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Miguel López-Botet

Miguel López-Botet

D-Index & Metrics

Immunology

D-Index
78
Citations
20601
World Ranking
1760
National Ranking
16

Overview

Miguel López-Botet is affiliated with Pompeu Fabra University in Spain and has contributed extensively to research primarily within the fields of immunology and microbiology as well as medicine. They have a scholarly focus on immunology, oncology, epidemiology, molecular biology, and transplantation. Their research topics center largely on immune cell function and interaction, T-cell and B-cell immunology, cytomegalovirus and herpesvirus research, IL-33, ST2, and ILC pathways, renal transplantation outcomes and treatments, melanoma and MAPK pathways, and mechanisms of cell death and regulation.

The scientist's recent publications reflect a range of immunological and clinical interests. Notable papers include:

  • "Haplotype-Based Analysis of KIR-Gene Profiles in a South European Population-Distribution of Standard and Variant Haplotypes, and Identification of Novel Recombinant Structures" (2020, Frontiers in Immunology)
  • "Adaptive NK cell response to human cytomegalovirus: Facts and open issues" (2022, Seminars in Immunology)
  • "NK cell-triggered CCL5/IFNγ-CXCL9/10 axis underlies the clinical efficacy of neoadjuvant anti-HER2 antibodies in breast cancer" (2024, Journal of Experimental & Clinical Cancer Research)
  • "Impact of cytomegalovirus infection on B cell differentiation and cytokine production in multiple sclerosis" (2020, Journal of Neuroinflammation)
  • "Microvascular inflammation in the absence of human leukocyte antigen-donor-specific antibody and C4d: An orphan category in Banff classification with cytotoxic T and natural killer cell infiltration" (2023, American Journal of Transplantation)

López-Botet collaborates frequently with several coauthors, among them Aura Muntasell, Carlos Vilches, Elisenda Alari-Pahissa, José Yélamos, and Mireia Altadill. These collaborators have contributed to a number of publications alongside López-Botet, indicating ongoing research partnerships.

Frequent venues for López-Botet's research publications include:

  • HLA
  • American Journal of Transplantation
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Seminars in Immunology

Best Publications

  • HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A.

    Ni Lee;Manuel Llano;Marta Carretero;Akiko Ishitani

  • A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells

    Marco Colonna;Francisco Navarro;Teresa Bellón;Manuel Llano

  • IMPLICATIONS FOR IMMUNOSURVEILLANCE OF ALTERED HLA CLASS I PHENOTYPES IN HUMAN TUMOURS

    Federico Garrido;Francisco Ruiz-Cabello;Teresa Cabrera;Juan J. Pérez-Villar

  • Imprint of human cytomegalovirus infection on the NK cell receptor repertoire.

    Mónica Gumá;Ana Angulo;Carlos Vilches;Natalia Gómez-Lozano

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs

  • Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts

    Mónica Gumá;Matthias Budt;Andrea Sáez;Tamara Brckalo

  • Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E.

    Mar Valés‐Gómez;Hugh T. Reyburn;Robert A. Erskine;Miguel López‐Botet

  • HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer

    Manuel Llano;Ni Lee;Francisco Navarro;Pilar García

  • The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells

    Francisco Navarro;Manuel Llano;Teresa Bellón;Marco Colonna

  • Triggering of T cell proliferation through AIM, an activation inducer molecule expressed on activated human lymphocytes.

    M Cebrián;E Yagüe;M Rincón;M López-Botet

  • The CD94 and NKG2‐A C‐type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules

    Marta Carretero;Claudia Cantoni;Teresa Bellón;Cristina Bottino

  • Human cytomegalovirus infection is associated with increased proportions of NK cells that express the CD94/NKG2C receptor in aviremic HIV-1-positive patients.

    Mónica Gumá;Cecilia Cabrera;Itziar Erkizia;Margarita Bofill

  • Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily.

    Chiwen Chang;Antonio Rodríguez;Marta Carretero;Miguel López-Botet

  • Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C.

    K S Campbell;M Dessing;M Lopez-Botet;M Cella

  • MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine

    J. Bousquet;J. Anto;C. Auffray;M. Akdis

  • Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles.

    Alessandro Moretta;Massimo Vitale;Simona Sivori;Cristina Bottino

  • A NOVEL FAMILY OF IG-LIKE RECEPTORS FOR HLA CLASS I MOLECULES THAT MODULATE FUNCTION OF LYMPHOID AND MYELOID CELLS

    Marco Colonna;Hideo Nakajima;Francisco Navarro;Miguel López-Botet

  • NK cell recognition of non-classical HLA class I molecules

    Miguel López-Botet;Manuel Llano;Francisco Navarro;Teresa Bellon

  • CMV and Immunosenescence: from basics to clinics

    Rafael Solana;Raquel Tarazona;Allison E Aiello;Arne N Akbar

  • CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes.

    Fabrizio Poccia;Barbara Cipriani;Silvia Vendetti;Vittorio Colizzi

Frequent Co-Authors

Francisco Sánchez-Madrid
Francisco Sánchez-Madrid Autonomous University of Madrid
Lorenzo Moretta
Lorenzo Moretta Bambino Gesù Children's Hospital
Alessandro Moretta
Alessandro Moretta University of Genoa
María A. Balboa
María A. Balboa Spanish National Research Council
Ignacio Melero
Ignacio Melero University of Oxford
Marco Colonna
Marco Colonna Washington University in St. Louis
Daniel E. Geraghty
Daniel E. Geraghty Fred Hutchinson Cancer Research Center
Lewis L. Lanier
Lewis L. Lanier University of California, San Francisco
Daniela Pende
Daniela Pende University of Genoa
Julio Pascual
Julio Pascual University of Cantabria

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