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Best Scientists

D-Index
243
Citations
262254
World Ranking
57
National Ranking
1

Molecular Biology

D-Index
244
Citations
274915
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5
National Ranking
1

Medicine

D-Index
247
Citations
277655
World Ranking
38
National Ranking
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Research.com Recognitions

  • 2026 - Research.com Medicine in Netherlands Leader Award
  • 2026 - Research.com Molecular Biology in Netherlands Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Medicine in Netherlands Leader Award
  • 2025 - Research.com Molecular Biology in Netherlands Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Netherlands Leader Award
  • 2023 - Research.com Medicine in Netherlands Leader Award
  • 2023 - Research.com Molecular Biology in Netherlands Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Netherlands Leader Award
  • 2022 - Research.com Medicine in Netherlands Leader Award
  • 2019 - Fellow of the Royal Society, United Kingdom
  • 2019 - Keio Medical Science Prize, Keio University, Tokyo, Japan
  • 2014 - Member of the National Academy of Sciences
  • 2013 - Breakthrough Prize in Life Sciences for describing the role of Wnt signaling in tissue stem cells and cancer.
  • 2012 - William Beaumont Prize, American Gastroenterological Association (AGA)
  • 2009 - Member of Academia Europaea
  • 2001 - Spinoza Prize, Dutch Research Council
  • 2000 - Royal Netherlands Academy of Arts and Sciences
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Hans Clevers is a scientist affiliated with the Hubrecht Institute for Developmental Biology and Stem Cell Research in the Netherlands. Their research spans several fields with a focus on medicine and biochemistry, genetics, and molecular biology. Their work extensively covers molecular biology, oncology, and genetics, as well as specialized areas such as pulmonary and respiratory medicine and cancer research.

The scientist's research topics include cancer cells and metastasis, cancer genomics and diagnostics, 3D printing in biomedical research, pluripotent stem cells research, renal and related cancers, digestive system and related health, and CRISPR and genetic engineering.

Hans Clevers has frequently collaborated with several researchers, including Joep Beumer, Harry Begthel, Johan H. van Es, Peter J. Peters, and Maarten H. Geurts.

Their publications are often found in multiple scientific journals and databases. The most frequent venues for their work are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • University of Groningen research database (University of Groningen / Centre for Information Technology)
  • Cell stem cell
  • Proceedings of the National Academy of Sciences

Selected recent papers include:

  • SARS-CoV-2 productively infects human gut enterocytes, 2020, Science
  • Homeostatic mini-intestines through scaffold-guided organoid morphogenesis, 2020, Nature
  • Cell fate specification and differentiation in the adult mammalian intestine, 2020, Nature Reviews Molecular Cell Biology
  • Establishment of patient-derived cancer organoids for drug-screening applications, 2020, Nature Protocols
  • The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators, 2022, Annual Review of Biochemistry

Hans Clevers has been recognized with several awards throughout their career, including:

  • Fellow of the Royal Society, United Kingdom (2019)
  • Keio Medical Science Prize, Keio University, Tokyo, Japan (2019)
  • Member of the National Academy of Sciences (2014)
  • Breakthrough Prize in Life Sciences (2013) for describing the role of Wnt signaling in tissue stem cells and cancer
  • William Beaumont Prize, American Gastroenterological Association (AGA) (2012)
  • Member of Academia Europaea (2009)
  • Spinoza Prize, Dutch Research Council (2001)
  • Royal Netherlands Academy of Arts and Sciences (2000)
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • Wnt/beta-catenin signaling in development and disease.

    Hans Clevers

  • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.

    Toshiro Sato;Robert G J Vries;Hugo J. Snippert;Marc van de Wetering

  • Identification of stem cells in small intestine and colon by marker gene Lgr5

    Nick Barker;Johan H. van Es;Jeroen Kuipers;Pekka Kujala

  • Wnt/β-catenin signaling and disease.

    Hans Clevers;Roel Nusse

  • Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

    Patrice J. Morin;Andrew B. Sparks;Vladimir Korinek;Nick Barker

  • Wnt signalling in stem cells and cancer

    Tannishtha Reya;Hans Clevers

  • Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma

    Vladimir Korinek;Nick Barker;Patrice J. Morin;Dick van Wichen

  • Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

    Roel Nusse;Hans Clevers

  • Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.

    Toshiro Sato;Daniel E. Stange;Marc Ferrante;Marc Ferrante;Robert G.J. Vries

  • Modeling Development and Disease with Organoids

    Hans Clevers

  • Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

    Toshiro Sato;Johan H. van Es;Hugo J. Snippert;Daniel E. Stange

  • The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.

    Marc van de Wetering;Elena Sancho;Cornelis Verweij;Wim de Lau

  • Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

    Marc van de Wetering;Hayley E. Francies;Joshua M. Francis;Joshua M. Francis;Gergana Bounova

  • Crypt stem cells as the cells-of-origin of intestinal cancer

    Nick Barker;Rachel A. Ridgway;Johan H. Van Es;Marc Van De Wetering

  • Cancer stem cells revisited

    Eduard Batlle;Hans Clevers

  • XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

    Miranda Molenaar;Marc van de Wetering;Mariette Oosterwegel;Josi Peterson-Maduro

  • The cancer stem cell: premises, promises and challenges

    Hans Clevers

  • Stem cells, self-renewal, and differentiation in the intestinal epithelium.

    Laurens G. van der Flier;Hans Clevers

  • Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

    Hugo J. Snippert;Laurens G. van der Flier;Toshiro Sato;Johan H. van Es

  • Linking Colorectal Cancer to Wnt Signaling

    Mariann Bienz;Hans Clevers

Frequent Co-Authors

Marc van de Wetering
Marc van de Wetering Royal Netherlands Academy of Arts and Sciences
Johan H. van Es
Johan H. van Es Utrecht University
Nick Barker
Nick Barker Agency for Science, Technology and Research
Alexander van Oudenaarden
Alexander van Oudenaarden University Medical Center Utrecht
Edwin Cuppen
Edwin Cuppen Utrecht University
Peter J. Peters
Peter J. Peters Maastricht University
Toshiro Sato
Toshiro Sato Keio University
Bon-Kyoung Koo
Bon-Kyoung Koo Austrian Academy of Sciences
Owen J. Sansom
Owen J. Sansom University of Glasgow
David A. Tuveson
David A. Tuveson Cold Spring Harbor Laboratory

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