World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
21486
World Ranking
11119
National Ranking
797

Overview

Alexander Steinle is affiliated with Goethe University Frankfurt in Germany and specializes in immunology and microbiology, with notable contributions to medicine. Their research primarily focuses on immunology, oncology, and surgery, addressing various aspects of immune cell function and interaction.

Steinle's work concentrates on topics such as:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • CAR-T Cell Therapy Research
  • Galectins and Cancer Biology
  • IL-33, ST2, and ILC Pathways
  • Reproductive System and Pregnancy
  • Peptidase Inhibition and Analysis

The scientist has published numerous papers, with recent notable ones including:

  • "Engaging natural killer cells for cancer therapy via NKG2D, CD16A and other receptors", 2023, published in mAbs
  • "Increased Concentrations of Circulating Soluble MHC Class I-Related Chain A (sMICA) and sMICB and Modulation of Plasma Membrane MICA Expression: Potential Mechanisms and Correlation With Natural Killer Cell Activity in Systemic Lupus Erythematosus", 2021, published in Frontiers in Immunology
  • "MICAgen Mice Recapitulate the Highly Restricted but Activation-Inducible Expression of the Paradigmatic Human NKG2D Ligand MICA", 2020, published in Frontiers in Immunology
  • "Arming cytotoxic lymphocytes for cancer immunotherapy by means of the NKG2D/NKG2D-ligand system", 2020, published in Expert Opinion on Biological Therapy
  • "Editorial: ADAM10 in Cancer Immunology and Autoimmunity: More Than a Simple Biochemical Scissor", 2020, published in Frontiers in Immunology

Steinle frequently collaborates with other researchers, including Young-Hoon Kim, Mathieu Bléry, Mariya Lazarova, Manel Mrabet-Kraiem, and Ariane Morel. These coauthors contribute across various projects related to immune mechanisms and cancer immunotherapy.

Their publications have appeared predominantly in venues such as:

  • Frontiers in Immunology (3 publications)
  • Open Research Europe (2 publications)
  • PLoS ONE (2 publications)
  • mAbs (1 publication)
  • Expert Opinion on Biological Therapy (1 publication)

Best Publications

  • Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA

    Stefan Bauer;Veronika Groh;Jun Wu;Alexander Steinle

  • Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells

    Veronika Groh;Alexander Steinle;Stefan Bauer;Thomas Spies

  • NK cells and cancer immunosurveillance.

    I Waldhauer;A Steinle

  • Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding

    Helmut R. Salih;Hans-Georg Rammensee;Alexander Steinle

  • Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia

    Helmut Rainer Salih;Holger Antropius;Friederike Gieseke;Stefan Zoltan Lutz

  • Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family

    Alexander Steinle;Pingwei Li;Daniel L. Morris;Veronika Groh

  • Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA.

    Pingwei Li;Daniel L. Morris;Benjamin E. Willcox;Alexander Steinle;Alexander Steinle

  • Tumor-associated MICA is shed by ADAM proteases.

    Inja Waldhauer;Dennis Goehlsdorf;Friederike Gieseke;Toni Weinschenk

  • Prevalent expression of the immunostimulatory MHC class I chain–related molecule is counteracted by shedding in prostate cancer

    Jennifer D. Wu;Lily M. Higgins;Alexander Steinle;David Cosman

  • Natural Killer Cell–Mediated Lysis of Hepatoma Cells via Specific Induction of NKG2D Ligands by the Histone Deacetylase Inhibitor Sodium Valproate

    Sorin Armeanu;Michael Bitzer;Ulrich M. Lauer;Sascha Venturelli

  • RNA Interference Targeting Transforming Growth Factor-β Enhances NKG2D-Mediated Antiglioma Immune Response, Inhibits Glioma Cell Migration and Invasiveness, and Abrogates Tumorigenicity In vivo

    Manuel A. Friese;Jörg Wischhusen;Wolfgang Wick;Markus Weiler

  • Activation of Vγ9Vδ2 T Cells by NKG2D

    Bladimiro Rincon-Orozco;Volker Kunzmann;Philine Wrobel;Dieter Kabelitz

  • Activating natural cytotoxicity receptors of natural killer cells in cancer and infection.

    Joachim Koch;Alexander Steinle;Carsten Watzl;Ofer Mandelboim

  • Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein

    Stefan A. Welte;Christian Sinzger;Stefan Z. Lutz;Harpreet Singh‐Jasuja

  • Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma.

    Lizzia Raffaghello;Ignazia Prigione;Irma Airoldi;Marta Camoriano

  • Systemic NKG2D Down-Regulation Impairs NK and CD8 T Cell Responses In Vivo

    Katrin Wiemann;Hans-Willi Mittrücker;Ute Feger;Stefan A. Welte

  • MICA/NKG2D-Mediated Immunogene Therapy of Experimental Gliomas

    Manuel A. Friese;Michael Platten;Stefan Z. Lutz;Ulrike Naumann

  • Proteolytic release of soluble UL16-binding protein 2 from tumor cells.

    Inja Waldhauer;Alexander Steinle

  • Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction

    Stefan Welte;Sabrina Kuttruff;Inja Waldhauer;Alexander Steinle

  • Soluble MICA in malignant diseases.

    Stefan Holdenrieder;Petra Stieber;Andrea Peterfi;Dorothea Nagel

Frequent Co-Authors

Lothar Kanz
Lothar Kanz University of Tübingen
Michael Weller
Michael Weller University of Zurich
Hans-Georg Rammensee
Hans-Georg Rammensee University of Tübingen
Manuel A. Friese
Manuel A. Friese Universität Hamburg
Veronika Groh
Veronika Groh Fred Hutchinson Cancer Research Center
Thomas Spies
Thomas Spies Fred Hutchinson Cancer Research Center
Stefan Bauer
Stefan Bauer Philipp University of Marburg
Adelheid Cerwenka
Adelheid Cerwenka Heidelberg University
Heinz Wiendl
Heinz Wiendl University of Münster
Andreas Trumpp
Andreas Trumpp German Cancer Research Center

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