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Klaus Pfizenmaier

Klaus Pfizenmaier

D-Index & Metrics

Biology and Biochemistry

D-Index
86
Citations
25920
World Ranking
2973
National Ranking
220

Overview

Klaus Pfizenmaier is affiliated with the University of Stuttgart in Germany and focuses their research primarily on medicine and immunology and microbiology. Their work spans multiple subfields including immunology, oncology, pathology and forensic medicine, neurology, and radiology, nuclear medicine and imaging.

Their research topics cover a range of areas within immunology and neurological disease, notably:

  • Multiple Sclerosis Research Studies
  • Cytokine Signaling Pathways and Interactions
  • Immune Response and Inflammation
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Monoclonal and Polyclonal Antibodies Research
  • Peptidase Inhibition and Analysis
  • Immunotherapy and Immune Responses

Pfizenmaier has authored several papers published across multiple journals. Recent articles include:

  • "Selective Targeting of TNF Receptors as a Novel Therapeutic Approach," 2020, Frontiers in Cell and Developmental Biology
  • "TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice," 2020, Cell Death and Disease
  • "OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models," 2020, Clinical Cancer Research
  • "The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation," 2021, Frontiers in Immunology
  • "Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis," 2023, Journal of Neuroinflammation

Their publications have appeared frequently in venues such as:

  • Journal of Neuroinflammation
  • Scientific Reports
  • Cancer Research
  • Frontiers in Cell and Developmental Biology
  • Cell Death and Disease

Pfizenmaier collaborates regularly with several researchers, with numerous co-authored works involving:

  • Roland E. Kontermann
  • Roman Fischer
  • Cristina Suárez Ferrer
  • Oliver Seifert
  • Fabian Richter

Best Publications

  • Tumor necrosis factor signaling.

    H Wajant;K Pfizenmaier;P Scheurich

  • THE TRANSMEMBRANE FORM OF TUMOR NECROSIS FACTOR IS THE PRIME ACTIVATING LIGAND OF THE 80 KDA TUMOR NECROSIS FACTOR RECEPTOR

    Matthias Grell;Eleni Douni;Harald Wajant;Matthias Löhden

  • PKCu is a novel, atypical member of the protein kinase C family.

    F.J. Johannes;J. Prestle;S. Eis;P. Oberhagemann

  • PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

    Gertraud Müller;Mohamed Ayoub;Peter Storz;Jörg Rennecke

  • Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses

    P Scheurich;B Thoma;U Ucer;K Pfizenmaier

  • Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway.

    Lara Marchetti;Matthias Klein;Katalin Schlett;Katalin Schlett;Klaus Pfizenmaier

  • Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2.

    Valerie Fontaine;Saddek Mohand-Said;Noelle Hanoteau;Céline Fuchs

  • Cyclophosphamide-sensitive T lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T lymphocytes

    M Rollinghoff;A Starzinski-Powitz;K Pfizenmaier;H Wagner

  • Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIβ at the Golgi complex

    Angelika Hausser;Peter Storz;Susanne Märtens;Gisela Link

  • Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma

    Sunitha Kakarla;Kevin K H Chow;Kevin K H Chow;Melinda Mata;Melinda Mata;Donald R Shaffer;Donald R Shaffer

  • Tumor necrosis factor enhances HLA-A,B,C and HLA-DR gene expression in human tumor cells.

    K Pfizenmaier;P Scheurich;C Schlüter;M Krönke

  • T-T cell interactions during cytotoxic T lymphocyte (CTL) responses: T cell derived helper factor (Interleukin 2) as a probe to analyze CTL responsiveness and thymic maturation of CTL progenitors.

    Hermann Wagner;Conny Hardt;Klaus Heeg;Klaus Pfizenmaier

  • T-cell-derived helper factor allows in vivo induction of cytotoxic T cells in nu/nu mice.

    Hermann Wagner;Conny Hardt;Klaus Heeg;Martin Röllinghoff

  • Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor.

    Manolis Pasparakis;Lena Alexopoulou;Matthias Grell;Klaus Pfizenmaier

  • Non-apoptotic Fas signaling.

    Harald Wajant;Klaus Pfizenmaier;Peter Scheurich

  • Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative.

    Harald Wajant;Dieter Moosmayer;Dieter Moosmayer;Thomas Wüest;Till Bartke

  • Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein.

    Adolf Himmler;Ingrid Maurer-Fogy;Martin Krönke;Peter Scheurich

  • Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand

    Agnes Wyzgol;Nicole Müller;Andrea Fick;Sabine Munkel

  • Regulation of secretory transport by protein kinase D–mediated phosphorylation of the ceramide transfer protein

    Tim Fugmann;Angelika Hausser;Patrik Schöffler;Simone Schmid

  • In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis.

    Sabine Küsters;Gisa Tiegs;Lena Alexopoulou;Manolis Pasparakis

Frequent Co-Authors

Roland E. Kontermann
Roland E. Kontermann University of Stuttgart
Harald Wajant
Harald Wajant University of Würzburg
Peter Scheurich
Peter Scheurich University of Stuttgart
Martin Röllinghoff
Martin Röllinghoff University of Erlangen-Nuremberg
Hermann Wagner
Hermann Wagner Technical University of Munich
Martin Krönke
Martin Krönke University of Cologne
John R. Bethea
John R. Bethea George Washington University
Andreas Herrmann
Andreas Herrmann Humboldt-Universität zu Berlin
Stephen Gottschalk
Stephen Gottschalk St. Jude Children's Research Hospital
George Kollias
George Kollias National and Kapodistrian University of Athens

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