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Biology and Biochemistry

D-Index
70
Citations
31894
World Ranking
6848
National Ranking
496

Overview

Jürgen Behrens is a researcher affiliated with the University of Erlangen-Nuremberg in Germany, specializing in biochemistry, genetics, and molecular biology with a focus on molecular biology and immunology and allergy as subfields. Their work spans several interconnected topics including Wnt/β-catenin signaling in development and cancer, RNA research and splicing, cancer-related gene regulation, and cell adhesion molecules research.

Their publication record includes notable recent papers, with topics centered on signaling pathways and their implications for cancer and cellular processes. These papers include:

  • "Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth" (2022, Nature Communications)
  • "Endogenous oligomer formation underlies DVL2 condensates and promotes Wnt/β-catenin signaling" (2024, bioRxiv (Cold Spring Harbor Laboratory))
  • "Endogenous oligomer formation underlies DVL2 condensates and promotes Wnt/β-catenin signaling" (2024, eLife)

Jürgen Behrens collaborates frequently with several coauthors. These include Martina K. Brückner, Dominic B. Bernkopf, Senem Ntourmas, Martin M. Sachs, and Petra Paclíková, reflecting sustained collaborative efforts in their research endeavors.

Their work is published primarily in venues such as eLife, Nature Communications, and bioRxiv (Cold Spring Harbor Laboratory), indicating active engagement with leading journals in the biomedical research community. Their publications demonstrate a consistent focus on signaling pathways related to cancer biology and molecular regulation.

The main fields of study highlighted in Jürgen Behrens's work reflect a strong emphasis on the molecular mechanisms underlying cellular communication and gene regulation. Their research contributions encompass:

  • Biochemistry, Genetics and Molecular Biology
  • Molecular Biology
  • Immunology and Allergy

The main topics covered in their academic output include:

  • Wnt/β-catenin signaling in development and cancer
  • RNA Research and Splicing
  • Cancer-related gene regulation
  • Cell Adhesion Molecules Research

Best Publications

  • Functional interaction of beta-catenin with the transcription factor LEF-1.

    Behrens J;von Kries Jp;Kühl M;Bruhn L;Bruhn L

  • E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

    U H Frixen;J Behrens;M Sachs;G Eberle

  • Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.

    Jürgen Behrens;Boris-Alexander Jerchow;Boris-Alexander Jerchow;Martin Würtele;Martin Würtele;Jan Grimm;Jan Grimm

  • Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness.

    Walter Birchmeier;Jürgen Behrens

  • Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

    J Behrens;M M Mareel;F M Van Roy;W Birchmeier

  • Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

    J Behrens;L Vakaet;R Friis;E Winterhager

  • Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

    Barbara Lustig;Boris Jerchow;Martin Sachs;Sigrid Weiler

  • Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

    Yasuyuki Fujita;Gerd Krause;Martin Scheffner;Dietmar Zechner

  • Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

    K M Weidner;J Behrens;J Vandekerckhove;W Birchmeier

  • E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

    J Hülsken;W Birchmeier;J Behrens

  • E-Cadherin Expression in Squamous Cell Carcinomas of Head and Neck: Inverse Correlation with Tumor Dedifferentiation and Lymph Node Metastasis

    Jörg H. Schipper;Uwe H. Frixen;Jürgen Behrens;Andreas Unger

  • Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

    K. Michael Weidner;K. Michael Weidner;Silvana Di Cesare;Martin Sachs;Volker Brinkmann

  • The Wnt signaling pathway and its role in tumor development.

    B. Lustig;J. Behrens

  • The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

    Simone Spaderna;Otto Schmalhofer;Mandy Wahlbuhl;Arno Dimmler

  • Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology.

    Jakub M. Swiercz;Rohini Kuner;Jürgen Behrens;Stefan Offermanns

  • Inhibitory action of transforming growth factor beta on endothelial cells

    Gertraud Muller;Jurgen Behrens;Ute Nussbaumer;Peter Bohlen

  • Cadherins and Catenins: Role in Signal Transduction and Tumor Progression

    Jürgen Behrens

  • Biochemical interactions in the wnt pathway.

    Martin J. Seidensticker;Jürgen Behrens

  • Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin.

    J Behrens;W Birchmeier;S L Goodman;B A Imhof

  • The canonical Wnt signalling pathway and its APC partner in colon cancer development

    Jean Schneikert;Jürgen Behrens

Frequent Co-Authors

Walter Birchmeier
Walter Birchmeier Max Delbrück Center for Molecular Medicine
Martin Sachs
Martin Sachs University of Erlangen-Nuremberg
Torsten Pietsch
Torsten Pietsch University of Bonn
Michael Stürzl
Michael Stürzl University of Erlangen-Nuremberg
Florian Lang
Florian Lang University of Tübingen
Michael Föller
Michael Föller University of Hohenheim
Felix B. Engel
Felix B. Engel University of Erlangen-Nuremberg
Dietmar Vestweber
Dietmar Vestweber Max Planck Society
Ludger Klein-Hitpass
Ludger Klein-Hitpass University of Duisburg-Essen
André Reis
André Reis University of Erlangen-Nuremberg

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