyclic Cidofovir against Replication of Herpesviruses In Vitro

    Stephanie L. Williams-Aziz;Caroll B. Hartline;Emma A. Harden;Shannon L. Daily

Frequent Co-Authors

William R. Freeman
William R. Freeman University of California, San Diego
Douglas D. Richman
Douglas D. Richman University of California, San Diego
Earl R. Kern
Earl R. Kern University of Alabama
H. van den Bosch
H. van den Bosch Utrecht University
Brent E. Korba
Brent E. Korba Georgetown University
Robert T. Schooley
Robert T. Schooley University of California, San Diego
Bernard R. Landau
Bernard R. Landau Case Western Reserve University
Erik De Clercq
Erik De Clercq Rega Institute for Medical Research
Yuji Matsuzawa
Yuji Matsuzawa Sumitomo Hospital
John W. Mellors
John W. Mellors University of Pittsburgh

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring a career in Biology or Biochemistry opens doors to various online degree programs and flexible career paths. Fields related to life sciences offer both specialized and interdisciplinary opportunities for advancement.

For those interested in nutrition and health, online dietetics programs provide a cost-effective way to gain the credentials needed for roles like registered dietitian or nutritionist.

Professionals with a nursing background can broaden their qualifications through online rn to bsn programs, helping them move into supervisory or specialist nursing roles quickly.

If you're seeking leadership in healthcare, consider a masters degree in healthcare management. These programs equip graduates to oversee teams, manage clinical operations, and implement healthcare policies.

Finally, for those interested in mental health, the fastest pmhnp program offers a path to becoming a psychiatric mental health nurse practitioner, a fast-growing specialty.

Whether your goal is direct patient care, management, or a specialized field, online degrees make it easier to balance education with existing commitments.

Best Scientists Citing Karl Y. Hostetler

Trending Scientists

Recently Published Articles