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Biology and Biochemistry

D-Index
57
Citations
11910
World Ranking
13823
National Ranking
249

Overview

Giancarlo Marra is affiliated with the University of Zurich in Switzerland and has contributed extensively to research in the fields of biochemistry, genetics, molecular biology, and medicine. Their work spans a variety of subfields including molecular biology, cancer research, oncology, genetics, and pulmonary and respiratory medicine.

The scientist's primary research topics include epigenetics and DNA methylation, genetic factors in colorectal cancer, colorectal cancer screening and detection, cancer-related molecular mechanisms, renal cell carcinoma treatment, cancer genomics and diagnostics, as well as the interplay of cancer, hypoxia, and metabolism.

Recent scholarly publications by Giancarlo Marra encompass a range of studies in oncology and molecular biology. Notable papers are:

  • Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice, 2020, Journal of Clinical Investigation
  • Functional Analysis Identifies Damaging CHEK2 Missense Variants Associated with Increased Cancer Risk, 2021, Cancer Research
  • DAMEfinder: a method to detect differential allele-specific methylation, 2020, Epigenetics & Chromatin
  • The DNA hypermethylation phenotype of colorectal cancer liver metastases resembles that of the primary colorectal cancers, 2020, BMC Cancer
  • Transrectal versus transperineal prostate fusion biopsy: a pair-matched analysis to evaluate accuracy and complications, 2024, World Journal of Urology

Collaboration is a significant aspect of Marra's career, with frequent co-authors including Paolo Gontero, Stephany Orjuela, Mark D. Robinson, Giorgio Calleris, and Marco Oderda. These collaborations likely span several aspects of cancer research and molecular diagnostics.

Giancarlo Marra's research has been published repeatedly in prominent venues, with multiple publications in journals such as:

  • BMC Cancer
  • World Journal of Urology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Urology
  • Research Square (Research Square)

The breadth of Marra's research reflects an intersection of genetics and cancer biology, with an emphasis on the molecular mechanisms underlying cancer and its detection, notably colorectal and renal cell carcinomas. This work contributes to understanding genetic variants related to cancer risk and epigenetic changes that characterize cancer progression and metastasis.

Best Publications

  • Hereditary Nonpolyposis Colorectal Cancer: the Syndrome, the Genes, and Historical Perspectives

    Giancarlo Marra;C R Boland

  • The Intestinal Wnt/TCF Signature.

    Laurens G. Van der Flier;Jacob Sabates–Bellver;Irma Oving;Andrea Haegebarth

  • Transcriptome Profile of Human Colorectal Adenomas

    Jacob Sabates-Bellver;Laurens G Van der Flier;Mariagrazia de Palo;Elisa Cattaneo

  • Evidence for a Connection between the Mismatch Repair System and the G2 Cell Cycle Checkpoint

    M. T. Hawn;Asad Umar;J. M. Carethers;G. Marra

  • Conversion of diploidy to haploidy

    Hai Yan;Nickolas Papadopoulos;Giancarlo Marra;Claudia Perrera

  • hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci.

    Hanna E. Kleczkowska;Giancarlo Marra;Teresa Lettieri;Teresa Lettieri;Josef Jiricny

  • JC virus DNA is present in the mucosa of the human colon and in colorectal cancers

    L Laghi;A E Randolph;D P Chauhan;G Marra

  • Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase

    Lovorka Stojic;Nina Mojas;Petr Cejka;Massimiliano di Pietro

  • Oxidative stress inactivates the human DNA mismatch repair system

    Christina L. Chang;Giancarlo Marra;Dharam P. Chauhan;Hannah T. Ha

  • Effect of ω-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer

    Marcello Anti;Giancarlo Marra;Franco Armelao;Gianna Maria Bartoli

  • Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system.

    Joerg Trojan;Stefan Zeuzem;Ann Randolph;Christine Hemmerle

  • Effects of Different Doses of Fish Oil on Rectal Cell Proliferation in Patients With Sporadic Colonic Adenomas

    Marcello Anti;Franco Armelao;Giancarlo Marra;Antonio Percesepe

  • Mismatch repair deficiency associated with overexpression of the MSH3 gene

    Giancarlo Marra;Ingram Iaccarino;Teresa Lettieri;Giuseppe Roscilli

  • Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis

    Ronja Adam;Isabel Spier;Bixiao Zhao;Michael Kloth

  • Methylation‐induced G2/M arrest requires a full complement of the mismatch repair protein hMLH1

    Petr Cejka;Lovorka Stojic;Nina Mojas;Anna Marie Russell

  • Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1.

    Markus Räschle;Giancarlo Marra;Minna Nyström-Lahti;Primo Schär

  • Immunohistochemical analysis reveals high frequency of PMS2 defects in colorectal cancer.

    Kaspar Truninger;Mirco Menigatti;Judith Luz;Anna Russell

  • hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha.

    Ingram Iaccarino;Giancarlo Marra;Fabio Palombo;Josef Jiricny

  • Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.

    J M Carethers;M T Hawn;D P Chauhan;M C Luce

  • Expression of the MutL Homologue hMLH3 in Human Cells and its Role in DNA Mismatch Repair

    Elda Cannavo;Giancarlo Marra;Jacob Sabates-Bellver;Mirco Menigatti

Frequent Co-Authors

Josef Jiricny
Josef Jiricny University of Zurich
Morgan Rouprêt
Morgan Rouprêt Université Paris Cité
Alexandre de la Taille
Alexandre de la Taille Université Paris Cité
Steven Joniau
Steven Joniau KU Leuven
Inderbir S. Gill
Inderbir S. Gill University of Southern California
Declan G. Murphy
Declan G. Murphy King's College London
Prokar Dasgupta
Prokar Dasgupta King's College London
Joseph A. Smith
Joseph A. Smith Vanderbilt University Medical Center
Mark D. Robinson
Mark D. Robinson University of Zurich

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