World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
92
Citations
27267
World Ranking
2237
National Ranking
62

Medicine

D-Index
92
Citations
27438
World Ranking
11415
National Ranking
458

Research.com Recognitions

  • 2020 - Fellow of the Royal Society of Canada Academy of Science
  • 2014 - Robert L. Noble Prize, Canadian Cancer Society

Overview

Rama Khokha is affiliated with the Princess Margaret Cancer Centre in Canada and has contributed extensively to research in oncology, molecular biology, and medicine. Their work focuses on cancer biology, particularly pancreatic and hepatic oncology, cancer genomics, epigenetics, and immunology.

The scientist's recent publications illustrate key themes across tumor microenvironments, immune regulation, and cancer subtype differentiation. Notable papers include:

  • Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity, 2022, published in Immunity
  • Spatially confined sub-tumor microenvironments in pancreatic cancer, 2021, published in Cell
  • GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer, 2020, published in Clinical Cancer Research
  • A Four-Chemokine Signature Is Associated with a T-cell-Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer, 2020, published in Clinical Cancer Research
  • Modification of BRCA1-associated breast cancer risk by HMMR overexpression, 2022, published in Nature Communications

Frequent coauthors collaborating with Khokha include Barbara T. Grünwald, Curtis W. McCloskey, Kazeera Aliar, Thomas Kislinger, and Foram Vyas.

Khokha's publications appear regularly in certain venues, indicating a focus within those research communities. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Clinical Cancer Research
  • Nature Communications
  • British Journal of Cancer

The primary fields of study represented in Khokha's work cover Biochemistry, Genetics and Molecular Biology as well as Medicine. Subfields include:

  • Molecular Biology
  • Oncology
  • Cancer Research
  • Genetics
  • Immunology

Key research topics explored through Khokha's work are diverse and interconnected, focusing especially on cancer mechanisms and related cellular processes. These topics include:

  • Pancreatic and Hepatic Oncology Research
  • Epigenetics and DNA Methylation
  • Cancer Cells and Metastasis
  • Cancer Genomics and Diagnostics
  • Ubiquitin and proteasome pathways
  • Immune cells in cancer
  • Single-cell and spatial transcriptomics

Khokha has been recognized with awards including the Robert L. Noble Prize from the Canadian Cancer Society in 2014 and election as a Fellow of the Royal Society of Canada, Academy of Science, in 2020.

Best Publications

  • Regulation of cancer cell migration and bone metastasis by RANKL

    D. Holstead Jones;Tomoki Nakashima;Otto H. Sanchez;Otto H. Sanchez;Ivona Kozieradzki;Ivona Kozieradzki

  • The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

    Jimmie E Fata;Young-Yun Kong;Young-Yun Kong;Ji Li;Takehiko Sasaki

  • Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

    Isaac S. Harris;Aislinn E. Treloar;Satoshi Inoue;Masato Sasaki

  • Progesterone induces adult mammary stem cell expansion

    Purna A. Joshi;Hartland W. Jackson;Alexander G. Beristain;Marco A. Di Grappa

  • Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer.

    Daniel Schramek;Andreas Leibbrandt;Verena Sigl;Lukas Kenner

  • Suppression of tumor growth and metastasis in Mgat5-deficient mice.

    Maria Granovsky;Maria Granovsky;Jimmie Fata;Judy Pawling;William J. Muller

  • Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

    K J Leco;R Khokha;N Pavloff;S P Hawkes

  • Metalloproteinases and their natural inhibitors in inflammation and immunity

    Rama Khokha;Aditya Murthy;Ashley Weiss

  • Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells.

    Rama Khokha;Paul Waterhouse;Simcha Yagel;Peeyush K. Lala

  • Tumor Necrosis Factor-α Mediates Cardiac Remodeling and Ventricular Dysfunction After Pressure Overload State

    Mei Sun;Manyin Chen;Fayez Dawood;Urszula Zurawska

  • The Association of Measured Breast Tissue Characteristics with Mammographic Density and Other Risk Factors for Breast Cancer

    Tong Li;Limei Sun;Naomi Miller;Trudey Nicklee

  • TIMPs: versatile extracellular regulators in cancer

    Hartland W. Jackson;Hartland W. Jackson;Virginie Defamie;Paul Waterhouse;Rama Khokha

  • RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis

    Anne Hakem;Otto Sanchez-Sweatman;Annick You-Ten;Gordon Duncan

  • iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.

    David R. McIlwain;Philipp A. Lang;Philipp A. Lang;Thorsten Maretzky;Koichi Hamada

  • Molecular mechanisms of tumor invasion and metastasis: an integrated view.

    R. A. Cairns;R. Khokha;R. P. Hill

  • Steps in tumor metastasis: new concepts from intravital videomicroscopy.

    Ann F. Chambers;Ian C. MacDonald;Eric E. Schmidt;Sahadia Koop

  • Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution

    Susann Schenk;Edith Hintermann;Martin Bilban;Naohiko Koshikawa

  • Abnormal TNF activity in Timp3 −/− mice leads to chronic hepatic inflammation and failure of liver regeneration

    Fazilat F Mohammed;David S Smookler;Suzanne E M Taylor;Barbara Fingleton

  • Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3)

    Kevin J. Leco;Paul Waterhouse;Otto H. Sanchez;Katrina L.M. Gowing

  • Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development.

    C V Hojilla;F F Mohammed;R Khokha

Frequent Co-Authors

Josef M. Penninger
Josef M. Penninger University of British Columbia
Thomas Kislinger
Thomas Kislinger University of Toronto
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Dylan R. Edwards
Dylan R. Edwards University of East Anglia
Carl P. Blobel
Carl P. Blobel Cornell University
Ann F. Chambers
Ann F. Chambers University of Western Ontario
Paul C. Boutros
Paul C. Boutros University of California, Los Angeles
Andrew Wakeham
Andrew Wakeham Princess Margaret Cancer Centre
David T. Denhardt
David T. Denhardt Rutgers, The State University of New Jersey
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre

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