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D-Index & Metrics

Biology and Biochemistry

D-Index
86
Citations
25785
World Ranking
2978
National Ranking
221

Overview

Harald Wajant is affiliated with the University of Würzburg in Germany. Their research primarily spans immunology, microbiology, and medicine, with substantial contributions to biochemistry, genetics, and molecular biology. Within these fields, their work focuses on several specific subfields including immunology, molecular biology, cancer research, radiology and nuclear medicine, and oncology.

Their main areas of study include T-cell and B-cell immunology, immunotherapy and immune responses, as well as immune cell function and interaction. Additional topics frequently addressed in their research encompass monoclonal and polyclonal antibodies, immune response and inflammation, NF-κB signaling pathways, and interferon-related immune responses.

Harald Wajant has coauthored extensively with a group of frequent collaborators. These include Isabell Lang, Juliane Medler, Olena Zaitseva, Kirstin Kucka, and Andreas Beilhack.

Their publications are well represented in several prominent academic journals. Notable venues where they have multiple publications include Frontiers in Immunology, Frontiers in Cell and Developmental Biology, Cell Death and Disease, Cancers, and the Proceedings of the National Academy of Sciences.

Some recent publications by Harald Wajant include:

  • Receptor Oligomerization and Its Relevance for Signaling by Receptors of the Tumor Necrosis Factor Receptor Superfamily, 2021, Frontiers in Cell and Developmental Biology
  • Tumor necrosis factor receptor family costimulation increases regulatory T-cell activation and function via NF-κB, 2020, European Journal of Immunology
  • Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells, 2020, Science Signaling
  • TNF and TNF receptors as therapeutic targets for rheumatic diseases and beyond, 2023, Nature Reviews Rheumatology
  • TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer, 2022, Cancers

Best Publications

  • Tumor necrosis factor signaling.

    H Wajant;K Pfizenmaier;P Scheurich

  • THE TRANSMEMBRANE FORM OF TUMOR NECROSIS FACTOR IS THE PRIME ACTIVATING LIGAND OF THE 80 KDA TUMOR NECROSIS FACTOR RECEPTOR

    Matthias Grell;Eleni Douni;Harald Wajant;Matthias Löhden

  • The Fas Signaling Pathway: More Than a Paradigm

    Harald Wajant

  • NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

    Sebastian Kreuz;Daniela Siegmund;Peter Scheurich;Harald Wajant

  • The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor

    Matthias Grell;Harald Wajant;Gudrun Zimmermann;Peter Scheurich

  • The CD95 receptor: apoptosis revisited.

    Marcus E. Peter;Ralph C. Budd;Julie Desbarats;Stephen M. Hedrick

  • The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.

    Harald Wajant;Frank Henkler;Peter Scheurich

  • Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF‐R1 activation by endogenous membrane‐anchored TNF

    Matthias Grell;Gudrun Zimmermann;Eva Gottfried;Chun Ming Chen;Chun Ming Chen

  • TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages.

    Harald Wajant;Daniela Siegmund

  • Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8

    Mariola Fotin-Mleczek;Frank Henkler;Dierk Samel;Monica Reichwein

  • Anti–Tumor Necrosis Factor Therapy Inhibits Pancreatic Tumor Growth and Metastasis

    Jan-Hendrik Egberts;Vera Cloosters;Andreas Noack;Bodo Schniewind

  • NFκB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP

    Sebastian Kreuz;Daniela Siegmund;Jost-Julian Rumpf;Dierk Samel

  • Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis.

    Ingo H Engels;Ania Stepczynska;Christopher Stroh;Kirsten Lauber

  • TNFR1‐induced activation of the classical NF‐κB pathway

    Harald Wajant;Peter Scheurich

  • Non-apoptotic Fas signaling.

    Harald Wajant;Klaus Pfizenmaier;Peter Scheurich

  • Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative.

    Harald Wajant;Dieter Moosmayer;Dieter Moosmayer;Thomas Wüest;Till Bartke

  • TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma.

    A Trauzold;D Siegmund;B Schniewind;B Sipos

  • The Human Tumor Necrosis Factor (TNF) Receptor-associated Factor 1 Gene (TRAF1) Is Up-regulated by Cytokines of the TNF Ligand Family and Modulates TNF-induced Activation of NF-κB and c-Jun N-terminal Kinase

    Ralph Schwenzer;Katrin Siemienski;Susanne Liptay;Gisela Schubert

  • Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand

    Agnes Wyzgol;Nicole Müller;Andrea Fick;Sabine Munkel

  • Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling.

    Harald Wajant;Peter Scheurich

Frequent Co-Authors

Peter Scheurich
Peter Scheurich University of Stuttgart
Franz Effenberger
Franz Effenberger University of Stuttgart
Klaus Pfizenmaier
Klaus Pfizenmaier University of Stuttgart
Hermann Einsele
Hermann Einsele University of Würzburg
Martin Leverkus
Martin Leverkus RWTH Aachen University
Daniela N. Männel
Daniela N. Männel University of Regensburg
Wijnand Helfrich
Wijnand Helfrich University Medical Center Groningen
Jürg Tschopp
Jürg Tschopp University of Lausanne
Michael Kracht
Michael Kracht University of Giessen
Daniela Berg
Daniela Berg University Hospital Schleswig-Holstein

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