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Bo Åkerström

Bo Åkerström

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
9989
World Ranking
14000
National Ranking
206

Overview

Bo Åkerström is affiliated with Lund University in Sweden and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research focuses on molecular biology, cell biology, physiology, nephrology, and cancer research. The scientist's work encompasses several specific topics including erythrocyte function and pathophysiology, heme oxygenase-1 and carbon monoxide, acute kidney injury research, hemoglobin structure and function, endoplasmic reticulum stress and disease, alcohol consumption and health effects, and the intersection of cancer, hypoxia, and metabolism.

Frequent co-authors who have collaborated on multiple occasions with Bo Åkerström include Amanda Kristiansson, Magnus Gram, Stefan R. Hansson, Jesper Bergwik, and Johan Flygare.

Bo Åkerström has published research in a variety of scientific journals, with notable frequency in the following venues:

  • International Journal of Molecular Sciences
  • Free Radical Biology and Medicine
  • Frontiers in Physiology
  • Redox Biology
  • Frontiers in Plant Science

Highlighted recent papers authored or co-authored by Bo Åkerström include:

  • The Role of α1-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis-Therapeutic Opportunities in Hemolytic Conditions, 2020, International Journal of Molecular Sciences
  • Human radical scavenger α1-microglobulin protects against hemolysis in vitro and α1-microglobulin knockout mice exhibit a macrocytic anemia phenotype, 2020, Free Radical Biology and Medicine
  • α1-Microglobulin (A1M) Protects Human Proximal Tubule Epithelial Cells from Heme-Induced Damage In Vitro, 2020, International Journal of Molecular Sciences
  • Knockout of the radical scavenger α1-microglobulin in mice results in defective bikunin synthesis, endoplasmic reticulum stress and increased body weight, 2020, Free Radical Biology and Medicine
  • Editorial: Functional Profile of the Lipocalin Protein Family, 2022, Frontiers in Physiology

Bo Åkerström's body of work primarily explores the biochemistry and molecular mechanisms underlying erythrocyte biology and hemolytic conditions, with particular attention to the role of α1-microglobulin (A1M). The studies investigate cellular protective mechanisms against oxidative damage, effects on kidney epithelial cells, and links to endoplasmic reticulum stress. Their research reflects multidisciplinary approaches intersecting molecular biology and physiology as well as clinical medicine contexts related to hematology and nephrology.

Best Publications

  • Protein G: a powerful tool for binding and detection of monoclonal and polyclonal antibodies

    B Akerström;T Brodin;K Reis;L Björck

  • A physicochemical study of protein G, a molecule with unique immunoglobulin G-binding properties

    B Akerström;L Björck

  • Positional identification of Ncf1 as a gene that regulates arthritis severity in rats.

    Peter Olofsson;Jens Holmberg;Jesper Tordsson;Shemin Lu

  • Lipocalins: unity in diversity.

    Bo Åkerstrom;Darren R. Flower;Jean-Philippe Salier

  • Protein L from Peptostreptococcus magnus binds to the kappa light chain variable domain.

    B. H. K. Nilson;A. Solomon;L. Björck;B. Åkerström

  • Review: Biochemical markers to predict preeclampsia.

    Ulrik Dolberg Anderson;M G Olsson;Karl Kristensen;Bo Åkerström

  • Protein L: an immunoglobulin light chain-binding bacterial protein. Characterization of binding and physicochemical properties.

    B Akerström;L Björck

  • An intriguing member of the lipocalin protein family : α1-microglobulin

    Bo Åkerström;Lennart Lögdberg

  • Definition of IgG- and albumin-binding regions of streptococcal protein G

    B Akerström;E Nielsen;L Björck

  • alpha(1)-Microglobulin: a yellow-brown lipocalin

    Bo Åkerström;Lennart Lögdberg;Tord Berggård;Peter Osmark

  • The Yersinia Protein Kinase A Is a Host Factor Inducible RhoA/Rac-binding Virulence Factor

    Jean Marie Dukuzumuremyi;Roland Rosqvist;Bengt Hallberg;Bo Åkerström

  • Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties.

    Maria Allhorn;Tord Berggård;Jonas Nordberg;Martin L. Olsson

  • Purification of antibodies using protein L-binding framework structures in the light chain variable domain.

    Bo H.K. Nilson;Lennart Lögdberg;William Kastern;Lars Björck

  • Redox properties of the lipocalin α1-microglobulin: Reduction of cytochrome c, hemoglobin, and free iron

    Maria Allhorn;Anna Klapyta;Bo Åkerström

  • Increased levels of cell-free hemoglobin, oxidation markers, and the antioxidative heme scavenger alpha(1)-microglobulin in preeclampsia.

    Magnus G. Olsson;Magnus Centlow;Sigurbjörg Rutardóttir;Iréne Stenfors

  • The Lipocalin α1-Microglobulin Has Radical Scavenging Activity

    Bo Åkerström;Ghassan J. Maghzal;Christine C. Winterbourn;Anthony J. Kettle

  • Hemoglobin induces inflammation after preterm intraventricular hemorrhage by methemoglobin formation

    Magnus Gram;Snjolaug Sveinsdottir;Karsten Ruscher;Stefan R Hansson

  • Fetal hemoglobin and α1-microglobulin as first- and early second-trimester predictive biomarkers for preeclampsia.

    Ulrik Dolberg Anderson;Magnus G. Olsson;Sigurbjörg Rutardóttir;Magnus Centlow

  • Pathological Conditions Involving Extracellular Hemoglobin: Molecular Mechanisms, Clinical Significance, and Novel Therapeutic Opportunities for alpha(1)-Microglobulin

    Magnus G Olsson;Maria Allhorn;Leif Bülow;Stefan R Hansson

  • Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by α1-microglobulin

    K May;Lena Rosenlöf;M G Olsson;M Centlow

Frequent Co-Authors

Lars Björck
Lars Björck Lund University
Martin L. Olsson
Martin L. Olsson Lund University
Matthias Mörgelin
Matthias Mörgelin Lund University
Jan J. Enghild
Jan J. Enghild Aarhus University
Eero Kajantie
Eero Kajantie Finnish Institute for Health and Welfare (THL)
Abdu I. Alayash
Abdu I. Alayash US Food and Drug Administration
Gunnar Lindahl
Gunnar Lindahl Lund University
Artur Schmidtchen
Artur Schmidtchen Lund University
Rikard Holmdahl
Rikard Holmdahl Karolinska Institute
Katri Räikkönen
Katri Räikkönen University of Helsinki

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