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Dominique Heymann

Dominique Heymann

D-Index & Metrics

Medicine

D-Index
82
Citations
22955
World Ranking
16202
National Ranking
532

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cancer
  • Internal medicine

Dominique Heymann spends much of his time researching Osteoclast, RANKL, Cancer research, Internal medicine and Osteosarcoma. His studies deal with areas such as Stromal cell, Bone cell, Biophysics, Bone remodeling and Resorption as well as Osteoclast. Dominique Heymann works mostly in the field of RANKL, limiting it down to topics relating to Osteoprotegerin and, in certain cases, Immunology and Osteolysis, as a part of the same area of interest.

His studies in Cancer research integrate themes in fields like Cytokine, Cell growth, Cancer cell, Apoptosis and Single-cell analysis. His study in Endocrinology extends to Internal medicine with its themes. His Osteosarcoma research is included under the broader classification of Pathology.

His most cited work include:

  • The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling. (470 citations)
  • Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite/β-tricalcium phosphate ratios (343 citations)
  • Induction of Osteogenesis in Mesenchymal Stem Cells by Activated Monocytes/Macrophages Depends on Oncostatin M Signaling (271 citations)

What are the main themes of his work throughout his whole career to date?

Dominique Heymann mainly investigates Cancer research, Osteosarcoma, Pathology, Internal medicine and RANKL. His Cancer research research is multidisciplinary, incorporating elements of Cell culture, Cancer cell, Immunology, Tumor progression and In vivo. His study in Osteosarcoma is interdisciplinary in nature, drawing from both Osteolysis, Cell growth, Metastasis, Sarcoma and Primary bone.

Dominique Heymann combines subjects such as Endocrinology and Oncology with his study of Internal medicine. He has included themes like Osteoclast and Osteoprotegerin in his RANKL study. Dominique Heymann interconnects Bone cell, Cell biology and Bone remodeling in the investigation of issues within Bone resorption.

He most often published in these fields:

  • Cancer research (49.30%)
  • Osteosarcoma (45.27%)
  • Pathology (25.35%)

What were the highlights of his more recent work (between 2017-2021)?

  • Osteosarcoma (45.27%)
  • Cancer research (49.30%)
  • Cancer (11.27%)

In recent papers he was focusing on the following fields of study:

Osteosarcoma, Cancer research, Cancer, Cancer cell and Internal medicine are his primary areas of study. His Osteosarcoma research integrates issues from Cell culture, Osteolysis, Mesenchymal stem cell and Sarcoma. His study looks at the relationship between Osteolysis and topics such as Bone remodeling, which overlap with Bone resorption.

His work deals with themes such as Chemotherapy, Metastasis, Circulating tumor cell, microRNA and In vivo, which intersect with Cancer research. His Internal medicine research is multidisciplinary, incorporating perspectives in Endocrinology and Oncology. RANKL is closely connected to Tumor microenvironment in his research, which is encompassed under the umbrella topic of Osteoprotegerin.

Between 2017 and 2021, his most popular works were:

  • The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma. (54 citations)
  • The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma. (54 citations)
  • The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma. (54 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Cancer
  • Internal medicine

Dominique Heymann focuses on Osteosarcoma, Disease, Cancer, Cancer research and Circulating tumor cell. His research integrates issues of Tumor microenvironment, Chondrosarcoma, Sarcoma and RANKL in his study of Osteosarcoma. His Disease study is concerned with Internal medicine in general.

His work on Cancer cell and Acquired resistance is typically connected to Multidrug tolerance as part of general Cancer study, connecting several disciplines of science. His Cancer cell study also includes

  • Extracellular matrix which is related to area like Immunology,
  • Immune system which intersects with area such as Bioinformatics, Bone healing, Bone resorption, Bone remodeling and Regeneration. His Cancer research study combines topics in areas such as Oral administration, Chemotherapy, Doxorubicin, Osteoclast and Tumor initiation.

Best Publications

  • The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling.

    Sandrine Theoleyre;Yohann Wittrant;Steeve Kwan Tat;Yannick Fortun

  • Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite/β-tricalcium phosphate ratios

    S Yamada;D Heymann;J M Bouler;G Daculsi

  • Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on Oncostatin M signaling

    P. Guihard;P. Guihard;Y. Danger;B. Brounais;B. Brounais;E. David;E. David

  • Human breast cancer cells educate macrophages toward the M2 activation status

    Sofia Sousa;Régis Brion;Régis Brion;Minnamaija Lintunen;Pauliina Kronqvist

  • Autophagy in osteoblasts is involved in mineralization and bone homeostasis.

    Marie Nollet;Sabine Santucci-Darmanin;Véronique Breuil;Rasha Al-Sahlanee

  • Mechanisms of bone repair and regeneration.

    Frédéric Deschaseaux;Luc Sensébé;Dominique Heymann

  • Recent advances in TGF-beta effects on chondrocyte metabolism. Potential therapeutic roles of TGF-beta in cartilage disorders.

    Eva Grimaud;Dominique Heymann;Françoise Rédini

  • Receptor Activator of Nuclear Factor κB Ligand (RANKL)/Osteoprotegerin (OPG) Ratio Is Increased in Severe Osteolysis

    Eva Grimaud;Luc Soubigou;Séverine Couillaud;Patrick Coipeau

  • Cancer stem cells in osteosarcoma

    Hannah K. Brown;Marta Tellez-Gabriel;Dominique Heymann;Dominique Heymann

  • RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis.

    Yohann Wittrant;Sandrine Théoleyre;Céline Chipoy;Marc Padrines

  • Osteoclastic acidification pathways during bone resorption.

    A.-V Rousselle;D Heymann

  • Current Therapeutic Strategies and Novel Approaches in Osteosarcoma

    Kosei Ando;Marie Françoise Heymann;Verena Stresing;Kanji Mori

  • gp130 Cytokine family and bone cells.

    Dominique Heymann;Anne-Valérie Rousselle

  • Sarcoma treatment in the era of molecular medicine

    Thomas G. P. Grunewald;Thomas G. P. Grunewald;Thomas G. P. Grunewald;Marta Alonso;Sofia Avnet;Ana Banito

  • Circulating Tumor Cells: A Review of Non–EpCAM-Based Approaches for Cell Enrichment and Isolation

    Marta Tellez Gabriel;Lidia Rodriguez Calleja;Lidia Rodriguez Calleja;Antoine Chalopin;Benjamin Ory;Benjamin Ory

  • RANKL, RANK, osteoprotegerin : key partners of osteoimmunology and vascular diseases

    M. Baud’huin;M. Baud’huin;F. Lamoureux;F. Lamoureux;L. Duplomb;L. Duplomb;F. Rédini;F. Rédini

  • The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma.

    Marie-Françoise Heymann;Frédéric Lézot;Dominique Heymann;Dominique Heymann;Dominique Heymann

  • Therapeutic Relevance of Osteoprotegerin Gene Therapy in Osteosarcoma: Blockade of the Vicious Cycle between Tumor Cell Proliferation and Bone Resorption

    François Lamoureux;Peggy Richard;Yohann Wittrant;Séverine Battaglia

  • Neointimal Hyperplasia after Stenting in a Human Mammary Artery Organ Culture

    P. Guérin;F. Rondeau;G. Grimandi;M.F. Heymann

  • Tumour heterogeneity: the key advantages of single-cell analysis

    Marta Tellez-Gabriel;Benjamin Ory;Francois Lamoureux;Marie-Francoise Heymann;Marie-Francoise Heymann

Frequent Co-Authors

Jérôme Guicheux
Jérôme Guicheux University of Nantes
Guy Daculsi
Guy Daculsi University of Nantes
Olivier Delattre
Olivier Delattre PSL University
James E. Bradner
James E. Bradner Amgen (United States)
Lisa Oliver
Lisa Oliver University of Nantes
Hideo Yagita
Hideo Yagita Juntendo University
Anne-Marie Fischer
Anne-Marie Fischer Université Paris Cité
Ez-Zoubir Amri
Ez-Zoubir Amri Grenoble Alpes University

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