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D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
15957
World Ranking
6053
National Ranking
156

Overview

Tilman M. Hackeng is affiliated with Maastricht University in the Netherlands. Their main field of study is Medicine, with a focus on Hematology, Molecular Biology, Nutrition and Dietetics, Immunology, and Internal Medicine.

Their research covers a range of topics related to blood and coagulation disorders. Main topics of their work include:

  • Blood Coagulation and Thrombosis Mechanisms
  • Platelet Disorders and Treatments
  • Venous Thromboembolism Diagnosis and Management
  • Hemophilia Treatment and Research
  • Atrial Fibrillation Management and Outcomes
  • Vitamin K Research Studies
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema

They have published extensively in journals with a strong focus on thrombosis and hematology, frequently contributing to:

  • Journal of Thrombosis and Haemostasis
  • Research and Practice in Thrombosis and Haemostasis
  • Blood
  • Thrombosis Research
  • Thrombosis and Haemostasis

Their recent influential papers include:

  • Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion, 2020, Circulation
  • Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019, 2020, Clinical Infectious Diseases
  • Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis, 2020, Science Translational Medicine
  • Chemokines and galectins form heterodimers to modulate inflammation, 2020, EMBO Reports
  • Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy, 2022, Nature Communications

Frequent co-authors of Tilman M. Hackeng include:

  • Stella Thomassen
  • Kanin Wichapong
  • Ingrid Dijkgraaf
  • Hans Ippel
  • Dennis Suylen

The scope of their work reflects a multidisciplinary approach, intersecting fields such as molecular biology and nutrition with a clinical focus on thrombosis and coagulation. Their research spans foundational mechanisms of blood coagulation to clinical implications in conditions like atrial fibrillation and hemophilia.

Best Publications

  • Protein synthesis by native chemical ligation: Expanded scope by using straightforward methodology

    Tilman M. Hackeng;John H. Griffin;Philip E. Dawson

  • Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C, or protein S: an explanation for their pathogenic mechanism?

    J. D. Oosting;R. H. W. M. Derksen;I. W. G. Bobbink;T. M. Hackeng

  • Nucleophilic Catalysis of Oxime Ligation

    Anouk Dirksen;Tilman M. Hackeng;Philip E. Dawson

  • Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice.

    Rory R Koenen;Philipp von Hundelshausen;Irina V Nesmelova;Alma Zernecke

  • Nucleophilic catalysis of hydrazone formation and transimination: implications for dynamic covalent chemistry.

    Anouk Dirksen;Sjoerd Dirksen;Tilman M Hackeng;Philip E Dawson

  • Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium

    Philipp von Hundelshausen;Rory R. Koenen;Markus Sack;Sebastian F. Mause

  • Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.

    Carlos Silvestre-Roig;Quinte Braster;Kanin Wichapong;Ernest Y. Lee

  • Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor

    Tilman M. Hackeng;Kristin M. Seré;Guido Tans;Jan Rosing

  • Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification

    L. J. Schurgers;H. M. H. Spronk;J. N. Skepper;T. M. Hackeng

  • Tumor cells secrete galectin-1 to enhance endothelial cell activity.

    Victor L. Thijssen;Batya Barkan;Hiroki Shoji;Ingrid M. Aries

  • Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury.

    Jochen Grommes;Jean-Eric Alard;Maik Drechsler;Sarawuth Wantha

  • Human protein S inhibits prothrombinase complex activity on endothelial cells and platelets via direct interactions with factors Va and Xa.

    T. M. Hackeng;C. Van't Veer;J. C. M. Meijers;B. N. Bouma

  • The Circulating Inactive Form of Matrix Gla Protein (ucMGP) as a Biomarker for Cardiovascular Calcification

    Ellen C.M. Cranenburg;Cees Vermeer;Ralf Koos;Marie-Louise Boumans

  • Early Atherosclerosis Exhibits an Enhanced Procoagulant State

    Julian Ilcheff Borissoff;Sylvia Heeneman;Evren Kilinç;Peter Kaššák

  • Dendrimers and magnetic resonance imaging

    S. Langereis;A. Dirksen;T.M. Hackeng;M.H.P. van Genderen

  • A factor IX-deficient mouse model for hemophilia B gene therapy

    Lili Wang;Monica Zoppè;Tilman M. Hackeng;John H. Griffin

  • Vascular calcification: the price to pay for anticoagulation therapy with vitamin K-antagonists.

    Martijn L. L. Chatrou;Kristien Winckers;Tilman M. Hackeng;Chris P. M. Reutelingsperger

  • Optical and Magnetic Resonance Imaging of Cell Death and Platelet Activation Using Annexin A5-Functionalized Quantum Dots

    Prinzen L;Miserus Rj;Dirksen A;Hackeng Tm

  • Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases

    Rory R. Koenen;Jessica Pruessmeyer;Oliver Soehnlein;Line Fraemohs

  • Neutrophil-Derived Cathelicidin Promotes Adhesion of Classical Monocytes

    Sarawuth Wantha;Jean-Eric Alard;Remco T.A. Megens;Anne M. van der Does

Frequent Co-Authors

Christian Weber
Christian Weber Ludwig-Maximilians-Universität München
Jan Rosing
Jan Rosing Maastricht University
Oliver Soehnlein
Oliver Soehnlein University of Münster
John H. Griffin
John H. Griffin Scripps Research Institute
Guido Tans
Guido Tans Maastricht University
Esther Lutgens
Esther Lutgens Ludwig-Maximilians-Universität München
Philip E. Dawson
Philip E. Dawson Scripps Research Institute
Leon J. Schurgers
Leon J. Schurgers Maastricht University
José A. Fernández
José A. Fernández Scripps Research Institute
Bonno N. Bouma
Bonno N. Bouma Scripps Research Institute

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