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Genetics and Molecular Biology
Germany
2024
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Molecular Biology
Germany
2023

D-Index & Metrics

Molecular Biology

D-Index
121
Citations
71241
World Ranking
246
National Ranking
21

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Germany Leader Award
  • 2023 - Research.com Molecular Biology in Germany Leader Award
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Walter Birchmeier is affiliated with the Max Delbrück Center for Molecular Medicine in Germany. Their research focuses primarily on the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions to Medicine. The main subfields Birchmeier has worked in include Molecular Biology, Cardiology and Cardiovascular Medicine, Oncology, Cell Biology, and Complementary and alternative medicine.

The scientist's research topics cover a diverse range of areas. These include:

  • Epigenetics and DNA Methylation
  • Cardiovascular Effects of Exercise
  • Hippo pathway signaling and YAP/TAZ
  • Cancer-related gene regulation
  • Cancer Cells and Metastasis
  • Wnt/β-catenin signaling in development and cancer
  • Renal and related cancers

Birchmeier has published extensively in several scientific venues. The most frequent publication venues include:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • PLoS ONE
  • Cancer Research

Among notable recent papers authored or co-authored by Birchmeier are:

  • "Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients" (2020, Nature Communications)
  • "YAP and β-Catenin Cooperate to Drive Oncogenesis in Basal Breast Cancer" (2021, Cancer Research)
  • "Tracing tumorigenesis in a solid tumor model at single-cell resolution" (2020, Nature Communications)
  • "The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness" (2020, Nature Communications)
  • "High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53" (2021, Proceedings of the National Academy of Sciences)

Birchmeier collaborates frequently with several co-authors, including:

  • Séverine Kunz
  • Elena Sommariva
  • Hazel M. Quinn
  • Regina Vogel
  • Oliver Popp

Walter Birchmeier has been recognized as a member of the European Molecular Biology Organization (EMBO), an indication of involvement in the broader European research community. The scientist remains active and contributes to advancing understanding in molecular medicine and oncology, particularly in signaling pathways related to cancer development and cardiovascular health.

Best Publications

  • Functional interaction of beta-catenin with the transcription factor LEF-1.

    Behrens J;von Kries Jp;Kühl M;Bruhn L;Bruhn L

  • Met, metastasis, motility and more

    Carmen Birchmeier;Walter Birchmeier;Ermanno Gherardi;George F. Vande Woude

  • A human protein-protein interaction network : a resource for annotating the proteome

    Ulrich Stelzl;Uwe Worm;Maciej Lalowski;Christian Haenig

  • E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

    U H Frixen;J Behrens;M Sachs;G Eberle

  • Wnt signalling and its impact on development and cancer

    Alexandra Klaus;Walter Birchmeier

  • Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.

    Jürgen Behrens;Boris-Alexander Jerchow;Boris-Alexander Jerchow;Martin Würtele;Martin Würtele;Jan Grimm;Jan Grimm

  • beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin.

    Joerg Huelsken;Regina Vogel;Bettina Erdmann;George Cotsarelis

  • Targeting MET in cancer: rationale and progress

    Ermanno Gherardi;Ermanno Gherardi;Walter Birchmeier;Carmen Birchmeier;George Vande Woude

  • Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness.

    Walter Birchmeier;Jürgen Behrens

  • Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

    J Behrens;M M Mareel;F M Van Roy;W Birchmeier

  • Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

    J Behrens;L Vakaet;R Friis;E Winterhager

  • Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes

    Theo P. Hill;Daniela Später;Makoto M. Taketo;Walter Birchmeier

  • Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

    Barbara Lustig;Boris Jerchow;Martin Sachs;Sigrid Weiler

  • Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

    Yasuyuki Fujita;Gerd Krause;Martin Scheffner;Dietmar Zechner

  • Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

    K M Weidner;J Behrens;J Vandekerckhove;W Birchmeier

  • Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy

    Brenda Gerull;Brenda Gerull;Arnd Heuser;Arnd Heuser;Thomas Wichter;Matthias Paul

  • E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

    J Hülsken;W Birchmeier;J Behrens

  • Balancing cell adhesion and Wnt signaling, the key role of beta-catenin.

    Felix H Brembeck;Marta Rosário;Walter Birchmeier

  • Requirement for beta-catenin in anterior-posterior axis formation in mice.

    Joerg Huelsken;Regina Vogel;Volker Brinkmann;Bettina Erdmann

  • Erratum: Targeting MET in cancer: rationale and progress

    Ermanno Gherardi;Walter Birchmeier;Carmen Birchmeier;George Vande Woude

Frequent Co-Authors

Jürgen Behrens
Jürgen Behrens University of Erlangen-Nuremberg
Carmen Birchmeier
Carmen Birchmeier Max Delbrück Center for Molecular Medicine
Martin Sachs
Martin Sachs University of Erlangen-Nuremberg
Makoto Mark Taketo
Makoto Mark Taketo Kyoto University
Volker Brinkmann
Volker Brinkmann Max Planck Society
Ermanno Gherardi
Ermanno Gherardi University of Pavia
Achim Leutz
Achim Leutz Max Delbrück Center for Molecular Medicine
Peter M. Schlag
Peter M. Schlag Charité - University Medicine Berlin
Udo Heinemann
Udo Heinemann Max Delbrück Center for Molecular Medicine
Amparo Cano
Amparo Cano Spanish National Research Council

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