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Edgardo D. Carosella

Edgardo D. Carosella

D-Index & Metrics

Immunology

D-Index
95
Citations
30168
World Ranking
907
National Ranking
29

Medicine

D-Index
95
Citations
30198
World Ranking
10138
National Ranking
311

Overview

Edgardo D. Carosella is affiliated with Université Paris Cité in France. Their research activity spans several areas within medicine and immunology, with a notable focus on immune system regulation and reproductive biology.

Their research primarily falls under the main fields of Medicine and Immunology and Microbiology. Within these fields, their subfields of study include Immunology, Oncology, Genetics, Molecular Biology, and Reproductive Medicine. The main topics that characterize their work are Reproductive System and Pregnancy, Immune Cell Function and Interaction, Mesenchymal Stem Cell Research, Immunotherapy and Immune Responses, Endometriosis Research and Treatment, Wound Healing and Treatments, and Ovarian Cancer Diagnosis and Treatment.

Edgardo D. Carosella's recent scholarly contributions include the following papers:

  • HLA-G/LILRBs: A Cancer Immunotherapy Challenge, 2021, Trends in cancer
  • Soluble HLA-G and HLA-G Bearing Extracellular Vesicles Affect ILT-2 Positive and ILT-2 Negative CD8 T Cells Complementary, 2020, Frontiers in Immunology
  • Comprehensive landscape of immune-checkpoints uncovered in clear cell renal cell carcinoma reveals new and emerging therapeutic targets, 2020, Cancer Immunology Immunotherapy
  • The immune-checkpoint HLA-G/ILT4 is involved in the regulation of VEGF expression in clear cell renal cell carcinoma, 2020, BMC Cancer
  • Role of the HLA-G immune checkpoint molecule in pregnancy, 2021, Human Immunology

Their frequent co-authors include:

  • Nathalie Rouas-Freiss
  • Joël LeMaoult
  • Diana Tronik-Le Roux
  • María Belén Palma
  • François Desgrandchamps

Edgardo D. Carosella has published multiple works in several prominent academic venues, including:

  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Immunology Immunotherapy
  • Human Immunology
  • International Journal of Molecular Sciences

The core of their research concentrates on mechanisms of immune-checkpoint molecules such as HLA-G, investigating their roles in cancer immunotherapy and pregnancy. Their publications demonstrate an integration of oncology, immunological checkpoints, and reproductive immunology, reflecting interdisciplinary approaches within their scientific inquiries.

Best Publications

  • Human Leukocyte Antigen‐G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+ Regulatory T Cells

    Zohair Selmani;Abderrahim Naji;Ines Zidi;Benoit Favier

  • Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis

    Nathalie Rouas-Freiss;Rachel Marchal-Bras Gonçalves;Catherine Menier;Jean Dausset

  • HLA-G expression in melanoma: A way for tumor cells to escape from immunosurveillance

    P Paul;N Rouas-Freiss;I Khalil-Daher;P Moreau

  • IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes

    Philippe Moreau;Francisco Adrian-Cabestre;Catherine Menier;Virginie Guiard

  • The 14 bp Deletion-Insertion polymorphism in the 3′ UT region of the HLA-G gene influences HLA-G mRNA stability

    Philippe Rousseau;Magali Le Discorde;Gaël Mouillot;Céline Marcou

  • The alpha1 domain of HLA-G1 and HLA-G2 inhibits cytotoxicity induced by natural killer cells: is HLA-G the public ligand for natural killer cell inhibitory receptors?

    Nathalie Rouas-Freiss;Rachel E. Marchal;Marek Kirszenbaum;Jean Dausset

  • HLA-G: from biology to clinical benefits

    Edgardo D. Carosella;Philippe Moreau;Joël LeMaoult;Nathalie Rouas-Freiss

  • HLA-G molecules: from maternal-fetal tolerance to tissue acceptance.

    Edgardo D Carosella;Philippe Moreau;Joël Le Maoult;Magali Le Discorde

  • HLA-G2, -G3, and -G4 Isoforms Expressed as Nonmature Cell Surface Glycoproteins Inhibit NK and Antigen-Specific CTL Cytolysis

    Béatrice Riteau;Nathalie Rouas-Freiss;Catherine Menier;Pascale Paul

  • Soluble HLA-G protein secreted by allo-specific CD4+ T cells suppresses the allo-proliferative response: A CD4+ T cell regulatory mechanism

    Nermine Lila;Nathalie Rouas-Freiss;Jean Dausset;Alain Carpentier

  • HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+ T cells

    Joël LeMaoult;Irène Krawice-Radanne;Jean Dausset;Edgardo D. Carosella

  • HLA-G: An Immune Checkpoint Molecule.

    Edgardo D Carosella;Nathalie Rouas-Freiss;Diana Tronik-Le Roux;Philippe Moreau

  • Identification of HLA-G7 as a new splice variant of the HLA-G mRNA and expression of soluble HLA-G5, -G6, and -G7 transcripts in human transfected cells.

    Pascale Paul;Franscisco Adrian Cabestre;El Chérif Ibrahim;Sophie Lefebvre

  • Beyond the increasing complexity of the immunomodulatory HLA-G molecule.

    Edgardo D. Carosella;Benoit Favier;Nathalie Rouas-Freiss;Philippe Moreau

  • HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes.

    Frédérique-Anne Le Gal;Béatrice Riteau;Christine Sedlik;Iman Khalil-Daher

  • HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells.

    Joël Lemaoult;Kamélia Zafaranloo;Caroline Le Danff;Edgardo D. Carosella

  • Human Leukocyte Antigen-G Expression After Heart Transplantation Is Associated With a Reduced Incidence of Rejection

    Nermine Lila;Catherine Amrein;Romain Guillemain;Patrick Chevalier

  • Expression of HLA-G in human cornea, an immune-privileged tissue.

    Magali Le Discorde;Philippe Moreau;Patrick Sabatier;Jean-Marc Legeais

  • HLA-G proteins in cancer: do they provide tumor cells with an escape mechanism?

    Nathalie Rouas-Freiss;Philippe Moreau;Soldano Ferrone;Edgardo D. Carosella

  • Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells

    Joel LeMaoult;Julien Caumartin;Marina Daouya;Benoit Favier

  • An alternatively spliced form of HLA-G mRNA in human trophoblasts and evidence for the presence of HLA-G transcript in adult lymphocytes.

    Marek Kirszenbaum;Philippe Moreau;Eliane Gluckman;Jean Dausset

Frequent Co-Authors

Nathalie Rouas-Freiss
Nathalie Rouas-Freiss French Alternative Energies and Atomic Energy Commission (CEA)
Jean Dausset
Jean Dausset Grenoble Alpes University
Joel LeMaoult
Joel LeMaoult Université Paris Cité
Philippe Moreau
Philippe Moreau University of Nantes
Pascale Paul
Pascale Paul Aix-Marseille University
Eliane Gluckman
Eliane Gluckman Université Paris Cité
Eduardo Antônio Donadi
Eduardo Antônio Donadi Universidade de São Paulo
Soldano Ferrone
Soldano Ferrone Harvard University
Jean-Gérard Guillet
Jean-Gérard Guillet Grenoble Alpes University
Armand Bensussan
Armand Bensussan Hôpital Saint-Louis

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