2023 - Research.com Biology and Biochemistry in Canada Leader Award
2020 - Fellow of the Royal Society of Canada Academy of Science
2014 - Robert L. Noble Prize, Canadian Cancer Society
Internal medicine, Endocrinology, Matrix metalloproteinase, Extracellular matrix and Metastasis are his primary areas of study. He has researched Internal medicine in several fields, including Apoptosis and Programmed cell death. The Endocrinology study combines topics in areas such as Receptor, Cell cycle and Stem cell.
His Extracellular matrix research is classified as research in Cell biology. His Metastasis research is multidisciplinary, incorporating elements of Cancer cell, Melanoma, Immunology and Pathology. His Cancer cell research incorporates elements of Cancer research and Extravasation.
Rama Khokha spends much of his time researching Cancer research, Matrix metalloproteinase, Cell biology, Immunology and Internal medicine. His Cancer research research integrates issues from Carcinogenesis, Cancer, Breast cancer, Mammary gland and Phenotype. The concepts of his Matrix metalloproteinase study are interwoven with issues in Extracellular matrix, Genetically modified mouse, Metastasis and Pathology.
The study incorporates disciplines such as Cellular differentiation, Cell growth and Metalloproteinase in addition to Cell biology. His research investigates the connection between Immunology and topics such as Cell culture that intersect with problems in Molecular biology. As part of one scientific family, Rama Khokha deals mainly with the area of Internal medicine, narrowing it down to issues related to the Endocrinology, and often Inflammation.
Rama Khokha focuses on Cancer research, Progenitor cell, Cell biology, Stem cell and Breast cancer. His research in Cancer research intersects with topics in Cancer, Metastasis, Pancreatic cancer, Phenotype and Notch signaling pathway. His work focuses on many connections between Progenitor cell and other disciplines, such as Cell, that overlap with his field of interest in Mammary gland and Proteomics.
Rama Khokha combines subjects such as Stromal cell, Matrix metalloproteinase, Long bone and Fibroblast growth factor with his study of Cell biology. His Stem cell study frequently draws connections between adjacent fields such as Immunology. His study in the fields of Bone marrow under the domain of Immunology overlaps with other disciplines such as Ecological niche.
Rama Khokha mainly investigates Stem cell, Progenitor cell, Cell biology, Population and Cellular differentiation. The study of Stem cell is intertwined with the study of Cancer research in a number of ways. He focuses mostly in the field of Cancer research, narrowing it down to matters related to Notch signaling pathway and, in some cases, Osteosarcoma.
His Progenitor cell study combines topics from a wide range of disciplines, such as Cell, Epigenomics, DNA methylation and Proteomics. His work on Extracellular matrix as part of general Cell biology research is frequently linked to Context, thereby connecting diverse disciplines of science. His studies deal with areas such as Cell migration, Stromal cell, Morphogenesis and Mesenchymal stem cell as well as Cellular differentiation.
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Regulation of cancer cell migration and bone metastasis by RANKL
D. Holstead Jones;Tomoki Nakashima;Otto H. Sanchez;Otto H. Sanchez;Ivona Kozieradzki;Ivona Kozieradzki.
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development
Jimmie E Fata;Young-Yun Kong;Young-Yun Kong;Ji Li;Takehiko Sasaki.
Progesterone induces adult mammary stem cell expansion
Purna A. Joshi;Hartland W. Jackson;Alexander G. Beristain;Marco A. Di Grappa.
Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression
Isaac S. Harris;Aislinn E. Treloar;Satoshi Inoue;Masato Sasaki.
Cancer Cell (2015)
Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.
K J Leco;R Khokha;N Pavloff;S P Hawkes.
Journal of Biological Chemistry (1994)
Suppression of tumor growth and metastasis in Mgat5-deficient mice.
Maria Granovsky;Maria Granovsky;Jimmie Fata;Judy Pawling;William J. Muller.
Nature Medicine (2000)
Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells.
Rama Khokha;Paul Waterhouse;Simcha Yagel;Peeyush K. Lala.
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer.
Daniel Schramek;Andreas Leibbrandt;Verena Sigl;Lukas Kenner.
Metalloproteinases and their natural inhibitors in inflammation and immunity
Rama Khokha;Aditya Murthy;Ashley Weiss.
Nature Reviews Immunology (2013)
Tumor Necrosis Factor-α Mediates Cardiac Remodeling and Ventricular Dysfunction After Pressure Overload State
Mei Sun;Manyin Chen;Fayez Dawood;Urszula Zurawska.
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