Antonín Holý

Overview

Best Publications

• Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine.

  J Balzarini;A Holy;J Jindrich;L Naesens

  497
  Citations

• Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents.

  R Pauwels;J Balzarini;D Schols;M Baba

  367
  Citations

• (S)-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity.

  Erik De Clercq;Johan Descamps;Pierre De Somer;Antonín Holý

  365
  Citations

• (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication.

  R Snoeck;T Sakuma;E De Clercq;I Rosenberg

  323
  Citations

• Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids.

  Michal Hocek;Antonín Holý;and Ivan Votruba;Hana Dvořáková

  292
  Citations

• Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.

  J Balzarini;L Naesens;P Herdewijn;I Rosenberg

  286
  Citations

• Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base

  Antonín Holý;Jaroslav Günter;Hana Dvořáková;Milena Masojídková

  256
  Citations

• Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro.

  A. Holý;I. Votruba;A. Merta;J. Černý

  218
  Citations

• Synthesis of 9-(2-Phosphinomethoxyethyl)adenine and Related Compounds

  Petr Alexander;Antonín Holý;Milena Masojídková

  206
  Citations

• Antiadenovirus Activities of Several Classes of Nucleoside and Nucleotide Analogues

  Lieve Naesens;Liesbeth Lenaerts;Graciela Andrei;Robert Snoeck

  188
  Citations

• 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.

  Antonín Holý;Ivan Votruba;Milena Masojídková;Graciela Andrei

  185
  Citations

• Intracellular phosphorylation of broad-spectrum anti-DNA virus agent (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and inhibition of viral DNA synthesis.

  I Votruba;R Bernaerts;T Sakuma;E De Clercq

  165
  Citations

• 5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines: acyclic nucleoside phosphonate analogues with antiviral activity

  Dana Hocková;Antonín Holý;Milena Masojídková;Graciela Andrei

  156
  Citations

• Different inhibitory potencies of acyclic phosphonomethoxyalkyl nucleotide analogs toward DNA polymerases alpha, delta and epsilon.

  P Kramata;I Votruba;B Otová;A Holý

  154
  Citations

• Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics

  Dianne T Keough;Dana Hocková;Antonín Holý;Lieve M J Naesens

  148
  Citations

• Cytostatic 6-Arylpurine Nucleosides III. Synthesis and Structure-Activity Relationship Study in Cytostatic Activity of 6-Aryl-, 6-Hetaryl- and 6-Benzylpurine Ribonucleosides

  Michal Hocek;Antonín Holý;Ivan Votruba;Hana Dvořáková

  146
  Citations

• Activity of the (R)-Enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems

  J. Balzarini;S. Aquaro;C.-F. Perno;M. Witvrouw

  139
  Citations

• Nucleic acid components and their analogues. CLIII. Preparation of 2'-deoxy-L-ribonucleosides of the pyrimidine series

  A. Holý

  136
  Citations

• Antivaccinia Activities of Acyclic Nucleoside Phosphonate Derivatives in Epithelial Cells and Organotypic Cultures

  R. Snoeck;A. Holy;C. Dewolf-Peeters;J. Van Den Oord

  135
  Citations

• 9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo.

  J Balzarini;A Holy;J Jindrich;H Dvorakova

  133
  Citations