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D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
23828
World Ranking
4063
National Ranking
1999

Overview

Matthias Hebrok is affiliated with the University of California, San Francisco, United States. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology, with significant contributions within subfields such as surgery, molecular biology, genetics, endocrinology, diabetes and metabolism, and immunology.

The core topics of their research include pancreatic function and diabetes, diabetes management and research, diabetes and associated disorders, immune cell function and interaction, pancreatic and hepatic oncology research, pluripotent stem cells research, and CRISPR and genetic engineering.

Matthias Hebrok has published in various scientific venues, with frequent publications appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • JCI Insight
  • Nature Reviews Endocrinology
  • Nature Communications

Some of their recent papers include:

  • Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy, 2020, Nature Reviews Endocrinology
  • Stem Cell-Based Clinical Trials for Diabetes Mellitus, 2021, Frontiers in Endocrinology
  • Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection, 2021, Cell Reports
  • Loss of the transcription factor MAFB limits β-cell derivation from human PSCs, 2020, Nature Communications
  • Mutations and variants of ONECUT1 in diabetes, 2021, Nature Medicine

Frequent co-authors collaborating with Matthias Hebrok include:

  • Sudipta Ashe
  • David I. Berrios
  • Audrey M. Hendley
  • Valerie M. Weaver
  • Gopika G. Nair

Best Publications

  • Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

    Sarah P. Thayer;Marina Pasca di Magliano;Patrick W. Heiser;Corinne M. Nielsen

  • Hedgehog signalling in cancer formation and maintenance.

    Marina Pasca di Magliano;Matthias Hebrok

  • Notochord repression of endodermal Sonic hedgehog permits pancreas development

    Matthias Hebrok;Seung K. Kim;Douglas A. Melton

  • Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

    Janel L. Kopp;Guido von Figura;Erin Mayes;Fen-Fen Liu

  • KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.

    John P. Morris;Sam C. Wang;Matthias Hebrok

  • Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells

    Yuki Ohi;Han Qin;Chibo Hong;Laure Blouin

  • Controlled Induction of Human Pancreatic Progenitors Produces Functional Beta-Like Cells

    Matthias Hebrok;Holger Andreas Russ

  • Intercellular signals regulating pancreas development and function

    Seung K. Kim;Matthias Hebrok

  • Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression

    Akihisa Fukuda;Sam C. Wang;John P. Morris;Alexandra E. Folias

  • Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

    Hanane Laklai;Yekaterina A Miroshnikova;Michael W Pickup;Eric A Collisson

  • Notochord to endoderm signaling is required for pancreas development

    Seung K. Kim;Matthias Hebrok;Douglas A. Melton

  • Regulation of pancreas development by hedgehog signaling.

    M. Hebrok;S.K. Kim;B. St Jacques;A.P. McMahon

  • GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

    Olivier Nolan-Stevaux;Janet Lau;Morgan L. Truitt;Gerald C. Chu

  • Wnt signaling regulates pancreatic β cell proliferation

    Ingrid C. Rulifson;Satyajit K. Karnik;Patrick W. Heiser;Derk ten Berge

  • β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice

    John P. Morris;David A. Cano;David A. Cano;Shigeki Sekine;Shigeki Sekine;Sam C. Wang

  • Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.

    Gopika G Nair;Jennifer S Liu;Holger A Russ;Holger A Russ;Stella Tran;Stella Tran

  • Human islets contain four distinct subtypes of β cells.

    Craig Dorrell;Jonathan Schug;Pamela S. Canaday;Holger A. Russ

  • Hedgehog/Ras interactions regulate early stages of pancreatic cancer.

    Marina Pasca di Magliano;Shigeki Sekine;Alexandre Ermilov;Jenny Ferris

  • Liver-specific loss of β-catenin blocks glutamine synthesis pathway activity and cytochrome P450 expression in mice

    Shigeki Sekine;Billy Yu-Ang Lan;Melanie Bedolli;Sandy Feng

  • Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis

    Jennifer P. Morton;Michelle E. Mongeau;David S. Klimstra;John P. Morris

Frequent Co-Authors

Marina Pasca di Magliano
Marina Pasca di Magliano University of Michigan–Ann Arbor
Seung K. Kim
Seung K. Kim Stanford University
Douglas A. Melton
Douglas A. Melton Harvard University
Eric A. Collisson
Eric A. Collisson University of California, San Francisco
Jeffrey A. Bluestone
Jeffrey A. Bluestone University of California, San Francisco
Christopher V.E. Wright
Christopher V.E. Wright Vanderbilt University
Qizhi Tang
Qizhi Tang University of California, San Francisco
Valerie M. Weaver
Valerie M. Weaver University of California, San Francisco
Jens T. Siveke
Jens T. Siveke German Cancer Research Center
Howard C. Crawford
Howard C. Crawford University of Michigan–Ann Arbor

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