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Biology and Biochemistry

D-Index
77
Citations
22478
World Ranking
4758
National Ranking
2302

Overview

Howard C. Crawford is affiliated with the University of Michigan-Ann Arbor in the United States and has contributed extensively to research in medicine, with a particular focus on oncology and molecular biology. Their work is primarily concentrated on pancreatic and hepatic oncology, epigenetics, cancer genomics, immune cell involvement in cancer, and cancer immunotherapy and biomarkers.

Their research spans several critical fields of study including:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

In subfields, their publications cover:

  • Oncology
  • Molecular Biology
  • Cancer Research
  • Immunology
  • Pulmonary and Respiratory Medicine

Some of the main topics addressed in their work are:

  • Pancreatic and Hepatic Oncology Research
  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics
  • Cancer Cells and Metastasis
  • Immune cells in cancer
  • Cancer, Hypoxia, and Metabolism
  • Cancer Immunotherapy and Biomarkers

Frequent publication venues for their research include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cellular and Molecular Gastroenterology and Hepatology
  • Clinical Cancer Research
  • Nature Communications

Notable recent papers by Howard C. Crawford include:

  • Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer, 2020, Nature Cancer
  • Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis, 2020, Cancer Discovery
  • Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer, 2021, Clinical Cancer Research
  • GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis, 2021, Nature Communications
  • Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1, 2021, Cancer Research

They have collaborated frequently with researchers such as Nina G. Steele, Marina Pasca di Magliano, Filip Bednar, Daniel James Salas-Escabillas, and Costas A. Lyssiotis, contributing to a broad network of scientific inquiry in related cancer and molecular biology domains.

Best Publications

  • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

    Sunil R. Hingorani;Emanuel F. Petricoin;Anirban Maitra;Vinodh Rajapakse

  • The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors

    Howard C. Crawford;Barbara M. Fingleton;Laura A. Rudolph-Owen;Kathleen J. Heppner Goss;Kathleen J. Heppner Goss

  • Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1

    Veerle Noë;Barbara Fingleton;Kathleen Jacobs;Howard C. Crawford

  • Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

    Ling Huang;Audrey Holtzinger;Ishaan Jagan;Michael Begora

  • Inhibition of RhoA by p120 catenin

    Panos Z. Anastasiadis;Sun Y. Moon;Molly A. Thoreson;Debbie J. Mariner

  • EGF Receptor is Required for KRAS-induced Pancreatic Tumorigenesis

    Christine M. Ardito;Barbara M. Grüner;Kenneth K. Takeuchi;Clara Lubeseder-Martellato

  • Matrix metalloproteinase-7–dependent release of tumor necrosis factor-α in a model of herniated disc resorption

    Hirotaka Haro;Howard C. Crawford;Barbara Fingleton;Kenichi Shinomiya

  • Osteopontin, a Novel Substrate for Matrix Metalloproteinase-3 (Stromelysin-1) and Matrix Metalloproteinase-7 (Matrilysin)

    Renu Agnihotri;Howard C. Crawford;Hirotaka Haro;Lynn M. Matrisian;Lynn M. Matrisian

  • The p120ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides

    Juliet M. Daniel;Christopher M. Spring;Howard C. Crawford;Albert B. Reynolds

  • Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer.

    Jami L. Saloman;Kathryn M. Albers;Dongjun Li;Douglas J. Hartman

  • NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer.

    Iok In Christine Chio;Iok In Christine Chio;Seyed Mehdi Jafarnejad;Mariano Ponz-Sarvise;Mariano Ponz-Sarvise;Youngkyu Park;Youngkyu Park

  • Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer

    Nina G. Steele;Eileen S. Carpenter;Samantha B. Kemp;Veerin R. Sirihorachai

  • Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.

    Christopher J. Halbrook;Corbin Pontious;Ilya Kovalenko;Laura Lapienyte

  • Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals

    C. T. Rubin;E. Capilla;Y. K. Luu;B. Busa

  • Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis.

    Yaqing Zhang;Jenny Lazarus;Nina G. Steele;Wei Yan

  • Loss of FOXA1/2 Is Essential for the Epithelial-to-Mesenchymal Transition in Pancreatic Cancer

    Yan Song;M. Kay Washington;Howard C. Crawford

  • Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs

    Geou Yarh Liou;Heike Döppler;Brian Necela;Murli Krishna

  • Tumor and stromal expression of matrix metalloproteinases and their role in tumor progression

    H. C. Crawford;L. M. Matrisian

  • Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas

    Howard C. Crawford;Charles R. Scoggins;M. Kay Washington;Lynn M. Matrisian

  • Mechanisms controlling the transcription of matrix metalloproteinase genes in normal and neoplastic cells.

    Howard C. Crawford;Lynn M. Matrisian

Frequent Co-Authors

Marina Pasca di Magliano
Marina Pasca di Magliano University of Michigan–Ann Arbor
Lynn M. Matrisian
Lynn M. Matrisian Vanderbilt University
Costas A. Lyssiotis
Costas A. Lyssiotis University of Michigan–Ann Arbor
Barbara Fingleton
Barbara Fingleton Vanderbilt University
Andrew V. Biankin
Andrew V. Biankin University of Glasgow
Peter J. Dempsey
Peter J. Dempsey University of Colorado Denver
David A. Tuveson
David A. Tuveson Cold Spring Harbor Laboratory
Jens T. Siveke
Jens T. Siveke German Cancer Research Center
Jennifer P. Morton
Jennifer P. Morton University of Glasgow
Owen J. Sansom
Owen J. Sansom University of Glasgow

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