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Neuroscience

D-Index
57
Citations
10630
World Ranking
4374
National Ranking
1980

Overview

John J. Renger is affiliated with MSD in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and neuroscience. Their work spans several interconnected fields including molecular biology, experimental and cognitive psychology, psychiatry and mental health, cellular and molecular neuroscience, and cognitive neuroscience.

The scientist's primary research topics encompass receptor mechanisms and signaling, sleep and wakefulness research, sleep and related disorders, nicotinic acetylcholine receptors study, schizophrenia research and treatment, urinary bladder and prostate research, and metabolism and genetic disorders.

Frequent coauthors collaborating with John J. Renger include Sridhar Duvvuri, Ih Chang, Raymond Sanchez, Matthew Leoni, and David Gray.

They have published in a variety of scientific journals, with notable frequent venues being Neurology, IUPHAR/BPS Guide to Pharmacology CITE, The Lancet, Journal of Clinical Investigation, and International Journal of Molecular Sciences.

Recent significant papers include:

  • Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo-controlled, phase 1b trial (2022, The Lancet)
  • Parkinson disease among patients treated for benign prostatic hyperplasia with α1 adrenergic receptor antagonists (2021, Journal of Clinical Investigation)
  • A Comparative Study on the Lysosomal Cation Channel TMEM175 Using Automated Whole-Cell Patch-Clamp, Lysosomal Patch-Clamp, and Solid Supported Membrane-Based Electrophysiology: Functional Characterization and High-Throughput Screening Assay Development (2023, International Journal of Molecular Sciences)
  • PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [11C]MK-6884: Quantification with kinetic modeling and receptor occupancy by CVL-231 (emraclidine), a novel positive allosteric modulator (2024, Journal of Cerebral Blood Flow & Metabolism)
  • Orexin receptors in GtoPdb v.2021.3 (2021, IUPHAR/BPS Guide to Pharmacology CITE)

Best Publications

  • Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions.

    B A Stewart;H L Atwood;H L Atwood;J J Renger;J Wang

  • Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

    Christopher D. Cox;Michael J. Breslin;David B. Whitman;John D. Schreier

  • Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist

    Christopher J Winrow;Anthony L Gotter;Christopher D Cox;Scott M Doran

  • A Developmental Switch in Neurotransmitter Flux Enhances Synaptic Efficacy by Affecting AMPA Receptor Activation

    John J Renger;Christophe Egles;Guosong Liu

  • Essential Thalamic Contribution to Slow Waves of Natural Sleep

    François David;Joscha T. Schmiedt;Joscha T. Schmiedt;Hannah L. Taylor;Gergely Orban

  • Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells.

    Marija Usenovic;Shahriar Niroomand;Robert E. Drolet;Lihang Yao

  • Selective T-Type Calcium Channel Block in Thalamic Neurons Reveals Channel Redundancy and Physiological Impact of ITwindow

    Fanny M Dreyfus;Anne Tscherter;Adam C Errington;John J Renger

  • Presynaptic HCN1 channels regulate Cav3.2 activity and neurotransmission at select cortical synapses.

    Zhuo Huang;Rafael Lujan;Ivan Kadurin;Victor N Uebele

  • Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons.

    Megan O. Jacus;Victor N. Uebele;John J. Renger;Slobodan M. Todorovic

  • A sensitive aβ oligomer assay discriminates Alzheimer's and aged control cerebrospinal fluid.

    Mary J Savage;Juliya Kalinina;Abigail Wolfe;Katherine Tugusheva

  • International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin Receptor Function, Nomenclature and Pharmacology

    Anthony L. Gotter;Andrea L. Webber;Paul J. Coleman;John J. Renger

  • Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties

    Paul J. Coleman;John D. Schreier;Christopher D. Cox;Michael J. Breslin

  • Discovery and development of orexin receptor antagonists as therapeutics for insomnia

    C J Winrow;J J Renger

  • Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia.

    Christopher J. Winrow;Anthony L. Gotter;Christopher D. Cox;Pamela L. Tannenbaum

  • Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

    Jie Yin;Kerim Babaoglu;Chad A Brautigam;Lindsay Clark

  • Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist.

    William D. Shipe;James C. Barrow;Zhi Qiang Yang;Craig W. Lindsley;Craig W. Lindsley

  • The Discovery of Suvorexant, the First Orexin Receptor Drug for Insomnia

    Paul J. Coleman;Anthony L. Gotter;W. Joseph Herring;Christopher J. Winrow

  • Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.

    Jack D. Scott;Duane E. DeMong;Thomas J. Greshock;Kallol Basu

  • Calcineurin Signaling Mediates Activity-Dependent Relocation of the Axon Initial Segment

    Mark D. Evans;Rosanna P. Sammons;Sabrina Lebron;Adna S. Dumitrescu

  • Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities

    Guoping Fan;Christophe Egles;Yi Sun;Liliana Minichiello

  • Role of cAMP Cascade in Synaptic Stability and Plasticity: Ultrastructural and Physiological Analyses of Individual Synaptic Boutons in Drosophila Memory Mutants

    John J. Renger;Atsushi Ueda;Harold L. Atwood;Harold L. Atwood;C. K. Govind

Frequent Co-Authors

Jason M. Uslaner
Jason M. Uslaner MSD (United States)
Richard Hargreaves
Richard Hargreaves Harvard Medical School
Fred W. Turek
Fred W. Turek Northwestern University
Chun-Fang Wu
Chun-Fang Wu University of Iowa
Derk-Jan Dijk
Derk-Jan Dijk University of Surrey
Thomas S. Kilduff
Thomas S. Kilduff SRI International
Vincenzo Crunelli
Vincenzo Crunelli Cardiff University
Nathalie Leresche
Nathalie Leresche Sorbonne University
Thomas W. Rosahl
Thomas W. Rosahl MSD (United States)
Hee-Sup Shin
Hee-Sup Shin Institute for Basic Science

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