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D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
24241
World Ranking
4274
National Ranking
315

Overview

Esther Lutgens is affiliated with Ludwig-Maximilians-Universität München in Germany. Their research primarily focuses on the study of atherosclerosis and cardiovascular diseases, covering related topics in immunology, molecular biology, and biochemistry.

The scientific work spans several interconnected fields, including Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Specific subfields of study include Immunology, Molecular Biology, Oncology, Epidemiology, and Cancer Research.

The main research topics addressed by Lutgens include:

  • Atherosclerosis and Cardiovascular Diseases
  • Immune cells in cancer
  • Cell Adhesion Molecules Research
  • Adipokines, Inflammation, and Metabolic Diseases
  • Cancer Immunotherapy and Biomarkers
  • Single-cell and spatial transcriptomics
  • Chemokine receptors and signaling

Esther Lutgens has published extensively in several scientific journals. Frequent publication venues include:

  • European Heart Journal
  • Atherosclerosis
  • Nature Cardiovascular Research
  • Circulation Research
  • Science Translational Medicine

Recent notable papers include:

  • "Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics," 2020, Circulation Research
  • "Women, lipids, and atherosclerotic cardiovascular disease: a call to action from the European Atherosclerosis Society," 2023, European Heart Journal
  • "Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans," 2020, American Journal of Clinical Nutrition
  • "Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis," 2020, Science Translational Medicine
  • "Immune Checkpoint Inhibitor Therapy Aggravates T Cell-Driven Plaque Inflammation in Atherosclerosis," 2020, JACC CardioOncology

Lutgens collaborates frequently with several researchers in related disciplines. Prominent coauthors include:

  • Christian Weber
  • Dorothee Atzler
  • Laura A. Bosmans
  • Tom Seijkens
  • Menno P.J. de Winther

The body of work by Lutgens reflects a multidisciplinary approach to studying immune mechanisms, molecular and cellular pathways involved in cardiovascular and cancer-related diseases. Their research integrates cutting-edge methods such as single-cell and spatial transcriptomics to analyze complex tissue environments.

Best Publications

  • Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.

    Peter Carmeliet;Maria Grazia Lampugnani;Lieve Moons;Ferrucio Breviario

  • Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection

    Alma Zernecke;Kiril Bidzhekov;Heidi Noels;Erdenechimeg Shagdarsuren

  • Differential Expression of Bone Matrix Regulatory Proteins in Human Atherosclerotic Plaques

    Cherida R. Dhore;Jack P.M. Cleutjens;Esther Lutgens;Kitty B.J.M. Cleutjens

  • Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis

    Yvonne Döring;Helga D. Manthey;Maik Drechsler;Dirk Lievens

  • Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotype

    Esther Lutgens;Kitty B. J. M. Cleutjens;Sylvia Heeneman;Victor E. Koteliansky

  • Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.

    Carlos Silvestre-Roig;Quinte Braster;Kanin Wichapong;Ernest Y. Lee

  • Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

    Marie A.C. Depuydt;Koen H.M. Prange;Lotte Slenders;Tiit Örd

  • Atherosclerotic Plaque Destabilization Mechanisms, Models, and Therapeutic Strategies

    Carlos Silvestre-Roig;Menno P. de Winther;Christian Weber;Mat J. Daemen

  • Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis

    Dirk Lievens;Dirk Lievens;Alma Zernecke;Tom Seijkens;Oliver Soehnlein

  • Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile

    Esther Lutgens;Esther Lutgens;Dirk Lievens;Dirk Lievens;Linda Beckers;Erwin Wijnands

  • Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.

    Tomoyoshi Yamano;Jelena Nedjic;Maria Hinterberger;Madlen Steinert

  • Macrophage MicroRNA-155 Promotes Cardiac Hypertrophy and Failure

    Stephane Heymans;Maarten F. Corsten;Wouter Verhesen;Paolo Carai

  • CD40 Ligand+ Microparticles From Human Atherosclerotic Plaques Stimulate Endothelial Proliferation and Angiogenesis: A Potential Mechanism for Intraplaque Neovascularization

    Aurélie S. Leroyer;Pierre-Emmanuel Rautou;Jean-Sébastien Silvestre;Yves Castier

  • Disruption of the Cathepsin K Gene Reduces Atherosclerosis Progression and Induces Plaque Fibrosis but Accelerates Macrophage Foam Cell Formation

    E. Lutgens;S.P.M. Lutgens;B.C.G. Faber;S. Heeneman

  • Myeloid Type I Interferon Signaling Promotes Atherosclerosis by Stimulating Macrophage Recruitment to Lesions

    Pieter Goossens;Marion J.J. Gijbels;Alma Zernecke;Wouter Eijgelaar

  • Atherosclerosis: the interplay between lipids and immune cells

    Frank Schaftenaar;Vanessa Frodermann;Johan Kuiper;Esther Lutgens

  • Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis.

    Pei-Yu Chen;Lingfeng Qin;Guangxin Li;Guangxin Li;Zheng Wang

  • Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes

    Marc Tjwa;Lola Bellido-Martin;Yuan Lin;Esther Lutgens

  • Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes

    Oliver Soehnlein;Oliver Soehnlein;Oliver Soehnlein;Maik Drechsler;Maik Drechsler;Yvonne Döring;Yvonne Döring;Dirk Lievens;Dirk Lievens

  • The atherogenic effect of excess methionine intake

    Aron M. Troen;Esther Lutgens;Donald E. Smith;Irwin H. Rosenberg

Frequent Co-Authors

Christian Weber
Christian Weber Ludwig-Maximilians-Universität München
Menno P.J. de Winther
Menno P.J. de Winther University of Amsterdam
Marion J.J. Gijbels
Marion J.J. Gijbels Maastricht University
Mat J.A.P. Daemen
Mat J.A.P. Daemen University of Amsterdam
Oliver Soehnlein
Oliver Soehnlein University of Münster
Erik A.L. Biessen
Erik A.L. Biessen Maastricht University
Louis Boon
Louis Boon University of Amsterdam
Mihai G. Netea
Mihai G. Netea Radboud University
Johan W. M. Heemskerk
Johan W. M. Heemskerk Maastricht University
Alma Zernecke
Alma Zernecke University of Würzburg

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