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Bruno O. Villoutreix

Bruno O. Villoutreix

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
13217
World Ranking
9776
National Ranking
348

Overview

Bruno O. Villoutreix is affiliated with Université Paris Cité in France. Their research spans multiple domains within medicine and biochemistry, genetics, and molecular biology.

Their work includes significant contributions to the fields of molecular biology, computational theory and mathematics, infectious diseases, immunology, and pharmacology. These areas align with their focus on computational drug discovery methods, SARS-CoV-2 and COVID-19 research, protein structure and dynamics, microbial natural products and biosynthesis, blood coagulation and thrombosis mechanisms, pharmacological receptor mechanisms and effects, and signaling pathways in disease.

Frequent coauthors in their research include:

  • Natesh Singh
  • Abdel-Majid Khatib
  • Ludovic Chaput
  • Maria A. Miteva
  • Alireza R. Rezaie

Villoutreix has published extensively in several scientific journals. Among the main venues where their work appears are:

  • Frontiers in Drug Discovery
  • International Journal of Molecular Sciences
  • Drug Discovery Today
  • Thrombosis and Haemostasis
  • The FASEB Journal

Notable recent publications include:

  • "Drug discovery and development: introduction to the general public and patient groups" (2023), Frontiers in Drug Discovery
  • "Virtual screening web servers: designing chemical probes and drug candidates in the cyberspace" (2020), Briefings in Bioinformatics
  • "In Silico Investigation of the New UK (B.1.1.7) and South African (501Y.V2) SARS-CoV-2 Variants with a Focus at the ACE2-Spike RBD Interface" (2021), International Journal of Molecular Sciences
  • "Anti-Factor B Antibodies and Acute Postinfectious GN in Children" (2020), Journal of the American Society of Nephrology
  • "Structure-based drug repositioning over the human TMPRSS2 protease domain: search for chemical probes able to repress SARS-CoV-2 Spike protein cleavages" (2020), European Journal of Pharmaceutical Sciences

The research topics covered in these publications address various aspects, including drug discovery processes, virtual screening methodologies for drug candidates, computational analyses of SARS-CoV-2 variants, immunological studies in pediatric nephrology, and structure-based drug repositioning targeting viral proteins.

Best Publications

  • Regulation of Blood Coagulation by the Protein C Anticoagulant Pathway: Novel Insights Into Structure-Function Relationships and Molecular Recognition

    Björn Dahlbäck;Bruno O Villoutreix

  • The anticoagulant protein C pathway

    Björn Dahlbäck;Bruno O Villoutreix

  • Druggable pockets and binding site centric chemical space: a paradigm shift in drug discovery

    Stéphanie Pérot;Olivier Sperandio;Maria A. Miteva;Anne-Claude Camproux

  • FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects

    David Lagorce;Olivier Sperandio;Hervé Galons;Maria A Miteva

  • FAF-Drugs3: a web server for compound property calculation and chemical library design

    David Lagorce;Olivier Sperandio;Jonathan B. Baell;Maria A. Miteva

  • Toward in silico structure-based ADMET prediction in drug discovery.

    Gautier Moroy;Virginie Y. Martiny;Philippe Vayer;Bruno O. Villoutreix

  • Complement inhibitor C4b-binding protein: friend or foe in the innate immune system?

    Anna M. Blom;Bruno O. Villoutreix;Björn Dahlbäck

  • FAF-Drugs4: free ADME-tox filtering computations for chemical biology and early stages drug discovery.

    David Lagorce;Lina Bouslama;Jerome Becot;Maria A Miteva

  • Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome.

    Frank Bienaime;Frank Bienaime;Marie-Agnes Dragon-Durey;Catherine H. Regnier;Catherine H. Regnier;Sara C. Nilsson

  • Rationalizing the chemical space of protein-protein interaction inhibitors.

    Olivier Sperandio;Christelle H. Reynès;Anne-Claude Camproux;Bruno O. Villoutreix

  • MTiOpenScreen: a web server for structure-based virtual screening

    Céline M. Labbé;Julien Rey;David Lagorce;David Lagorce;Marek Vavruša;Marek Vavruša

  • 3-Dimensional structure of membrane-bound coagulation factor VIII: Modeling of the factor VIII heterodimer within a 3-dimensional density map derived by electron crystallography

    Svetla Stoilova-McPhie;Bruno O. Villoutreix;Koen Mertens;Geoffrey Kemball-Cook

  • A Novel Interaction of Outer Membrane Protein A with C4b Binding Protein Mediates Serum Resistance of Escherichia coli K1.

    Nemani V. Prasadarao;Anna M. Blom;Bruno O. Villoutreix;Linette C. Linsangan

  • Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitors

    David Lagorce;Dominique Douguet;Maria A. Miteva;Bruno O. Villoutreix

  • Structure-Based Virtual Ligand Screening: Recent Success Stories

    Bruno O. Villoutreix;Richard Eudes;Maria A. Miteva

  • FAF-Drugs: free ADME/tox filtering of compound collections

    Maria A. Miteva;Stephanie Violas;Matthieu Montes;David Gomez

  • MS-DOCK: accurate multiple conformation generator and rigid docking protocol for multi-step virtual ligand screening.

    Nicolas Sauton;David Lagorce;Bruno O Villoutreix;Maria A Miteva

  • Frog: a FRee Online druG 3D conformation generator

    T. Bohme Leite;D. Gomes;Maria A. Miteva;Jacques Chomilier

  • A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells.

    Annette Säfholm;Karin Leandersson;Janna Dejmek;Christian Kamp Nielsen

  • A Cluster of Positively Charged Amino Acids in the C4BP α-Chain Is Crucial for C4b Binding and Factor I Cofactor Function

    Anna M. Blom;Joanna Webb;Bruno O. Villoutreix;Björn Dahlbäck

Frequent Co-Authors

Björn Dahlbäck
Björn Dahlbäck Lund University
Anna M. Blom
Anna M. Blom Lund University
Alireza R. Rezaie
Alireza R. Rezaie Oklahoma Medical Research Foundation
Leendert A. Trouw
Leendert A. Trouw Leiden University Medical Center
Johan Stenflo
Johan Stenflo Lund University
John H. Griffin
John H. Griffin Scripps Research Institute
Bernard Ducommun
Bernard Ducommun Federal University of Toulouse Midi-Pyrénées
Marion Leboyer
Marion Leboyer Paris-Est Créteil University

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