World's Best Scientists 2026 revealed!
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Best Female Scientists
2025

D-Index & Metrics

Best Female Scientists

D-Index
111
Citations
61116
World Ranking
834
National Ranking
506

Medicine

D-Index
112
Citations
57298
World Ranking
5077
National Ranking
2748

Research.com Recognitions

  • 2025 - Research.com Best Female Scientists Award

Overview

Lynn M. Matrisian is affiliated with Vanderbilt University in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with a focus on Oncology and Cancer Research. The scientist's work intersects several specialized subfields including Pulmonary and Respiratory Medicine, Economics and Econometrics, and Molecular Biology.

Their scholarly output emphasizes topics related to Pancreatic and Hepatic Oncology Research, Cancer Genomics and Diagnostics, and Cancer Cells and Metastasis. Additional areas of investigation include Economic and Financial Impacts of Cancer, Neuroendocrine Tumor Research Advances, Metabolism, Diabetes, and Cancer, as well as Ethics in Clinical Research.

Lynn M. Matrisian has published numerous papers, with some notable examples being:

  • Estimated Projection of US Cancer Incidence and Death to 2040 (2021), JAMA Network Open
  • Overall survival in patients with pancreatic cancer receiving matched therapies following molecular profiling: a retrospective analysis of the Know Your Tumor registry trial (2020), The Lancet Oncology
  • Artificial Intelligence and Early Detection of Pancreatic Cancer (2021), Pancreas
  • Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma (2024), npj Precision Oncology
  • Early Detection Initiative: A randomized controlled trial of algorithm-based screening in patients with new onset hyperglycemia and diabetes for early detection of pancreatic ductal adenocarcinoma (2021), Contemporary Clinical Trials

The scientist frequently collaborates with other researchers, including Andrew Hendifar, Edik M. Blais, Emanuel F. Petricoin, Michael J. Pishvaian, and Sudheer Doss.

Publication venues where Lynn M. Matrisian has contributed repeatedly include the Journal of Clinical Oncology, Cancer Research, The Oncologist, Journal of Participatory Medicine, and the Journal of the National Comprehensive Cancer Network. The highest number of contributions appear in the Journal of Clinical Oncology and Cancer Research.

Best Publications

  • Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

    Lisa M. Coussens;Barbara Fingleton;Lynn M. Matrisian

  • Metalloproteinases and their inhibitors in matrix remodeling.

    Lynn M. Matrisian

  • Changing Views of the Role of Matrix Metalloproteinases in Metastasis

    Ann F. Chambers;Lynn M. Matrisian

  • Matrix Metalloproteinases: Biologic Activity and Clinical Implications

    Amy R. Nelson;Barbara Fingleton;Mace L. Rothenberg;Lynn M. Matrisian

  • The matrix-degrading metalloproteinases.

    Lynn M. Matrisian

  • The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research

    Martin A. Cheever;Martin A. Cheever;James P. Allison;Andrea S. Ferris;Olivera J. Finn

  • Matrix metalloproteinases: a tail of a frog that became a prince

    Constance E. Brinckerhoff;Lynn M. Matrisian

  • Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

    Li Yang;Laura M. DeBusk;Koari Fukuda;Barbara Fingleton

  • Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

    Carole L. Wilson;Andre J. Ouellette;Donald P. Satchell;Tokiyoshi Ayabe

  • Abrogation of TGFβ signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis

    Li Yang;Jianhua Huang;Xiubao Ren;Agnieszka E. Gorska

  • Emerging roles of proteases in tumour suppression

    Carlos López-Otín;Lynn M. Matrisian

  • The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors

    Howard C. Crawford;Barbara M. Fingleton;Laura A. Rudolph-Owen;Kathleen J. Heppner Goss;Kathleen J. Heppner Goss

  • Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.

    K. J. Heppner;L. M. Matrisian;R. A. Jensen;W. H. Rodgers

  • Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

    Carole L. Wilson;Kathleen J. Heppner;Patricia A. Labosky;Brigid L. M. Hogan

  • TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

    Lawrence D. Kerr;Donna B. Miller;Lynn M. Matrisian

  • Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis.

    John R. MacDougall;Lynn M. Matrisian

  • The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis

    William C. Powell;Barbara Fingleton;Carole L. Wilson;Mark Boothby

  • Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones.

    W H Rodgers;L M Matrisian;L C Giudice;B Dsupin

  • Matrix metalloproteinases in tumor–host cell communication

    Conor C. Lynch;Lynn M. Matrisian

  • Matrix metalloproteinase-7–dependent release of tumor necrosis factor-α in a model of herniated disc resorption

    Hirotaka Haro;Howard C. Crawford;Barbara Fingleton;Kenichi Shinomiya

Frequent Co-Authors

Barbara Fingleton
Barbara Fingleton Vanderbilt University
Howard C. Crawford
Howard C. Crawford University of Michigan–Ann Arbor
David W. Piston
David W. Piston Washington University in St. Louis
Richard Breathnach
Richard Breathnach Inserm : Institut national de la santé et de la recherche médicale
Yu Shyr
Yu Shyr Vanderbilt University Medical Center
David P. Carbone
David P. Carbone The Ohio State University
Bonnie F. Sloane
Bonnie F. Sloane Wayne State University
Emanuel F. Petricoin
Emanuel F. Petricoin George Mason University
Jonathan R. Brody
Jonathan R. Brody Thomas Jefferson University
Danny R. Welch
Danny R. Welch University of Kansas

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