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Neuroscience

D-Index
58
Citations
27400
World Ranking
4082
National Ranking
1857

Overview

Abhay P. Sagare is affiliated with the University of Southern California in the United States and primarily conducts research in the fields of Medicine and Neuroscience. Their work focuses on several subfields including Neurology, Physiology, Molecular Biology, Psychiatry and Mental Health, and Radiology, Nuclear Medicine and Imaging.

The scientist's research encompasses a range of topics, notably:

  • Alzheimer's disease research and treatments
  • Barrier Structure and Function Studies
  • Dementia and Cognitive Impairment Research
  • Cerebrovascular and Carotid Artery Diseases
  • Neurological Disease Mechanisms and Treatments
  • Advanced Neuroimaging Techniques and Applications
  • Acute Ischemic Stroke Management

Abhay P. Sagare has contributed to numerous publications, with a significant number appearing in venues such as Alzheimer's & Dementia, Molecular Neurodegeneration, The Journal of Experimental Medicine, bioRxiv (Cold Spring Harbor Laboratory), and Nature.

Notable recent papers include:

  • APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline, 2020, Nature
  • APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β, 2021, Nature Aging
  • Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial, 2020, EBioMedicine
  • Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A, 2021, The Journal of Experimental Medicine
  • Molecular biomarkers for vascular cognitive impairment and dementia, 2023, Nature Reviews Neurology

The scientist's research is supported by frequent collaboration with co-authors such as Berislav V. Zloković, John M. Ringman, Axel Montagne, Kassandra Kisler, and Judy Pa. These collaborations have contributed to a body of work spanning multiple high-impact studies in neurodegeneration and vascular cognitive disorders.

Best Publications

  • Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

    Melanie D. Sweeney;Abhay P. Sagare;Berislav V. Zlokovic

  • Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

    Axel Montagne;Samuel R. Barnes;Melanie D. Sweeney;Matthew R. Halliday

  • Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction.

    Daniel A Nation;Melanie D Sweeney;Axel Montagne;Abhay P Sagare

  • Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging.

    Robert D. Bell;Ethan A. Winkler;Abhay P. Sagare;Itender Singh

  • Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

    Robert D. Bell;Ethan A. Winkler;Itender Singh;Abhay P. Sagare

  • APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

    Axel Montagne;Daniel A. Nation;Abhay P. Sagare;Giuseppe Barisano

  • LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms

    Rashid Deane;Zhenhua Wu;Abhay Sagare;Judianne Davis

  • apoE isoform-specific disruption of amyloid β peptide clearance from mouse brain

    Rashid Deane;Abhay Sagare;Katie Hamm;Margaret Parisi

  • Transport pathways for clearance of human Alzheimer's amyloid β-peptide and apolipoproteins E and J in the mouse central nervous system

    Robert D Bell;Abhay P Sagare;Alan E Friedman;Gurrinder S Bedi

  • P-glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mouse model

    John R. Cirrito;Rashid Deane;Anne M. Fagan;Michael L. Spinner

  • Vascular dysfunction-The disregarded partner of Alzheimer's disease

    Melanie D. Sweeney;Axel Montagne;Abhay P. Sagare;Daniel A. Nation

  • A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

    Rashid Deane;Itender Singh;Abhay P. Sagare;Robert D. Bell

  • GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

    Ethan A Winkler;Ethan A Winkler;Yoichiro Nishida;Yoichiro Nishida;Abhay P Sagare;Sanket V Rege

  • Pericyte loss influences Alzheimer-like neurodegeneration in mice.

    Abhay P. Sagare;Robert D. Bell;Zhen Zhao;Qingyi Ma

  • Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease.

    Amy R. Nelson;Melanie D. Sweeney;Abhay P. Sagare;Berislav V. Zlokovic

  • Clearance of amyloid-β by circulating lipoprotein receptors

    Abhay Sagare;Rashid Deane;Robert D. Bell;Bradley Johnson

  • Clearance of amyloid-β peptide across the blood-brain barrier: Implication for therapies in Alzheimer’s disease

    R. Deane;R. D. Bell;A. Sagare;B. V. Zlokovic

  • ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

    Zhihui Zhong;Rashid Deane;Zarina Ali;Margaret Parisi

  • Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

    Zhen Zhao;Abhay P Sagare;Qingyi Ma;Matthew R Halliday

  • Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss.

    Angeliki M Nikolakopoulou;Axel Montagne;Kassandra Kisler;Zhonghua Dai

  • IgG-Assisted Age-Dependent Clearance of Alzheimer's Amyloid β Peptide by the Blood–Brain Barrier Neonatal Fc Receptor

    Rashid Deane;Abhay Sagare;Katie Hamm;Margaret Parisi

Frequent Co-Authors

Berislav V. Zlokovic
Berislav V. Zlokovic University of Southern California
Arthur W. Toga
Arthur W. Toga University of Southern California
Michael G. Harrington
Michael G. Harrington University of Southern California
Helena C. Chui
Helena C. Chui University of Southern California
Hsin-Sheng Tsay
Hsin-Sheng Tsay Chaoyang University of Technology
John C. Morris
John C. Morris Washington University in St. Louis
Tammie L.S. Benzinger
Tammie L.S. Benzinger Washington University in St. Louis
Russell E. Jacobs
Russell E. Jacobs University of Southern California
David M. Holtzman
David M. Holtzman Washington University in St. Louis
Julie A. Schneider
Julie A. Schneider Rush University Medical Center

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