World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
78
Citations
68402
World Ranking
4423
National Ranking
14

Overview

Nick Barker is affiliated with the Agency for Science, Technology and Research in Singapore. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on molecular biology, oncology, surgery, genetics, and pulmonary and respiratory medicine. The scientist's work primarily addresses topics related to cancer cells and metastasis, digestive system health, pluripotent stem cells research, epigenetics and DNA methylation, Helicobacter pylori-related gastroenterology studies, cancer genomics and diagnostics, and gut microbiota and health.

Notable papers authored by Nick Barker include:

  • Cell transcriptomic atlas of the non-human primate Macaca fascicularis, 2022, Nature
  • AQP5 enriches for stem cells and cancer origins in the distal stomach, 2020, Nature
  • A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers, 2021, Nature Cell Biology
  • A constant pool of Lgr5+ intestinal stem cells is required for intestinal homeostasis, 2021, Cell Reports
  • A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells, 2021, Proceedings of the National Academy of Sciences

Frequent co-authors collaborating with Nick Barker are:

  • Hui Yi Grace Lim
  • Swathi Yada
  • Kazuhiro Murakami
  • Sowmya Sagiraju
  • Bernett Lee

Nick Barker's research has appeared in multiple publication venues including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • Nature Cancer
  • Gastroenterology
  • Nature

Best Publications

  • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.

    Toshiro Sato;Robert G J Vries;Hugo J. Snippert;Marc van de Wetering

  • Identification of stem cells in small intestine and colon by marker gene Lgr5

    Nick Barker;Johan H. van Es;Jeroen Kuipers;Pekka Kujala

  • Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

    Patrice J. Morin;Andrew B. Sparks;Vladimir Korinek;Nick Barker

  • The zebrafish reference genome sequence and its relationship to the human genome.

    Kerstin Howe;Matthew D. Clark;Carlos F. Torroja;Carlos F. Torroja;James Torrance

  • Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma

    Vladimir Korinek;Nick Barker;Patrice J. Morin;Dick van Wichen

  • Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

    Toshiro Sato;Johan H. van Es;Hugo J. Snippert;Daniel E. Stange

  • Crypt stem cells as the cells-of-origin of intestinal cancer

    Nick Barker;Rachel A. Ridgway;Johan H. Van Es;Marc Van De Wetering

  • Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

    Hugo J. Snippert;Laurens G. van der Flier;Toshiro Sato;Johan H. van Es

  • Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4.

    V Korinek;N Barker;P Moerer;E van Donselaar

  • Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

    Nick Barker;Meritxell Huch;Pekka Kujala;Marc van de Wetering

  • Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

    Wim De Lau;Nick Barker;Nick Barker;Teck Y. Low;Bon Kyoung Koo

  • Organoids as an in vitro model of human development and disease

    Aliya Fatehullah;Si Hui Tan;Nick Barker;Nick Barker;Nick Barker

  • Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

    Nick Barker

  • Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

    Sarah Schwitalla;Alexander A. Fingerle;Patrizia Cammareri;Tim Nebelsiek

  • Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

    Viljar Jaks;Nick Barker;Maria Kasper;Johan H. van Es

  • Mining the Wnt pathway for cancer therapeutics

    Nick Barker;Hans Clevers

  • Functional interaction between beta-catenin and FOXO in oxidative stress signaling.

    Marieke A. G. Essers;Lydia M. M. de Vries-Smits;Nick Barker;Paulien E. Polderman

  • Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

    Hugo J. G. Snippert;Andrea Haegebarth;Maria Kasper;Viljar Jaks

  • Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

    Johan H. van Es;Toshiro Sato;Marc van de Wetering;Anna Lyubimova

  • The intestinal stem cell

    Nick Barker;Marc van de Wetering;Hans Clevers

Frequent Co-Authors

Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Owen J. Sansom
Owen J. Sansom University of Glasgow
Johan H. van Es
Johan H. van Es Utrecht University
Marc van de Wetering
Marc van de Wetering Royal Netherlands Academy of Arts and Sciences
Peter J. Peters
Peter J. Peters Maastricht University
Daniel K. Podolsky
Daniel K. Podolsky The University of Texas at Dallas
Toshiro Sato
Toshiro Sato Keio University
Rune Toftgård
Rune Toftgård Karolinska Institute
Alexander van Oudenaarden
Alexander van Oudenaarden University Medical Center Utrecht
Irene M. Leigh
Irene M. Leigh University of Dundee

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring a degree in Biology or Biochemistry opens doors to a wide range of related online programs and career opportunities in the health sciences. Many students are drawn to complementary pathways that offer flexibility and a strong return on investment.

For those interested in leadership or administrative roles, an accelerated healthcare management degree online is a popular choice. This option is perfect for students aiming for managerial positions in hospitals or research facilities. Alternatively, an cheapest online mba healthcare management can boost business skills while remaining budget-friendly.

If you are passionate about mental health and direct patient care, advanced nursing degrees like psychiatric np programs allow biology graduates to specialize further and address the growing need for psychiatric nurse practitioners.

For students seeking a nutrition-based career, a fast track nutrition degree online provides a gateway to jobs in research, wellness, and clinical nutrition. Exploring these related degrees helps you discover specialized fields that build on a strong foundation in biology and biochemistry.

Best Scientists Citing Nick Barker

Trending Scientists

Recently Published Articles