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Neuroscience

D-Index
44
Citations
6915
World Ranking
7208
National Ranking
427

Overview

James G. McLarnon is affiliated with the University of British Columbia in Canada. Their research primarily focuses on the fields of Medicine and Neuroscience, with particular attention to Physiology, Neurology, and Clinical Biochemistry. The core areas of study involve Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, advanced glycation end products research, barrier structure and function studies, medicinal plants and neuroprotection, and neuropeptides and animal physiology.

The scientist has contributed to a range of peer-reviewed journals, with frequent publications appearing in:

  • Current Alzheimer Research (3 publications)
  • Antioxidants (1 publication)
  • arXiv (Cornell University) (1 publication)

Recent papers authored or co-authored by James G. McLarnon include:

  • "A Leaky Blood-Brain Barrier to Fibrinogen Contributes to Oxidative Damage in Alzheimer's Disease" (2021) in Antioxidants
  • "Microglial Store-operated Calcium Signaling in Health and in Alzheimer's Disease" (2021) in Current Alzheimer Research
  • "Glial-derived Neuroinflammation induced with Amyloid-beta-peptide PlusFibrinogen Injection in Rat Hippocampus" (2023) in Current Alzheimer Research

The research collaborations of James G. McLarnon include frequent co-authors such as Andis Klegeris, Sadayuki Hashioka, D. Regan, Magdalena Lipka-Lloyd, and P.J. Rizkallah.

The subfields that James G. McLarnon's work engages with are:

  • Physiology
  • Neurology
  • Clinical Biochemistry
  • Complementary and alternative medicine
  • Cellular and Molecular Neuroscience

The main topics covered in their research are:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Advanced Glycation End Products research
  • Barrier Structure and Function Studies
  • Medicinal Plants and Neuroprotection
  • Neuropeptides and Animal Physiology

Best Publications

  • A leaky blood–brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

    Jae K. Ryu;James G. McLarnon

  • Upregulated Expression of Purinergic P2X7 Receptor in Alzheimer Disease and Amyloid-β Peptide-Treated Microglia and in Peptide-Injected Rat Hippocampus

    James G. McLarnon;Jae K. Ryu;Douglas G. Walker;Hyun B. Choi

  • Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase.

    Hyun B. Choi;Grant R.J. Gordon;Ning Zhou;Ning Zhou;Chao Tai

  • Modulation of the Purinergic P2X7 Receptor Attenuates Lipopolysaccharide-Mediated Microglial Activation and Neuronal Damage in Inflamed Brain

    Hyun B. Choi;Jae K. Ryu;Seung U. Kim;James G. McLarnon

  • Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease.

    Jae K Ryu;Jean Kim;Sung J Cho;Kozo Hatori

  • Generation and characterization of immortalized human microglial cell lines: expression of cytokines and chemokines.

    A. Nagai;E. Nakagawa;K. Hatori;H.B. Choi

  • Minocycline inhibits neuronal death and glial activation induced by beta-amyloid peptide in rat hippocampus.

    Jae K. Ryu;Sonia Franciosi;Prasongchai Sattayaprasert;Seung U. Kim;Seung U. Kim

  • Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein S6 kinase.

    Jae K. Ryu;Hyun B. Choi;Kozo Hatori;Rochelle L. Heisel

  • Human neural stem cells: electrophysiological properties of voltage-gated ion channels.

    T. Cho;J. H. Bae;H. B. Choi;S. S. Kim

  • Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimer's disease

    Jae K. Ryu;James G. McLarnon

  • Microglial VEGF Receptor Response Is an Integral Chemotactic Component in Alzheimer's Disease Pathology

    Jae K. Ryu;Taesup Cho;Hyun B. Choi;Yu Tian Wang

  • Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease.

    Sonia Franciosi;Jae K. Ryu;Yaein Shim;Austin Hill

  • Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum

    Jae K. Ryu;Hyun B. Choi;James G. McLarnon

  • IL-8 enhancement of amyloid-beta (Aβ1-42)-induced expression and production of pro-inflammatory cytokines and COX-2 in cultured human microglia

    Sonia Franciosi;Hyun B. Choi;Seung U. Kim;Seung U. Kim;James G. McLarnon

  • Expression and function of the P2X7 receptor in rat C6 glioma cells

    Wei Wei;Jae K. Ryu;Hyun B. Choi;James G. McLarnon

  • Inhibition of lipopolysaccharide-induced cyclooxygenase-2, tumor necrosis factor-alpha and [Ca2+]i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195.

    Hyan B. Choi;C. Khoo;Jae K. Ryu;Edo Van Breemen

  • Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies.

    Jae K Ryu;Atsushi Nagai;Jean Kim;Jean Kim;Min C Lee;Min C Lee

  • Thalidomide inhibition of perturbed vasculature and glial-derived tumor necrosis factor-α in an animal model of inflamed Alzheimer’s disease brain

    Jae K. Ryu;James G. McLarnon

  • Purinergic mediated changes in Ca2+ mobilization and functional responses in microglia: effects of low levels of ATP.

    James G. McLarnon

  • Combined minocycline plus pyruvate treatment enhances effects of each agent to inhibit inflammation, oxidative damage, and neuronal loss in an excitotoxic animal model of Huntington's disease.

    J.K. Ryu;H.B. Choi;J.G. McLarnon

Frequent Co-Authors

Seung U. Kim
Seung U. Kim University of British Columbia
Andis Klegeris
Andis Klegeris University of British Columbia
Yu Tian Wang
Yu Tian Wang University of British Columbia
Douglas G. Walker
Douglas G. Walker Arizona State University
Edith G. McGeer
Edith G. McGeer University of British Columbia
Blair R. Leavitt
Blair R. Leavitt University of British Columbia
Brian A. MacVicar
Brian A. MacVicar University of British Columbia
Teresa A. Milner
Teresa A. Milner Cornell University

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