Richard A. Houghten

Research.com Recognitions

• 2013 - Fellow of the American Association for the Advancement of Science (AAAS)
• 2012 - Fellow, National Academy of Inventors

Overview

Best Publications

• General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids

  Richard A. Houghten

  2789
  Citations

• Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

  Richard A. Houghten;Clemencia Pinilla;Sylvie E. Blondelle;Jon R. Appel

  1782
  Citations

• The structure of an antigenic determinant in a protein

  Ian A. Wilson;Henry L. Niman;Richard A. Houghten;Andrew R. Cherenson

  1333
  Citations

• Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence

  James L. Bittle;Richard A. Houghten;Hannah Alexander;Thomas M. Shinnick

  1211
  Citations

• The value of antimicrobial peptides in the age of resistance

  Maria Magana;Muthuirulan Pushpanathan;Ana L Santos;Leon Leanse

  1042
  Citations

• An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes.

  Hidemi Takahashi;Joseph Cohen;Anne Hosmalin;Kemp B. Cease

  591
  Citations

• Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.

  Henry L. Niman;Richard A. Houghten;Leslie E. Walker;Ralph A. Reisfeld

  563
  Citations

• The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein.

  John A. Tainer;Elizabeth D. Getzoff;Hannah Alexander;Richard A. Houghten

  560
  Citations

• Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.

  Aaron D. Schimmer;Kate Welsh;Clemencia Pinilla;Zhiliang Wang

  544
  Citations

• Shifting from the single to the multitarget paradigm in drug discovery.

  José L. Medina-Franco;Marc A. Giulianotti;Gregory S. Welmaker;Richard A. Houghten

  538
  Citations

• Design of model amphipathic peptides having potent antimicrobial activities

  Sylvie E. Blondelle;Richard A. Houghten

  522
  Citations

• A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform.

  D Peretz;R A Williamson;Y Matsunaga;H Serban

  439
  Citations

• Hemolytic and antimicrobial activities of the twenty-four individual omission analogues of melittin.

  Sylvie E. Blondelle;Richard A. Houghten

  379
  Citations

• The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides.

  Houghten Ra;Appel;Blondelle Se;Cuervo Jh

  361
  Citations

• "Libraries from libraries": chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity

  John M. Ostresh;Gregory M. Husar;Sylvie E. Blondelle;Barbara Dorner

  353
  Citations

• Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule

  Michael F. Good;David Pombo;Isabella A. Quakyi;Eleanor M. Riley

  346
  Citations

• The immunodominant site of a synthetic immunogen has a conformational preference in water for a type-II reverse turn

  Dyson Hj;Cross Kj;Houghten Ra;Wilson Ia

  322
  Citations

• Mapping the Prion Protein Using Recombinant Antibodies

  R. Anthony Williamson;David Peretz;Clemencia Pinilla;Hadyn Ball

  317
  Citations

• Mixture-based synthetic combinatorial libraries.

  Richard A. Houghten;Clemencia Pinilla;Jon R. Appel;Sylvie E. Blondelle

  298
  Citations

• Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease.

  Bernhard Hemmer;Bruno Gran;Yingdong Zhao;Adriana Marques

  288
  Citations