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Medicine

D-Index
127
Citations
70424
World Ranking
2801
National Ranking
1563

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

C. Kent Osborne is affiliated with Baylor College of Medicine in the United States and specializes in research primarily within the fields of medicine and biochemistry, genetics, and molecular biology. Their work focuses notably on oncology, radiology, nuclear medicine and imaging, pulmonary and respiratory medicine, genetics, and molecular biology as subfields of study.

The scientist's research predominantly covers topics related to HER2/EGFR in cancer research, monoclonal and polyclonal antibodies research, advanced breast cancer therapies, cancer genomics and diagnostics, cancer immunotherapy and biomarkers, chronic myeloid leukemia treatments, and chronic lymphocytic leukemia research.

Their recent publications include:

  • Abstract 1911: HER2 L755S mutation is associated with acquired resistance to lapatinib and neratinib, and confers cross-resistance to tucatinib in HER2-positive breast cancer models (2020, Cancer Research)
  • Abstract PD3-09: HER2 L755S mutation is acquired upon resistance to lapatinib and neratinib and confers cross-resistance to tucatinib and trastuzumab in HER2-positive breast cancer cell models (2021, Cancer Research)
  • Abstract PD8-03: A FOXA1/FRA1-centered transcriptional axis regulates interferon signaling in high FOXA1-associated endocrine-resistant and metastatic breast cancer (2021, Cancer Research)
  • Abstract 1077: Acquired neratinib resistance is associated with acquisition of HER2 and PIK3CA mutations and can be overcome using potent drug combinations in HER2-positive breast cancer models (2021, Cancer Research)
  • Abstract SP139: HER2 targeted therapy: Determinants of response and mechanisms of resistance (2021, Cancer Research)

Frequent co-authors of C. Kent Osborne include:

  • Mothaffar F. Rimawi
  • Rachel Schiff
  • Jamunarani Veeraraghavan
  • Sarmistha Nanda
  • Martin J. Shea

Key publication venues where their work appears most often are:

  • Cancer Research
  • Journal of Clinical Oncology
  • Clinical Cancer Research
  • ESMO Open
  • bioRxiv (Cold Spring Harbor Laboratory)

C. Kent Osborne has been recognized as a member of the Association of American Physicians. Their research contributions offer insights into molecular mechanisms of breast cancer resistance and targeted therapies, emphasizing the development of therapeutic strategies in oncology.

Best Publications

  • American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer

    M. Elizabeth H. Hammond;Daniel F Hayes;Mitch Dowsett;D Craig Allred

  • Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013

    A Goldhirsch;E P Winer;A S Coates;R D Gelber

  • Estrogen Receptor Status by Immunohistochemistry Is Superior to the Ligand-Binding Assay for Predicting Response to Adjuvant Endocrine Therapy in Breast Cancer

    Jennet M. Harvey;Gary M. Clark;C. Kent Osborne;D. Craig Allred

  • Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

    Xiaoxian Li;Michael T. Lewis;Jian Huang;Carolina Gutierrez

  • Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial

    Kathy S Albain;William E Barlow;Steven Shak;Gabriel N Hortobagyi

  • Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer.

    Jiang Shou;Suleiman Massarweh;C. Kent Osborne;Alan E. Wakeling

  • Mechanisms of Endocrine Resistance in Breast Cancer

    C. Kent Osborne;Rachel Schiff

  • Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer

    Matthew D. Burstein;Anna Tsimelzon;Graham M. Poage;Kyle R. Covington

  • Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer

    Jenny C. Chang;Eric C. Wooten;Anna Tsimelzon;Susan G. Hilsenbeck

  • Role of the Estrogen Receptor Coactivator AIB1 (SRC-3) and HER-2/neu in Tamoxifen Resistance in Breast Cancer

    C. Kent Osborne;Valerie Bardou;Torsten A. Hopp;Gary C. Chamness

  • Treatment of HER2-positive breast cancer: current status and future perspectives

    Carlos L. Arteaga;Mark X. Sliwkowski;C. Kent Osborne;Edith A. Perez

  • Progesterone Receptor Status Significantly Improves Outcome Prediction Over Estrogen Receptor Status Alone for Adjuvant Endocrine Therapy in Two Large Breast Cancer Databases

    Valerie Jeanne Bardou;Grazia Arpino;Richard M. Elledge;C. Kent Osborne

  • Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu.

    Christopher C. Benz;Gary K. Scott;Jay C. Sarup;Randolph M. Johnson

  • The value of estrogen and progesterone receptors in the treatment of breast cancer

    C. Kent Osborne;Michael G. Yochmowitz;William A. Knight;William L. McGuire

  • Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer

    D. C. Allred;G. M. Clark;R. Elledge;S. A. W. Fuqua

  • Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes

    Robert M. Lavinsky;Kristen Jepsen;Thorsten Heinzel;Joseph Torchia

  • Crosstalk between the Estrogen Receptor and the HER Tyrosine Kinase Receptor Family: Molecular Mechanism and Clinical Implications for Endocrine Therapy Resistance

    Grazia Arpino;Lisa Wiechmann;C. Kent Osborne;Rachel Schiff

  • Biology of Progesterone Receptor Loss in Breast Cancer and Its Implications for Endocrine Therapy

    Xiaojiang Cui;Rachel Schiff;Grazia Arpino;C. Kent Osborne

  • Tumor biologic factors and breast cancer prognosis among white, Hispanic, and black women in the United States.

    Richard M. Elledge;Gary M. Clark;Gary C. Chamness;C. Kent Osborne

  • Molecular Changes in Tamoxifen-Resistant Breast Cancer: Relationship Between Estrogen Receptor, HER-2, and p38 Mitogen-Activated Protein Kinase

    M. Carolina Gutierrez;Simone Detre;Stephen Johnston;Syed K. Mohsin

Frequent Co-Authors

Rachel Schiff
Rachel Schiff Baylor College of Medicine
Susan G. Hilsenbeck
Susan G. Hilsenbeck Baylor College of Medicine
D. Craig Allred
D. Craig Allred The University of Texas Health Science Center at San Antonio
Suzanne A. W. Fuqua
Suzanne A. W. Fuqua Baylor College of Medicine
Chad J. Creighton
Chad J. Creighton Baylor College of Medicine
Daniel F. Hayes
Daniel F. Hayes University of Michigan–Ann Arbor
Gary M. Clark
Gary M. Clark The University of Texas Health Science Center at San Antonio
Jenny C. Chang
Jenny C. Chang Houston Methodist
Chad A. Shaw
Chad A. Shaw Baylor College of Medicine
Mitch Dowsett
Mitch Dowsett Breast Cancer Research Foundation

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