Craig M. Crews

Overview

Best Publications

• Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation.

  Kathleen M. Sakamoto;Kyung B. Kim;Akiko Kumagai;Frank Mercurio

  1950
  Citations

• The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

  Craig M. Crews;Alessandro Alessandrini;Raymond L. Erikson

  1299
  Citations

• Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

  Lihao Meng;Royce Mohan;Benjamin H. B. Kwok;Mikael Elofsson

  1197
  Citations

• Induced protein degradation: an emerging drug discovery paradigm

  Ashton C. Lai;Craig M. Crews

  1159
  Citations

• Catalytic in vivo protein knockdown by small-molecule PROTACs

  Daniel P Bondeson;Alina Mares;Ian E D Smith;Eunhwa Ko

  1076
  Citations

• Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

  Jing Lu;Yimin Qian;Martha Altieri;Hanqing Dong

  1020
  Citations

• The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

  Ny Sin;Lihao Meng;Margaret Q. W. Wang;James J. Wen

  849
  Citations

• PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer.

  Kanak Raina;Jing Lu;Yimin Qian;Martha Altieri

  741
  Citations

• Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

  Daniel P. Bondeson;Blake E. Smith;George M. Burslem;Alexandru D. Buhimschi

  710
  Citations

• Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

  George M. Burslem;Craig M. Crews

  704
  Citations

• Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials

  Timothy W. Corson;Craig M. Crews

  688
  Citations

• Targeted protein degradation: expanding the toolbox.

  Matthieu Schapira;Matthieu Schapira;Matthew F Calabrese;Alex N Bullock;Craig M Crews

  663
  Citations

• The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase

  Benjamin H.B. Kwok;Brian Koh;MacKevin I. Ndubuisi;Mikael Elofsson

  662
  Citations

• PROteolysis TArgeting Chimeras (PROTACs) - Past, Present and Future

  Mariell Pettersson;Craig M. Crews

  636
  Citations

• The Ubiquitin-Proteasome Pathway and Proteasome Inhibitors

  Jayhyuk Myung;Kyung Bo Kim;Craig M. Crews

  617
  Citations

• Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

  Ashton C. Lai;Momar Toure;Doris Hellerschmied;Jemilat Salami

  596
  Citations

• Extracellular signals and reversible protein phosphorylation: What to Mek of it all

  Craig M. Crews;Raymond L. Erikson

  583
  Citations

• Small-Molecule PROTACS: New Approaches to Protein Degradation

  Momar Toure;Craig M. Crews

  576
  Citations

• The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study

  George M. Burslem;Blake E. Smith;Ashton C. Lai;Saul Jaime-Figueroa

  559
  Citations

• Structure of human methionine aminopeptidase-2 complexed with fumagillin.

  Shenping Liu;Joanne Widom;Christopher W. Kemp;Craig M. Crews

  549
  Citations