World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
133
Citations
75396
World Ranking
371
National Ranking
244

Medicine

D-Index
132
Citations
73247
World Ranking
2297
National Ranking
1299

James E. Bradner publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where James E. Bradner sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 528 publications — 96th percentile

96% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

James E. Bradner D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where James E. Bradner sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 133 D-Index — 98th percentile

98% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

James E. Bradner is affiliated with Amgen in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans several subfields, including molecular biology, oncology, hematology, immunology, and neurology.

The primary focus of their work includes topics related to protein degradation and inhibitors, epigenetics and DNA methylation, CAR-T cell therapy research, ubiquitin and proteasome pathways, multiple myeloma research and treatments, peptidase inhibition and analysis, and genomics and chromatin dynamics.

James E. Bradner's recent publications showcase a range of studies primarily published between 2020 and 2021. Notable papers include:

  • "BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia," 2021, Journal of Clinical Investigation
  • "Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma," 2020, Journal of Clinical Investigation
  • "Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer," 2021, Science Advances
  • "Targeting oncoproteins with a positive selection assay for protein degraders," 2021, Science Advances
  • "An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity," 2020, Cell chemical biology

The scientist collaborates frequently with several coauthors, including Christopher J. Ott, Joshiawa Paulk, Jun Qi, Nathanael S. Gray, and Charles Y. Lin.

James E. Bradner's work is published predominantly in a few key venues. These venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Advances
  • Journal of Clinical Investigation
  • Cell chemical biology
  • JCI Insight

Best Publications

  • Selective inhibition of BET bromodomains.

    Panagis Filippakopoulos;Jun Qi;Sarah Picaud;Yao Shen

  • BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

    Jake E. Delmore;Ghayas C. Issa;Madeleine E. Lemieux;Peter B. Rahl

  • Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

    Jakob Lovén;Heather A. Hoke;Charles Y. Lin;Charles Y. Lin;Ashley Lau

  • RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

    Johannes Zuber;Junwei Shi;Junwei Shi;Eric Wang;Amy R. Rappaport;Amy R. Rappaport

  • HDAC2 negatively regulates memory formation and synaptic plasticity

    Ji Song Guan;Stephen J. Haggarty;Emanuela Giacometti;Jan Hermen Dannenberg;Jan Hermen Dannenberg

  • Transcriptional Amplification in Tumor Cells with Elevated c-Myc

    Charles Y. Lin;Jakob Lovén;Peter B. Rahl;Ronald M. Paranal

  • Phthalimide conjugation as a strategy for in vivo target protein degradation

    Georg E. Winter;Dennis L. Buckley;Joshiawa Paulk;Justin M. Roberts

  • The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

    Gang Lu;Richard E. Middleton;Huahang Sun;MarkVic Naniong

  • Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies

    Jayne M. Stommel;Alec C. Kimmelman;Haoqiang Ying;Roustem Nabioullin

  • Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90 A NOVEL BASIS FOR ANTILEUKEMIA ACTIVITY OF HISTONE DEACETYLASE INHIBITORS

    Purva Bali;Michael Pranpat;James Bradner;Maria Balasis

  • Transcriptional Addiction in Cancer

    James E. Bradner;Denes Hnisz;Richard A. Young

  • R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

    Rui Su;Lei Dong;Chenying Li;Sigrid Nachtergaele

  • Direct inhibition of the NOTCH transcription factor complex

    Raymond E. Moellering;Raymond E. Moellering;Melanie Cornejo;Tina N. Davis;Cristina Del Bianco

  • YY1 Is a Structural Regulator of Enhancer-Promoter Loops

    Abraham S. Weintraub;Charles H. Li;Alicia V. Zamudio;Alla A. Sigova

  • Chemical phylogenetics of histone deacetylases

    James E Bradner;Nathan West;Nathan West;Melissa L Grachan;Edward F Greenberg;Edward F Greenberg

  • PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models with EGFR and ERBB2 Mutations that Are Resistant to Gefitinib

    Jeffrey A. Engelman;Kreshnik Zejnullahu;Christopher Michael Gale;Eugene Lifshits

  • The dTAG system for immediate and target-specific protein degradation

    Behnam Nabet;Justin M. Roberts;Dennis L. Buckley;Dennis L. Buckley;Joshiawa Paulk;Joshiawa Paulk

  • Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma

    Bjoern Chapuy;Michael R. McKeown;Charles Y. Lin;Stefano Monti

  • Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.

    Teru Hideshima;James E. Bradner;Jason Wong;Dharminder Chauhan

  • A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia

    Stefan Gröschel;Stefan Gröschel;Mathijs A Sanders;Remco Hoogenboezem;Elzo de Wit

Frequent Co-Authors

Ralph Mazitschek
Ralph Mazitschek Harvard University
Andrew L. Kung
Andrew L. Kung Memorial Sloan Kettering Cancer Center
Nathanael S. Gray
Nathanael S. Gray Stanford University
Stuart L. Schreiber
Stuart L. Schreiber Harvard University
William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Scott A. Armstrong
Scott A. Armstrong Harvard University
Kwok-Kin Wong
Kwok-Kin Wong New York University
Constantine S. Mitsiades
Constantine S. Mitsiades Harvard University
Jon C. Aster
Jon C. Aster Harvard Medical School

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