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Chemistry

D-Index
88
Citations
26919
World Ranking
2295
National Ranking
51

Overview

Helmut Sigel is affiliated with the University of Basel in Switzerland and has contributed to the fields of Medicine as well as Biochemistry, Genetics and Molecular Biology. Their work spans various subfields including Molecular Biology, Epidemiology, Radiology, Nuclear Medicine and Imaging, Cardiology and Cardiovascular Medicine, and General Health Professions.

The research topics addressed by Helmut Sigel involve:

  • Cytomegalovirus and herpesvirus research
  • RNA regulation and disease
  • Advanced MRI Techniques and Applications
  • Biochemical and Molecular Research
  • Viral Infections and Immunology Research
  • HIV/AIDS drug development and treatment
  • Hermeneutics and Narrative Identity

Among the recent papers featuring Helmut Sigel as an author or co-author are:

  • "Coordination Chemistry of Nucleotides and Antivirally Active Acyclic Nucleoside Phosphonates, including Mechanistic Considerations" (2022) published in Molecules
  • "Acid-base properties of an antivirally active acyclic nucleoside phosphonate: (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA)" (2022) published in New Journal of Chemistry
  • "Spectrum of Disease Severity in Canavan Leukodystrophy" (2024) published in Neuropediatrics
  • "Analysis of Anthropometric Measurements in Children with Canavan Disease" (2024) published in Neuropediatrics
  • "Deep Intronic SVA_E Retrotransposition as a Novel Factor in Canavan Disease Pathogenesis" (2025) published in Human Gene Therapy

Helmut Sigel frequently collaborates with a number of researchers, including:

  • Annette Bley
  • Astrid Sigel
  • Jan Bredow
  • Amanda Nagy
  • Florian Eichler

Their publications appear predominantly in the following venues:

  • Neuropediatrics
  • Molecules
  • New Journal of Chemistry
  • Human Gene Therapy
  • Journal of Clinical Medicine

Best Publications

  • Coordinating properties of the amide bond. Stability and structure of metal ion complexes of peptides and related ligands

    Helmut Sigel;R. Bruce Martin

  • Handbook on toxicity of inorganic compounds

    Hans G. Seiler;Helmut Sigel;Astrid Sigel

  • Handbook on metals in clinical and analytical chemistry

    Hans G. Seiler;Astrid Sigel;Helmut Sigel

  • Interactions of metal ions with nucleotides and nucleic acids and their constituents

    Helmut Sigel

  • Handbook on Metalloproteins

    Ivano Bertini;Astrid Sigel;Helmut Sigel

  • Ternary Cu2+ Complexes: Stability, Structure, and Reactivity

    Helmut Sigel

  • Discriminating behavior of metal ions and ligands with regard to their biological significance

    Helmut Sigel;Donald B. McCormick

  • Comparison of the Extent of Macrochelate Formation in Complexes of Divalent Metal Ions with Guanosine (GMP2-), Inosine (IMP2-), and Adenosine 5'-Monophosphate (AMP2-). The Crucial Role of N-7 Basicity in Metal Ion-Nucleic Base Recognition

    Helmut Sigel;Salah S. Massoud;Nicolas A. Corfu

  • A stability concept for metal ion coordination to single-stranded nucleic acids and affinities of individual sites.

    Roland K. O. Sigel;Helmut Sigel

  • Macrochelate formation in monomeric metal ion complexes of nucleoside 5'-triphosphates and the promotion of stacking by metal ions. Comparison of the self-association of purine and pyrimidine 5'-triphosphates using proton nuclear magnetic resonance

    Kurt H. Scheller;Fritz Hofstetter;Paul R. Mitchell;Bernhard Prijs

  • Interrelations between Essential Metal Ions and Human Diseases

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

  • Ternary complexes in solution. 35. Intramolecular hydrophobic ligand-ligand interactions in mixed ligand complexes containing an aliphatic amino acid

    Beda E. Fischer;Helmut Sigel

  • Ternary complexes in solution. VIII. Complex formation between the copper(II)-2,2'-bipyridyl 1:1 complex and ligands containing oxygen and/or nitrogen donor atoms

    Rolf Griesser;Helmut Sigel

  • Metal ion coordinating properties of pyrimidine-nucleoside 5'-monophosphates (CMP, UMP, TMP) and of simple phosphate monoesters, including D-ribose 5'-monophosphate. Establishment of relations between complex stability and phosphate basicity

    Salah S. Massoud;Helmut Sigel

  • Metal Ions in Life Sciences

    Astrid Sigel;Helmut Sigel;Roland K O Sigel

  • Self-association and protonation of adenosine 5'-monophosphate in comparison with its 2'- and 3'-analogues and tubercidin 5'-monophosphate (7-deaza-AMP).

    Roger Tribolet;Helmut Sigel

  • Comments on potentiometric pH titrations and the relationship between pH-meter reading and hydrogen ion concentration

    Helmut Sigel;Andreas D. Zuberbühler;Osamu Yamauchi

  • Nucleoside 5'-triphosphates: self-association, acid-base, and metal ion-binding properties in solution.

    Unknown

  • Cadmium : from toxicity to essentiality

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

  • Metal ion/buffer interactions. Stability of binary and ternary complexes containing 2-amino-2(hydroxymethyl)-1,3-propanediol (Tris) and adenosine 5'-triphosphate (ATP).

    Beda E. Fischer;Ulrich K. Häring;Roger Tribolet;Helmut Sigel

  • Isomeric equilibria in complexes of adenosine 5′‐triphosphate with divalent metal ions

    Helmut Sigel

  • Metal Ions in Biological Systems

    Helmut Sigel;Roland K O Sigel

Frequent Co-Authors

Roland K. O. Sigel
Roland K. O. Sigel University of Zurich
Antonín Holý
Antonín Holý Czech Academy of Sciences
Bernhard Lippert
Bernhard Lippert TU Dortmund University
R. Bruce Martin
R. Bruce Martin University of Virginia
Virtudes Moreno
Virtudes Moreno University of Barcelona
F. Ann Walker
F. Ann Walker University of Arizona
Henryk Kozlowski
Henryk Kozlowski University of Wrocław
Jens Müller
Jens Müller University of Münster
Paolo Carloni
Paolo Carloni Forschungszentrum Jülich

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