World's Best Scientists 2026 revealed!
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Chemistry
Mexico
2025
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Engineering and Technology
Mexico
2025

D-Index & Metrics

Engineering and Technology

D-Index
58
Citations
11203
World Ranking
2527
National Ranking
4

Chemistry

D-Index
65
Citations
14276
World Ranking
7708
National Ranking
5

Research.com Recognitions

  • 2025 - Research.com Chemistry in Mexico Leader Award
  • 2025 - Research.com Engineering and Technology in Mexico Leader Award

Overview

José L. Medina-Franco is affiliated with the National Autonomous University of Mexico. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Computer Science. Within these broad areas, their work focuses on several subfields including Molecular Biology, Computational Theory and Mathematics, Pharmacology, Organic Chemistry, and Materials Chemistry.

The scientist's main research topics include Computational Drug Discovery Methods, Microbial Natural Products and Biosynthesis, Plant Biochemistry and Biosynthesis, Genetics, Bioinformatics, and Biomedical Research, Metabolomics and Mass Spectrometry Studies, Epigenetics and DNA Methylation, and Bioinformatics and Genomic Networks.

Recent publications by José L. Medina-Franco illustrate their involvement in various aspects of drug design, natural product profiling, and computational approaches. These papers include:

  • Editorial: In silico Methods for Drug Design and Discovery (2020, Frontiers in Chemistry)
  • In Silico ADME/Tox Profiling of Natural Products: A Focus on BIOFACQUIM (2020, ACS Omega)
  • A critical overview of computational approaches employed for COVID-19 drug discovery (2021, Chemical Society Reviews)
  • Natural product drug discovery in the artificial intelligence era (2021, Chemical Science)
  • Extended connectivity interaction features: improving binding affinity prediction through chemical description (2020, Bioinformatics)

The scientist frequently collaborates with several coauthors, including Edgar López-López, Fernanda I. Saldívar-González, Ana L. Chávez-Hernández, Norberto Sánchez-Cruz, and K. Eurídice Juárez-Mercado.

Their research is often published in recognized venues such as Molecular Informatics, Biomolecules, Journal of Chemical Information and Modeling, ACS Omega, and Journal of Cheminformatics.

Best Publications

  • Shifting from the single to the multitarget paradigm in drug discovery.

    José L. Medina-Franco;Marc A. Giulianotti;Gregory S. Welmaker;Richard A. Houghten

  • Recognizing Pitfalls in Virtual Screening: A Critical Review

    Thomas Scior;Andreas Bender;Gary Tresadern;José L. Medina-Franco

  • Editorial: In silico Methods for Drug Design and Discovery.

    Simone Brogi;Teodorico Castro Ramalho;Kamil Kuca;José L. Medina-Franco

  • How to recognize and workaround pitfalls in QSAR studies: a critical review.

    T. Scior;J. L. Medina-Franco;Q.-T. Do;K. Martinez-Mayorga

  • Natural product drug discovery in the artificial intelligence era

    Unknown

  • Nanaomycin A Selectively Inhibits DNMT3B and Reactivates Silenced Tumor Suppressor Genes in Human Cancer Cells

    Dirk Kuck;Thomas Caulfield;Frank Lyko;Jose Luis Medina-Franco

  • Activity cliffs in drug discovery: Dr Jekyll or Mr Hyde?

    Maykel Cruz-Monteagudo;José L. Medina-Franco;Yunierkis Pérez-Castillo;Orazio Nicolotti

  • In Silico ADME/Tox Profiling of Natural Products: A Focus on BIOFACQUIM.

    Noemi Angeles Durán-Iturbide;Bárbara I Díaz-Eufracio;José L Medina-Franco

  • Synthesis and Biochemical Evaluation of Δ2-Isoxazoline Derivatives as DNA Methyltransferase 1 Inhibitors

    Sabrina Castellano;Dirk Kuck;Monica Viviano;Jakyung Yoo

  • Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation.

    Dirk Kuck;Narender Singh;Frank Lyko;Jose L. Medina-Franco

  • Integrating virtual screening and combinatorial chemistry for accelerated drug discovery.

    Fabian Lopez-Vallejo;Thomas Caulfield;Karina Martinez-Mayorga;Marc A. Giulianotti

  • A critical overview of computational approaches employed for COVID-19 drug discovery.

    Eugene N Muratov;Rommie Amaro;Carolina H Andrade;Nathan Brown

  • Visualization of the Chemical Space in Drug Discovery

    Jose L. Medina-Franco;Karina Martinez-Mayorga;Marc A. Giulianotti;Richard A. Houghten

  • Characterization of activity landscapes using 2D and 3D similarity methods: consensus activity cliffs.

    Jose L Medina-Franco;Karina Martínez-Mayorga;Andreas Bender;Ray M Marín

  • Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries small molecule repository.

    Narender Singh;Rajarshi Guha;Marc A Giulianotti;Clemencia Pinilla

  • The many roles of molecular complexity in drug discovery.

    Oscar Méndez-Lucio;José L. Medina-Franco

  • Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach.

    Jose L. Medina-Franco;Fabian López-Vallejo;Dirk Kuck;Frank Lyko

  • Expanding the medicinally relevant chemical space with compound libraries.

    Fabian López-Vallejo;Marc A. Giulianotti;Richard A. Houghten;José L. Medina-Franco

  • Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP–1B: In vitro, in silico, and in vivo approaches

    Juan José Ramírez-Espinosa;Maria Yolanda Rios;Sugey López-Martínez;Fabian López-Vallejo

  • DataWarrior: an evaluation of the open-source drug discovery tool

    Edgar López-López;J Jesús Naveja;José L Medina-Franco

  • Antidiabetic activity of N-(6-substituted-1,3-benzothiazol-2-yl)benzenesulfonamides

    Hermenegilda Moreno-Díaz;Rafael Villalobos-Molina;Rolffy Ortiz-Andrade;Daniel Díaz-Coutiño

  • Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.

    Richard A. Houghten;Clemencia Pinilla;Marc A. Giulianotti;Jon R. Appel

  • A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: Quercetin as a potential antidiabetic agent acting via 11β-Hydroxysteroid dehydrogenase type 1 inhibition

    Mariana Torres-Piedra;Rolffy Ortiz-Andrade;Rafael Villalobos-Molina;Narender Singh

Frequent Co-Authors

Richard A. Houghten
Richard A. Houghten Florida International University
Clemencia Pinilla
Clemencia Pinilla Florida International University
Jürgen Bajorath
Jürgen Bajorath University of Bonn
Andreas Bender
Andreas Bender University of Cambridge
Frank Lyko
Frank Lyko German Cancer Research Center
Fernanda Borges
Fernanda Borges University of Porto
Larry A. Sklar
Larry A. Sklar University of New Mexico
Nicholas H. Oberlies
Nicholas H. Oberlies University of North Carolina at Greensboro
David A. Winkler
David A. Winkler La Trobe University
Alexander Tropsha
Alexander Tropsha University of North Carolina at Chapel Hill

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