World's Best Scientists 2026 revealed!
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Immunology
Italy
2026
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Medicine
Italy
2023

D-Index & Metrics

Immunology

D-Index
164
Citations
99469
World Ranking
67
National Ranking
3

Medicine

D-Index
164
Citations
99495
World Ranking
662
National Ranking
17

Research.com Recognitions

  • 2026 - Research.com Immunology in Italy Leader Award
  • 2025 - Research.com Immunology in Italy Leader Award
  • 2023 - Research.com Immunology in Italy Leader Award
  • 2023 - Research.com Medicine in Italy Leader Award
  • 2022 - Research.com Immunology in Italy Leader Award
  • 1991 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Immune system
  • Cancer

His primary areas of study are Immunology, Cell biology, Interleukin 21, Receptor and Lymphokine-activated killer cell. His work carried out in the field of Immunology brings together such families of science as Natural killer cell and Transplantation. He has researched Cell biology in several fields, including NKG2D, Nectin and Cytokine.

His Interleukin 21 research includes themes of IL-2 receptor, Antigen-presenting cell, Natural killer T cell, CD16 and Interleukin 12. The Receptor study combines topics in areas such as Molecular biology, Natural Cytotoxicity Triggering Receptor 1, Major histocompatibility complex and Cytotoxicity. His Lymphokine-activated killer cell research includes elements of Stromal cell, Janus kinase 3, Myeloid-derived Suppressor Cell, NK-92 and Innate lymphoid cell.

His most cited work include:

  • Mesenchymal stem cells in health and disease (2397 citations)
  • Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis (1532 citations)
  • Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG. (999 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Immunology, Cell biology, Receptor, Interleukin 21 and Molecular biology. His study in Immunology is interdisciplinary in nature, drawing from both Natural killer cell, Cytotoxic T cell and Transplantation. His Cell biology research is multidisciplinary, relying on both NKG2D, Cellular differentiation, MHC class I and Innate lymphoid cell.

His research in Receptor tackles topics such as Cell which are related to areas like Cancer research. His work deals with themes such as Innate immune system, Interleukin 12 and Antigen-presenting cell, which intersect with Interleukin 21. His Lymphokine-activated killer cell study combines topics from a wide range of disciplines, such as NK-92 and Natural killer T cell.

He most often published in these fields:

  • Immunology (57.44%)
  • Cell biology (41.66%)
  • Receptor (37.90%)

What were the highlights of his more recent work (between 2013-2021)?

  • Immunology (57.44%)
  • Immune system (16.30%)
  • Cancer research (12.03%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Immunology, Immune system, Cancer research, Cell biology and Innate lymphoid cell. His research integrates issues of Interleukin 12, Receptor and Hematopoietic stem cell transplantation in his study of Immunology. His Immune system research is multidisciplinary, incorporating perspectives in Stromal cell, Haematopoiesis and Virology.

Lorenzo Moretta has included themes like Cell, Cell culture, Downregulation and upregulation and Immunotherapy in his Cancer research study. His Cell biology study integrates concerns from other disciplines, such as Chemokine and Cellular differentiation. His Human leukocyte antigen research incorporates elements of Natural killer cell and CD19.

Between 2013 and 2021, his most popular works were:

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) (345 citations)
  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (301 citations)
  • HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders (282 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • Cancer

The scientist’s investigation covers issues in Immunology, Immune system, Cell biology, Receptor and Interleukin 12. His study in Lymphokine-activated killer cell, Interleukin 21, Innate lymphoid cell and NK-92 falls under the purview of Immunology. His Immune system study combines topics in areas such as Cell, Cancer research and Monoclonal antibody.

In general Cell biology study, his work on Progenitor cell often relates to the realm of Decidua, thereby connecting several areas of interest. His Receptor study incorporates themes from Virus, Viral entry, Metastasis, Tertiary Lymphoid Structures and Cytotoxicity. His work in Interleukin 12 addresses issues such as Tumor necrosis factor alpha, which are connected to fields such as CD49b and Eomesodermin.

Best Publications

  • Mesenchymal stem cells in health and disease

    Antonio Uccelli;Lorenzo Moretta;Vito Pistoia

  • Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.

    Alessandro Moretta;Cristina Bottino;Massimo Vitale;Daniela Pende

  • Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG.

    L Moretta;S R Webb;C E Grossi;P M Lydyard

  • Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: Role of indoleamine 2,3-dioxygenase and prostaglandin E2

    Grazia Maria Spaggiari;Andrea Capobianco;Heba Abdelrazik;Flavio Becchetti

  • Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation

    Grazia Maria Spaggiari;Andrea Capobianco;Stelvio Becchetti;Maria Cristina Mingari

  • Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells.

    Guido Ferlazzo;Ming L. Tsang;Lorenzo Moretta;Lorenzo Moretta;Giovanni Melioli

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Mübeccel Akdis

  • Identification of PVR (CD155) and Nectin-2 (CD112) as Cell Surface Ligands for the Human DNAM-1 (CD226) Activating Molecule

    Cristina Bottino;Roberta Castriconi;Daniela Pende;Paola Rivera

  • RECEPTORS FOR HLA CLASS-I MOLECULES IN HUMAN NATURAL KILLER CELLS

    Alessandro Moretta;Cristina Bottino;Massimo Vitale;Daniela Pende

  • Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells

    Daniela Pende;Silvia Parolini;Anna Pessino;Simona Sivori

  • NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis

    Massimo Vitale;Cristina Bottino;Simona Sivori;Lorenza Sanseverino

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs

  • Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells

    Roberta Castriconi;Claudia Cantoni;Mariella Della Chiesa;Massimo Vitale

  • MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2

    Grazia Maria Spaggiari;Heba Abdelrazik;Heba Abdelrazik;Flavio Becchetti;Lorenzo Moretta;Lorenzo Moretta

  • P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.

    Alessandro Moretta;Massimo Vitale;Cristina Bottino;Anna Maria Orengo

  • COVID-19 vaccines: where we stand and challenges ahead.

    Guido Forni;Alberto Mantovani;Alberto Mantovani

  • Unravelling natural killer cell function: triggering and inhibitory human NK receptors.

    Lorenzo Moretta;Lorenzo Moretta;Alessandro Moretta

  • Immunoregulatory function of mesenchymal stem cells

    Antonio Uccelli;Lorenzo Moretta;Vito Pistoia

  • Major Histocompatibility Complex Class I-related Chain A and UL16-Binding Protein Expression on Tumor Cell Lines of Different Histotypes Analysis of Tumor Susceptibility to NKG2D-dependent Natural Killer Cell Cytotoxicity

    Daniela Pende;Paola Rivera;Stefania Marcenaro;Chien Chung Chang

  • Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity.

    Anna Pessino;Simona Sivori;Cristina Bottino;Angela Malaspina

Frequent Co-Authors

Alessandro Moretta
Alessandro Moretta University of Genoa
Maria Cristina Mingari
Maria Cristina Mingari University of Genoa
Cristina Bottino
Cristina Bottino University of Genoa
Daniela Pende
Daniela Pende University of Genoa
Claudia Cantoni
Claudia Cantoni University of Genoa
Roberto Biassoni
Roberto Biassoni Istituto Giannina Gaslini
Michela Falco
Michela Falco Istituto Giannina Gaslini
Paola Vacca
Paola Vacca University of Genoa
Massimo Vitale
Massimo Vitale University of Genoa
Simona Sivori
Simona Sivori University of Genoa

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Related Online Degrees & Career Pathways

For those interested in Immunology, exploring related healthcare degrees can open diverse career opportunities. Many students transition into specialized nursing roles, and accelerated programs make this more accessible than ever.

For example, an accelerated nurse practitioner program offers advanced training in patient care and immunological health, allowing graduates to work directly with immune-related diseases and treatments. These programs provide a quick yet thorough path to a rewarding career.

Newcomers to healthcare can begin with an online adn programs for non nurses, which equips learners without a nursing background with foundational skills. This is a flexible way to enter the healthcare field and later specialize in immunology-related areas.

Similarly, accelerated bsn programs for non nurses help expedite the route to becoming a registered nurse, providing essential clinical knowledge applicable to immunological studies and patient care.

For those seeking entry-level credentials, several accredited lpn programs easy to get into offer practical training to begin working in healthcare settings quickly. This can serve as a stepping stone to advanced immunology-focused education and careers.

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