World's Best Scientists 2026 revealed!

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Biology and Biochemistry

D-Index
59
Citations
17768
World Ranking
12319
National Ranking
5274

Overview

James M. Wells is affiliated with Cincinnati Children's Hospital Medical Center in the United States. Their research activities center on the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with a substantive focus on Molecular Biology and Surgery.

The scientist's work spans a range of topics including Cancer Cells and Metastasis, Pluripotent Stem Cells Research, Pancreatic function and diabetes, Renal and related cancers, Digestive system and related health, 3D Printing in Biomedical Research, and Tracheal and airway disorders.

Frequent publication venues for their research include bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Cell stem cell, Cellular and Molecular Gastroenterology and Hepatology, and Development.

Collaborations have been consistent with several coauthors, including Michael A. Helmrath, J. Guillermo Sanchez, Takanori Takebe, Holly M. Poling, and Heather A. McCauley.

Recent papers authored or coauthored by James M. Wells highlight diverse areas of developmental biology and organoid technology. These papers include:

  • Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis (2020, Nature Communications)
  • Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells (2021, Cell stem cell)
  • In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice (2023, Nature Biotechnology)
  • A dietary change to a high-fat diet initiates a rapid adaptation of the intestine (2022, Cell Reports)
  • Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport (2020, Nature Communications)

Best Publications

  • Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

    Jason R. Spence;Christopher N. Mayhew;Scott A. Rankin;Matthew F. Kuhar

  • Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

    Kyle W. McCracken;Emily M. Catá;Calyn M. Crawford;Katie L. Sinagoga

  • Vertebrate Endoderm Development and Organ Formation

    Aaron M. Zorn;James M. Wells

  • In vitro generation of human pluripotent stem cell derived lung organoids

    Briana R Dye;David R Hill;Michael A H Ferguson;Yu-Hwai Tsai

  • VERTEBRATE ENDODERM DEVELOPMENT

    James M. Wells;Douglas A. Melton

  • Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

    Michael J. Workman;Maxime M. Mahe;Stephen Trisno;Holly M. Poling

  • An in vivo model of human small intestine using pluripotent stem cells

    Carey L Watson;Maxime M Mahe;Jorge Múnera;Jonathan C Howell

  • Early mouse endoderm is patterned by soluble factors from adjacent germ layers.

    James M. Wells;Douglas A. Melton

  • Generating human intestinal tissue from pluripotent stem cells in vitro.

    Kyle W McCracken;Jonathan C Howell;James M Wells;Jason R Spence

  • Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids

    Rie Ouchi;Shodai Togo;Masaki Kimura;Tadahiro Shinozawa

  • Sox17 and Sox4 Differentially Regulate β-Catenin/T-Cell Factor Activity and Proliferation of Colon Carcinoma Cells

    Débora Sinner;Jennifer J. Kordich;Jason R. Spence;Robert Opoka

  • Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung.

    Amanda E. Serls;Shawna Doherty;Pankhuri Parvatiyar;James M. Wells

  • Sox17 Regulates Organ Lineage Segregation of Ventral Foregut Progenitor Cells

    Jason R. Spence;Alex W. Lange;Suh Chin J. Lin;Klaus H. Kaestner

  • Organoids by design.

    Takanori Takebe;James M. Wells

  • Global expression analysis of gene regulatory pathways during endocrine pancreatic development.

    Guoqiang Gu;James M. Wells;David Dombkowski;Fred Preffer

  • Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish.

    Heather A. McCauley;James M. Wells

  • Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary

    Hiroyuki Koike;Kentaro Iwasawa;Rie Ouchi;Mari Maezawa

  • Wnt/β-catenin promotes gastric fundus specification in mice and humans

    Kyle W. McCracken;Eitaro Aihara;Baptiste Martin;Calyn M. Crawford

  • Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling.

    Jorge O. Múnera;Nambirajan Sundaram;Scott A. Rankin;David Hill

  • Transdifferentiation of ciliated cells during repair of the respiratory epithelium.

    Kwon-Sik Park;James M. Wells;Aaron M. Zorn;Susan E. Wert

Frequent Co-Authors

Aaron M. Zorn
Aaron M. Zorn Cincinnati Children's Hospital Medical Center
Jason R. Spence
Jason R. Spence University of Michigan–Ann Arbor
Noah F. Shroyer
Noah F. Shroyer Baylor College of Medicine
Howard C. Crawford
Howard C. Crawford University of Michigan–Ann Arbor
Marshall H. Montrose
Marshall H. Montrose University of Cincinnati
Vladimir V. Kalinichenko
Vladimir V. Kalinichenko Cincinnati Children's Hospital Medical Center
Douglas A. Melton
Douglas A. Melton Harvard University
Len A. Pennacchio
Len A. Pennacchio Lawrence Berkeley National Laboratory
Axel Visel
Axel Visel Lawrence Berkeley National Laboratory
Andrew G. Elefanty
Andrew G. Elefanty University of Melbourne

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