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Biology and Biochemistry

D-Index
66
Citations
18373
World Ranking
8552
National Ranking
3843

Overview

Roland K. Strong is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research spans several intersecting fields, primarily within Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. These main fields are further specified through subfields including Molecular Biology, Immunology, Infectious Diseases, Oncology, and Radiology, Nuclear Medicine and Imaging.

Their work covers a variety of topics including Immunotherapy and Immune Responses, vaccines and immunoinformatics approaches, T-cell and B-cell Immunology, SARS-CoV-2 and COVID-19 Research, SARS-CoV-2 detection and testing, Peptidase Inhibition and Analysis, and Monoclonal and Polyclonal Antibodies Research.

Recent publications reflect a focus on viral immunology, peptide research, and assay evaluation. Notable papers include:

  • Evaluation of Cell-Based and Surrogate SARS-CoV-2 Neutralization Assays, 2021, Journal of Clinical Microbiology
  • A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure, 2020, Science Translational Medicine
  • A TfR-Binding Cystine-Dense Peptide Promotes Blood-Brain Barrier Penetration of Bioactive Molecules, 2020, Journal of Molecular Biology
  • Evaluation of SARS-CoV-2 neutralization assays for antibody monitoring in natural infection and vaccine trials, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • ARTEMIS: A Novel Mass-Spec Platform for HLA-Restricted Self and Disease-Associated Peptide Discovery, 2021, Frontiers in Immunology

Frequent collaboration is evident with a group of coauthors, including Peter B. Rupert, Matthew Buerger, Kathryn A. K. Finton, Della Friend, and Emily J. Girard. This network of collaborators indicates ongoing research partnerships and a breadth of expertise within related scientific areas.

Their studies have been published across multiple venues, with recurrent publications in Regular and Young Investigator Award Abstracts, Science Translational Medicine, Frontiers in Immunology, Structure, and Journal of Clinical Microbiology. These publications reflect diverse but related disciplines, aligned with molecular biology and immunological research.

Best Publications

  • Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.

    Trude H Flo;Kelly D Smith;Kelly D Smith;Shintaro Sato;David J Rodriguez

  • The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron Acquisition

    David H Goetz;Margaret A Holmes;Niels Borregaard;Martin E Bluhm

  • An iron delivery pathway mediated by a lipocalin

    Jun Yang;David Goetz;Jau Yi Li;Wenge Wang

  • Proof of principle for epitope-focused vaccine design

    Bruno Emanuel F. Sousa Correia;John T. Bates;Rebecca J. Loomis;Gretchen Baneyx

  • Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family

    Alexander Steinle;Pingwei Li;Daniel L. Morris;Veronika Groh

  • Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA.

    Pingwei Li;Daniel L. Morris;Benjamin E. Willcox;Alexander Steinle;Alexander Steinle

  • Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands

    Brett K Kaiser;Daesong Yim;I-Ting Chow;Segundo Gonzalez;Segundo Gonzalez

  • The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake

    Vibeke Hvidberg;Christian Jacobsen;Roland K. Strong;Jack B. Cowland

  • Lipocalin 2 promotes breast cancer progression.

    Jiang Yang;Diane R. Bielenberg;Scott J. Rodig;Robert Doiron

  • The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2

    Michael A. Fischbach;Hening Lin;Lu Zhou;Yang Yu

  • Iron traffics in circulation bound to a siderocalin (Ngal)–catechol complex

    Guanhu Bao;Matthew S Clifton;Trisha M. Hoette;Trisha M. Hoette;Kiyoshi Mori

  • HLA-E allelic variants: Correlating differential expression, peptide affinities, crystal structures and thermal stabilities

    Roland K. Strong;Margaret A. Holmes;Pingwei Li;Laura Braun

  • Siderocalin (Lcn 2) Also Binds Carboxymycobactins, Potentially Defending against Mycobacterial Infections through Iron Sequestration

    Margaret A. Holmes;Wendy Paulsene;Xu Jide;Colin Ratledge

  • Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope

    Bruno E. Correia;Yih En Andrew Ban;Margaret A. Holmes;Hengyu Xu

  • Interactions between NKG2x Immunoreceptors and HLA-E Ligands Display Overlapping Affinities and Thermodynamics

    Brett K. Kaiser;Fariba Barahmand-pour;Wendy Paulsene;Scott Medley

  • Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin

    David H. Goetz;Sirkku T. Willie;Roger S. Armen;Tomas Bratt

  • Lipocalin 2 Is Required for Pulmonary Host Defense against Klebsiella Infection

    Yvonne R. Chan;Jessica S. Liu;Derek A. Pociask;Mingquan Zheng

  • The structure of manganese superoxide dismutase from Thermus thermophilus HB8 at 2.4-A resolution.

    W C Stallings;K A Pattridge;R K Strong;M L Ludwig

  • Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand.

    Pingwei Li;Sirkku T. Willie;Stefan Bauer;Daniel L. Morris

  • Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold

    Mihai L. Azoitei;Bruno E. Correia;Bruno E. Correia;Yih En Andrew Ban;Chris Carrico;Chris Carrico

Frequent Co-Authors

Leonidas Stamatatos
Leonidas Stamatatos Fred Hutchinson Cancer Research Center
James M. Olson
James M. Olson Fred Hutchinson Cancer Research Center
Kenneth N. Raymond
Kenneth N. Raymond Lawrence Berkeley National Laboratory
William R. Schief
William R. Schief Scripps Research Institute
David Baker
David Baker University of Washington
Thomas Spies
Thomas Spies Fred Hutchinson Cancer Research Center
Kelly D. Smith
Kelly D. Smith University of Washington
Evgeni V. Sokurenko
Evgeni V. Sokurenko University of Washington
Philip D. Greenberg
Philip D. Greenberg Fred Hutchinson Cancer Research Center
Veronika Groh
Veronika Groh Fred Hutchinson Cancer Research Center

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