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Immunology

D-Index
78
Citations
18965
World Ranking
1777
National Ranking
877

Overview

Linda C. Burkly is affiliated with Biogen in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and neuroscience, with a particular focus on neuroinflammation and neurodegeneration mechanisms.

Burkly has contributed to fields such as neurology, molecular biology, immunology, cancer research, and cellular and molecular neuroscience. Their work addresses topics including NF-κB signaling pathways, psoriasis treatment and pathogenesis, retinoids in leukemia and cellular processes, acute ischemic stroke management, genetic associations and epidemiology, and nuclear receptors and signaling.

The researcher has published extensively, producing notable papers such as:

  • Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism, 2020, Neuron
  • TWEAK functions with TNF and IL-17 on keratinocytes and is a potential target for psoriasis therapy, 2021, Science Immunology
  • Multi-ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke, 2022, Brain
  • Developmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration, 2021, Proceedings of the National Academy of Sciences
  • Proteomic Characterization of the Dynamics of Ischemic Stroke in Mice, 2021, Journal of Proteome Research

Their frequent co-authors include Ashley N. Nelson, Dann Huh, Rinkesh Kumar Gupta, Donald T. Gracias, and Michael Croft. The collaborative nature of these partnerships indicates an interdisciplinary approach to complex biological questions.

Burkly's research is regularly published in journals such as Scientific Reports, bioRxiv (Cold Spring Harbor Laboratory), The Journal of Immunology, Neuron, and Science Immunology.

Best Publications

  • Expression of relB is required for the development of thymic medulla and dendritic cells

    Burkly L;Hession C;Ogata L;Reilly C

  • Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates.

    Allan D. Kirk;Allan D. Kirk;Allan D. Kirk;Linda C. Burkly;D. Scott Batty;Roxanne E. Baumgartner

  • Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice: Impaired Lymphocyte Migration to Bone Marrow

    Pandelakis A. Koni;Sunil K. Joshi;Ulla-Angela Temann;Dian Olson

  • Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154

    Norma S. Kenyon;Maria Chatzipetrou;Michele Masetti;Alessandra Ranuncoli

  • TWEAK induces liver progenitor cell proliferation

    Aniela Jakubowski;Christine Ambrose;Michael Parr;John M. Lincecum

  • Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotype

    Esther Lutgens;Kitty B. J. M. Cleutjens;Sylvia Heeneman;Victor E. Koteliansky

  • Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells.

    David Lo;Linda C. Burkly;Georg Widera;Carol Cowing

  • The effect of thymus environment on T cell development and tolerance

    Philippa Marrack;David Lo;Ralph Brinster;Richard Palmiter

  • TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease.

    Linda C. Burkly;Jennifer S. Michaelson;Kyungmin Hahm;Aniela Jakubowski

  • Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.

    Norma S. Kenyon;Luis A. Fernandez;Roger Lehmann;Michele Masetti

  • T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I-E.

    Linda C. Burkly;David Lo;David Lo;Osami Kanagawa;Ralph L. Brinster

  • TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses.

    Linda C. Burkly;Jennifer S. Michaelson;Timothy S. Zheng

  • TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration

    Mahasweta Girgenrath;Shawn Weng;Christine A Kostek;Beth Browning

  • Conditional Disruption of Hedgehog Signaling Pathway Defines its Critical Role in Hair Development and Regeneration

    Li Chun Wang;Zhong-Ying Liu;Laure Gambardella;Alexandra Delacour

  • TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

    Bhanu P. Pappu;Anna Borodovsky;Timothy S. Zheng;Xuexian Yang

  • Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study.

    Noa Schwartz;Tamar Rubinstein;Linda C Burkly;Christopher E Collins;Christopher E Collins

  • Proinflammatory Effects of Tweak/Fn14 Interactions in Glomerular Mesangial Cells

    Sean Campbell;Linda C. Burkly;Hua Xin Gao;Joan W. Berman

  • Increased Fibroblast Growth Factor-Inducible 14 Expression Levels Promote Glioma Cell Invasion via Rac1 and Nuclear Factor-κB and Correlate with Poor Patient Outcome

    Nhan L. Tran;Wendy S. McDonough;Benjamin A. Savitch;Shannon P. Fortin

  • TWEAK/Fn14 interactions are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host model of systemic lupus erythematosus.

    Zeguo Zhao;Linda C. Burkly;Sean Campbell;Noa Schwartz

  • Dual role for TWEAK in angiogenic regulation.

    Aniela Jakubowski;Beth Browning;Matvey Lukashev;Irene Sizing

Frequent Co-Authors

Allan D. Kirk
Allan D. Kirk Duke University
Chaim Putterman
Chaim Putterman Albert Einstein College of Medicine
Richard A. Flavell
Richard A. Flavell Yale University
Roy R. Lobb
Roy R. Lobb Biogen (United States)
David Lo
David Lo University of California, Riverside
Ralph L. Brinster
Ralph L. Brinster University of Pennsylvania
Camillo Ricordi
Camillo Ricordi University of Miami
Jesús Egido
Jesús Egido Autonomous University of Madrid
Richard D. Palmiter
Richard D. Palmiter University of Washington
Michelle Petri
Michelle Petri Johns Hopkins University School of Medicine

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