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Molecular Biology

D-Index
64
Citations
13635
World Ranking
1753
National Ranking
140

Overview

Peter Karran is affiliated with The Francis Crick Institute in the United Kingdom. Their research primarily focuses on biochemistry, genetics, and molecular biology, with an emphasis on molecular biology, cancer research, and aging.

Their work covers several main topics including DNA repair mechanisms, carcinogens and genotoxicity assessment, mitochondrial function and pathology, and genetics, aging, and longevity in model organisms.

Among the recent papers authored in collaboration with frequent co-authors, two works stand out:

  • Young transgenic hMTH1 mice are protected against dietary fat-induced metabolic stress-implications for enhanced longevity, 2022, Aging Cell
  • Mutation and aging: news from the pool, 2023, Aging

Frequent co-authors include Francesca Marcon, Margherita Bignami, Roberta Meschini, Egidio Iorio, and Simonetta Palleschi.

Peter Karran's publications have appeared in journals such as Aging Cell and Aging.

Best Publications

  • Azathioprine and UVA Light Generate Mutagenic Oxidative DNA Damage

    Peter O'Donovan;Conal M. Perrett;Xiaohong Zhang;Beatriz Montaner

  • DNA double strand break repair in mammalian cells.

    Peter Karran

  • Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer

    Peter Karran;Natalie Attard

  • Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

    P Branch;G Aquilina;M Bignami;P Karran

  • DNA DAMAGE TOLERANCE, MISMATCH REPAIR AND GENOME INSTABILITY

    P. Karran;M. Bignami

  • DNA excision repair pathways

    Tomas Lindahl;Peter Karran;Richard D Wood

  • Mechanisms of tolerance to DNA damaging therapeutic drugs.

    Peter Karran

  • Mismatch correction at O6-methylguanine residues in E. coli DNA.

    Peter Karran;Martin G. Marinus

  • The Mammalian Mismatch Repair Pathway Removes DNA 8-oxodGMP Incorporated from the Oxidized dNTP Pool

    Claudia Colussi;Eleonora Parlanti;Paolo Degan;Gabriele Aquilina

  • Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents

    M. Bignami;M. O'Driscoll;G. Aquilina;P. Karran

  • Hypoxanthine in deoxyribonucleic acid: generation by heat-induced hydrolysis of adenine residues and release in free form by a deoxyribonucleic acid glycosylase from calf thymus

    Peter Karran;Tomas Lindahl

  • Vanillins—a novel family of DNA‐PK inhibitors

    Stephen Durant;Peter Karran

  • Thiopurines, DNA damage, DNA repair and therapy-related cancer

    Peter Karran

  • Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.

    P Karran;M Bignami

  • Treatment of post-transplant premalignant skin disease: a randomized intrapatient comparative study of 5-fluorouracil cream and topical photodynamic therapy

    C. M. Perrett;J. M. McGregor;Jane Warwick;P. Karran

  • Selective Recognition of a Cisplatin-DNA Adduct By Human Mismatch Repair Proteins

    Masami Yamada;Edel O'Regan;Robert Brown;Peter Karran

  • Azathioprine treatment photosensitizes human skin to ultraviolet A radiation.

    C. M. Perrett;C. M. Perrett;S.L. Walker;P. O’Donovan;Jane Warwick

  • Selection for β2-microglobulin mutation in mismatch repair-defective colorectal carcinomas

    David C. Bicknell;Loukas Kaklamanis;Richard Hampson;Walter F. Bodmer

  • The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells.

    Maria Teresa Russo;Monica Francesca Blasi;Federica Chiera;Paola Fortini

  • Differential Human Nucleotide Excision Repair of Paired and Mispaired Cisplatin-DNA Adducts

    Jonathan G. Moggs;David E. Szymkowski;Masami Yamada;Peter Karran

Frequent Co-Authors

Margherita Bignami
Margherita Bignami Istituto Superiore di Sanità
Walter F. Bodmer
Walter F. Bodmer University of Oxford
Mark O'Driscoll
Mark O'Driscoll University of Sussex
Eugenia Dogliotti
Eugenia Dogliotti Istituto Superiore di Sanità
Tomas Lindahl
Tomas Lindahl The Francis Crick Institute
Michael H.L. Green
Michael H.L. Green University of Brighton
Livio Pagano
Livio Pagano Catholic University of the Sacred Heart
Jean-Marc Egly
Jean-Marc Egly Institute of Genetics and Molecular and Cellular Biology
Richard D. Wood
Richard D. Wood The University of Texas MD Anderson Cancer Center
Giuseppe Leone
Giuseppe Leone Catholic University of the Sacred Heart

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