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Medicine

D-Index
88
Citations
27262
World Ranking
13200
National Ranking
12

Overview

Raquel Seruca is affiliated with the University of Porto in Portugal and has a research profile concentrated in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work covers 29 publications in the former field and 20 in the latter, with a significant focus on molecular and cellular mechanisms related to cancer.

The main subfields of study include Molecular Biology, Cell Biology, Oncology, Pathology and Forensic Medicine, and Immunology and Allergy. These areas frame the various dimensions of their research involving cellular function and disease pathology.

Raquel Seruca's research topics address several key areas, including:

  • Wnt/β-catenin signaling in development and cancer
  • Genetic factors in colorectal cancer
  • Cellular Mechanics and Interactions
  • Cancer-related gene regulation
  • Cancer Cells and Metastasis
  • Cell Adhesion Molecules Research
  • Peptidase Inhibition and Analysis

Their publication record includes contributions to various scientific journals, with recurrent appearances in:

  • Cancers
  • Scientific Reports
  • Cells
  • Cancer Research
  • The Lancet Oncology

Notable recent papers by Raquel Seruca include:

  • Hereditary diffuse gastric cancer: updated clinical practice guidelines, 2020, The Lancet Oncology
  • E-cadherin deregulation in breast cancer, 2020, Journal of Cellular and Molecular Medicine
  • The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression, 2020, Cells
  • Hereditary Gastric and Breast Cancer Syndromes Related to CDH1 Germline Mutation: A Multidisciplinary Clinical Review, 2020, Cancers
  • Integrin β1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells, 2021, Gastric Cancer

The scientist collaborates frequently with several co-authors, highlighting research partnerships with:

  • Joana Figueiredo
  • Patrícia Carneiro
  • Soraia Melo
  • Maria Sofia Fernandes
  • Fátima Carneiro

Best Publications

  • BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC

    Paula Soares;Vítor Trovisco;Ana Sofia Rocha;Jorge Lima

  • Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.

    P Peltomäki;R A Lothe;L A Aaltonen;L Pylkkänen

  • Helicobacter pylori and Interleukin 1 Genotyping: An Opportunity to Identify High-Risk Individuals for Gastric Carcinoma

    Céu Figueiredo;José Carlos Machado;Paul Pharoah;Raquel Seruca

  • Familial gastric cancer: overview and guidelines for management*

    Carlos Caldas;Fatima Carneiro;Henry T Lynch;Jun Yokota

  • Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR.

    Nirosha Suraweera;Alex Duval;Maryline Reperant;Christelle Vaury

  • A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma

    José Carlos Machado;Céu Figueiredo;Paulo Canedo;Paul Pharoah

  • Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.

    Rachel S van der Post;Ingrid P Vogelaar;Fátima Carneiro;Parry Guilford

  • Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma.

    José Carlos Machado;Paul Pharoah;Sónia Sousa;Ralph Carvalho

  • Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations.

    David G. Huntsman;Fatima Carneiro;Frank R. Lewis;Patrick M. MacLeod

  • Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria

    A R Brooks-Wilson;P Kaurah;G Suriano;S Leach

  • The prevalence of PIK3CA mutations in gastric and colon cancer

    Sérgia Velho;Carla Oliveira;Ana Ferreira;António Carlos Ferreira

  • Identification of Germ-Line E-cadherin Mutations in Gastric Cancer Families of European Origin

    Simon A. Gayther;Kylie L. Gorringe;Susan J. Ramus;David Huntsman

  • Familial gastric cancer: genetic susceptibility, pathology, and implications for management.

    Carla Oliveira;Hugo Pinheiro;Joana Figueiredo;Raquel Seruca

  • BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing

    E Domingo;P Laiho;M Ollikainen;M Pinto

  • KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program

    J. H. J. M. van Krieken;A. Jung;T. Kirchner;F. Carneiro

  • E-cadherin gene ( CDH1 ) promoter methylation as the second hit in sporadic diffuse gastric carcinoma

    Jc Machado;C Oliveira;R Carvalho;P Soares

  • Hereditary Diffuse Gastric Cancer: Updated Clinical Practice Guidelines

    Vanessa R. Blair;Maybelle McLeod;Fátima Carneiro;Daniel G. Coit

  • Epithelial E- and P-cadherins: Role and clinical significance in cancer

    Joana Paredes;Joana Figueiredo;André Albergaria;Patrícia Oliveira

  • Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening.

    Fátima Carneiro;Fátima Carneiro;David G Huntsman;Thomas C Smyrk;David A Owen

  • KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression

    C Oliveira;S Velho;C Moutinho;A Ferreira

Frequent Co-Authors

Fátima Carneiro
Fátima Carneiro University of Porto
Carla Oliveira
Carla Oliveira University of Porto
Manuel Sobrinho-Simões
Manuel Sobrinho-Simões University of Porto
Fernando Schmitt
Fernando Schmitt University of Porto
Paula Soares
Paula Soares University of Porto
David G. Huntsman
David G. Huntsman University of British Columbia
Celso A. Reis
Celso A. Reis University of Porto
Carlos Caldas
Carlos Caldas University of Cambridge
Robert M.W. Hofstra
Robert M.W. Hofstra Erasmus University Rotterdam
Lauri A. Aaltonen
Lauri A. Aaltonen University of Helsinki

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