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Biology and Biochemistry

D-Index
70
Citations
58327
World Ranking
6827
National Ranking
178

Overview

Marc van de Wetering is a researcher affiliated with the Royal Netherlands Academy of Arts and Sciences in the Netherlands. Their work spans multiple fields, primarily focusing on Medicine and Biochemistry, Genetics and Molecular Biology. The subfields in which they have made contributions include Molecular Biology, Oncology, Pulmonary and Respiratory Medicine, Cancer Research, and Immunology.

The main topics of Marc van de Wetering's research address areas such as Cancer Cells and Metastasis, Sarcoma Diagnosis and Treatment, Cancer Genomics and Diagnostics, 3D Printing in Biomedical Research, Glioma Diagnosis and Treatment, CAR-T cell therapy research, and Chromatin Remodeling and Cancer.

Their recent publications cover a range of studies in high-impact scientific journals. These include:

  • Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors, 2022, Nature Cancer
  • Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype, 2021, Proceedings of the National Academy of Sciences
  • Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes, 2022, EMBO Molecular Medicine
  • Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation, 2023, Science
  • Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities, 2023, Oncogene

Collaborations have played a significant role in Marc van de Wetering's research. Frequent co-authors include Hans Clevers, Femke Ringnalda, Jan J. Molenaar, Thanasis Margaritis, and Jeff DeMartino.

Their publications appear in a variety of scientific venues, with a notable number in Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Neuro-Oncology, Nature Cancer, and Proceedings of the National Academy of Sciences.

Best Publications

  • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.

    Toshiro Sato;Robert G J Vries;Hugo J. Snippert;Marc van de Wetering

  • Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

    Toshiro Sato;Johan H. van Es;Hugo J. Snippert;Daniel E. Stange

  • The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.

    Marc van de Wetering;Elena Sancho;Cornelis Verweij;Wim de Lau

  • Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

    Marc van de Wetering;Hayley E. Francies;Joshua M. Francis;Joshua M. Francis;Gergana Bounova

  • Crypt stem cells as the cells-of-origin of intestinal cancer

    Nick Barker;Rachel A. Ridgway;Johan H. Van Es;Marc Van De Wetering

  • XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

    Miranda Molenaar;Marc van de Wetering;Mariette Oosterwegel;Josi Peterson-Maduro

  • A promoter-level mammalian expression atlas

    Alistair R.R. Forrest;Hideya Kawaji;Michael Rehli;J. Kenneth Baillie

  • Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

    Nick Barker;Meritxell Huch;Pekka Kujala;Marc van de Wetering

  • Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

    Meritxell Huch;Helmuth Gehart;Ruben van Boxtel;Karien Hamer

  • In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

    Meritxell Huch;Craig Dorrell;Sylvia F. Boj;Johan H. van Es

  • Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF

    Marc van de Wetering;Robert Cavallo;Dennis Dooijes;Moniek van Beest

  • Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

    Wim De Lau;Nick Barker;Nick Barker;Teck Y. Low;Bon Kyoung Koo

  • β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB

    Eduard Batlle;Jeffrey T. Henderson;Harry Beghtel;Maaike M.W. van den Born

  • Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

    Arnout G. Schepers;Hugo J. Snippert;Daniel E. Stange;Maaike van den Born

  • Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

    Barbara Lustig;Boris Jerchow;Martin Sachs;Sigrid Weiler

  • Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.

    Bon-Kyoung Koo;Maureen Spit;Ingrid Jordens;Teck Y. Low

  • Sequential cancer mutations in cultured human intestinal stem cells

    Jarno Drost;Richard H. van Jaarsveld;Bas Ponsioen;Cheryl Zimberlin

  • Tissue-specific mutation accumulation in human adult stem cells during life

    Francis Blokzijl;Joep de Ligt;Myrthe Jager;Valentina Sasselli

  • Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

    Hugo J. G. Snippert;Andrea Haegebarth;Maria Kasper;Viljar Jaks

  • Single-cell dissection of transcriptional heterogeneity in human colon tumors

    Piero Dalerba;Tomer Kalisky;Debashis Sahoo;Pradeep S Rajendran

Frequent Co-Authors

Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Johan H. van Es
Johan H. van Es Utrecht University
Nick Barker
Nick Barker Agency for Science, Technology and Research
Alexander van Oudenaarden
Alexander van Oudenaarden University Medical Center Utrecht
Toshiro Sato
Toshiro Sato Keio University
Edwin Cuppen
Edwin Cuppen Utrecht University
Peter J. Peters
Peter J. Peters Maastricht University
Juha Kere
Juha Kere Karolinska Institute
Frank Brombacher
Frank Brombacher University of Cape Town
Peter Heutink
Peter Heutink German Center for Neurodegenerative Diseases

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