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Johan W. M. Heemskerk

Johan W. M. Heemskerk

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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
86
Citations
24723
World Ranking
2995
National Ranking
77

Medicine

D-Index
86
Citations
25336
World Ranking
14204
National Ranking
541

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award

Overview

Johan W. M. Heemskerk is affiliated with Maastricht University in the Netherlands and focuses research primarily within the field of medicine, with a particular concentration on hematology.

The researcher's work spans several subfields, including hematology, cardiology and cardiovascular medicine, pulmonary and respiratory medicine, molecular biology, and immunology. Their publications address core topics related to platelet disorders and treatments, antiplatelet therapy and cardiovascular diseases, blood coagulation and thrombosis mechanisms, blood properties and coagulation, cell adhesion molecules research, blood groups and transfusion, and venous thromboembolism diagnosis and management.

Among recent publications authored or co-authored by Heemskerk are the following papers:

  • Assessment of a complete and classified platelet proteome from genome-wide transcripts of human platelets and megakaryocytes covering platelet functions, 2021, Scientific Reports
  • Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease, 2021, Nature Communications
  • Platelet Activation Mechanisms and Consequences of Immune Thrombocytopenia, 2021, Cells
  • Platelet GPVI (Glycoprotein VI) and Thrombotic Complications in the Venous System, 2021, Arteriosclerosis Thrombosis and Vascular Biology
  • Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity, 2020, Platelets

Frequent co-authors contributing alongside Johan W. M. Heemskerk include:

  • Marijke J. E. Kuijpers
  • Albert Sickmann
  • Bibian M. E. Tullemans
  • Frauke Swieringa
  • Mark Roest

Publications by Heemskerk have appeared predominantly in a set of specialized journals, reflecting a focus on molecular and vascular biology and hematological research:

  • International Journal of Molecular Sciences (14 publications)
  • Scientific Reports (6 publications)
  • Arteriosclerosis Thrombosis and Vascular Biology (6 publications)
  • Blood Advances (6 publications)
  • Journal of Thrombosis and Haemostasis (6 publications)

The breadth of Heemskerk's study includes extensive investigations into platelet functions at molecular and cellular levels, emphasizing pathways and mechanisms underpinning coagulation and thrombosis. The research integrates molecular biology techniques with clinical relevance to cardiovascular and hematologic disorders.

Best Publications

  • NEW FUNDAMENTALS IN HEMOSTASIS

    Henri H. Versteeg;Johan W. M. Heemskerk;Marcel Levi;Pieter H. Reitsma

  • Platelet biology and functions: new concepts and clinical perspectives.

    Paola E. J. van der Meijden;Johan W. M. Heemskerk

  • Platelet activation and blood coagulation.

    Johan W. M. Heemskerk;Edouard M. Bevers;Theo Lindhout

  • Glycoprotein VI but not α2β1 integrin is essential for platelet interaction with collagen

    Bernhard Nieswandt;Cord Brakebusch;Wolfgang Bergmeier;Valerie Schulte

  • Platelet-based coagulation: different populations, different functions

    J. W. M. Heemskerk;N. J. A. Mattheij;J. M. E. M. Cosemans

  • Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis

    Dirk Lievens;Dirk Lievens;Alma Zernecke;Tom Seijkens;Oliver Soehnlein

  • Nebivolol: a third-generation beta-blocker that augments vascular nitric oxide release: endothelial beta(2)-adrenergic receptor-mediated nitric oxide production.

    M.A.W. Broeders;P.A.F.M. Doevendans;B.C.A.M. Bekkers;R.J.P. Bronsaer

  • Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

    Erik Westein;Andries D. van der Meer;Marijke J. E. Kuijpers;Jean-Philippe Frimat

  • Platelet Inhibition by Insulin Is Absent in Type 2 Diabetes Mellitus

    Irlando Andrade Ferreira;Astrid I.M. Mocking;Marion A.H. Feijge;Gertie Gorter

  • The quercetin paradox.

    Agnes W. Boots;Hui Li;Roel P.F. Schins;Rodger Duffin

  • Factor Xa induces cytokine production and expression of adhesion molecules by human umbilical vein endothelial cells.

    N. H. M. Senden;T. M. A. A. Jeunhomme;J. W. M. Heemskerk;R. Wagenvoord

  • Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood

    Pia R.-M. Siljander;Imke C. A. Munnix;Peter A. Smethurst;Hans Deckmyn

  • Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1.

    Margitta Elvers;David Stegner;Ina Hagedorn;Christoph Kleinschnitz

  • Dual role of collagen in factor XII-dependent thrombus formation

    Paola E. J. van der Meijden;Imke C. A. Munnix;Jocelyn M. Auger;José W. P. Govers-Riemslag

  • Identification of platelet function defects by multi-parameter assessment of thrombus formation

    Susanne M de Witt;Frauke Swieringa;Rachel Cavill;Moniek M E Lamers

  • Collagen but not fibrinogen surfaces induce bleb formation, exposure of phosphatidylserine, and procoagulant activity of adherent platelets: evidence for regulation by protein tyrosine kinase-dependent Ca2+ responses.

    Johan W.M. Heemskerk;Wim M.J. Vuist;Marion A.H. Feijge;Chris P.M. Reutelingsperger

  • Segregation of Platelet Aggregatory and Procoagulant Microdomains in Thrombus Formation Regulation by Transient Integrin Activation

    Imke C.A. Munnix;Marijke J.E. Kuijpers;Jocelyn Auger;Christella M.L.G.D. Thomassen

  • PKCα regulates platelet granule secretion and thrombus formation in mice

    Olga Konopatskaya;Karen Gilio;Matthew T. Harper;Yan Zhao

  • Initiating and potentiating role of platelets in tissue factor-induced thrombin generation in the presence of plasma: subject-dependent variation in thrombogram characteristics.

    K. Vanschoonbeek;M. A. H. Feijge;R. J. W. Van Kampen;H. Kenis

  • Optical and Magnetic Resonance Imaging of Cell Death and Platelet Activation Using Annexin A5-Functionalized Quantum Dots

    Prinzen L;Miserus Rj;Dirksen A;Hackeng Tm

Frequent Co-Authors

Stewart O. Sage
Stewart O. Sage University of Cambridge
Steve P. Watson
Steve P. Watson University of Birmingham
Esther Lutgens
Esther Lutgens Ludwig-Maximilians-Universität München
Bernhard Nieswandt
Bernhard Nieswandt University of Würzburg
Tilman M. Hackeng
Tilman M. Hackeng Maastricht University
Richard W. Farndale
Richard W. Farndale University of Cambridge
Chris P. M. Reutelingsperger
Chris P. M. Reutelingsperger Maastricht University
Christian Weber
Christian Weber Ludwig-Maximilians-Universität München

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