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Stephan J. Sigrist

Stephan J. Sigrist

D-Index & Metrics

Neuroscience

D-Index
77
Citations
21467
World Ranking
1838
National Ranking
166

Biology and Biochemistry

D-Index
77
Citations
21478
World Ranking
4777
National Ranking
352

Overview

Stephan J. Sigrist is affiliated with Freie Universität Berlin in Germany and has an extensive publication record primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Neuroscience. Their research spans several subfields including Cellular and Molecular Neuroscience, Molecular Biology, Cell Biology, Cognitive Neuroscience, and Pharmacology.

Their recent scholarly contributions include the following papers:

  • Dietary spermidine improves cognitive function, 2021, Cell Reports
  • eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction, 2021, Cell Reports
  • Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model, 2022, Journal of Neuroinflammation
  • Spermidine is essential for fasting-mediated autophagy and longevity, 2024, Nature Cell Biology
  • Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function, 2022, Science

Their work covers several main research topics, including Neurobiology and Insect Physiology Research, Cellular transport and secretion, Polyamine Metabolism and Applications, Neuroscience and Neuropharmacology Research, Retinal Development and Disorders, Photoreceptor and Optogenetics Research, and Lipid Membrane Structure and Behavior.

Stephan J. Sigrist frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), PLoS Biology, Current Biology, Nature Communications, and Cell Reports.

They have collaborated extensively with several co-authors, most notably Marta Maglione, Sheng Huang, Janine Lützkendorf, Torsten Götz, and Frank Madeo, reflecting ongoing research partnerships in related fields.

Best Publications

  • Oxygen stress: a regulator of apoptosis in yeast.

    Frank Madeo;Eleonore Fröhlich;Martin Ligr;Martin Grey

  • Cardioprotection and lifespan extension by the natural polyamine spermidine

    Tobias Eisenberg;Mahmoud Abdellatif;Sabrina Schroeder;Uwe Primessnig;Uwe Primessnig

  • A Caspase-Related Protease Regulates Apoptosis in Yeast.

    Frank Madeo;Eva Herker;Corinna Maldener;Silke Wissing

  • Bruchpilot, a Protein with Homology to ELKS/CAST, Is Required for Structural Integrity and Function of Synaptic Active Zones in Drosophila

    Dhananjay A. Wagh;Tobias M. Rasse;Esther Asan;Alois Hofbauer

  • Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release

    Robert J. Kittel;Carolin Wichmann;Tobias M. Rasse;Wernher Fouquet

  • Chronological aging leads to apoptosis in yeast

    Eva Herker;Helmut Jungwirth;Katharina A. Lehmann;Corinna Maldener

  • Drosophila fizzy-related Down-Regulates Mitotic Cyclins and Is Required for Cell Proliferation Arrest and Entry into Endocycles

    Stephan J Sigrist;Christian F Lehner

  • Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways

    N Minois;D Carmona-Gutierrez;M A Bauer;P Rockenfeller

  • Maturation of active zone assembly by Drosophila Bruchpilot

    Wernher Fouquet;David Owald;David Owald;Carolin Wichmann;Carolin Wichmann;Sara Mertel

  • An AIF orthologue regulates apoptosis in yeast

    Silke Wissing;Paula Ludovico;Eva Herker;Sabrina Buttner

  • Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.

    Varun K Gupta;Lisa Scheunemann;Tobias Eisenberg;Sara Mertel

  • Endonuclease G Regulates Budding Yeast Life and Death

    Sabrina Büttner;Tobias Eisenberg;Didac Carmona-Gutierrez;Doris Ruli

  • Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.

    S. Sigrist;H. Jacobs;R. Stratmann;C. F. Lehner

  • RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.

    Karen S. Y. Liu;Matthias Siebert;Sara Mertel;Elena Knoche

  • Protein scaffolds in the coupling of synaptic exocytosis and endocytosis

    Volker Haucke;Erwin Neher;Stephan J. Sigrist;Stephan J. Sigrist

  • Rapid activity-dependent modifications in synaptic structure and function require bidirectional Wnt signaling.

    Bulent Ataman;James A. Ashley;Michael Gorczyca;Preethi Ramachandran

  • Mutations in NSUN2 cause autosomal-recessive intellectual disability

    Lia Abbasi-Moheb;Sara Mertel;Melanie Gonsior;Leyla Nouri-Vahid

  • Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan.

    Tobias Eisenberg;Sabrina Schroeder;Aleksandra Andryushkova;Tobias Pendl

  • Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts

    Thierry Lorca;Anna Castro;Anne‐Marie Martinez;Suzanne Vigneron

  • Four different subunits are essential for expressing the synaptic glutamate receptor at neuromuscular junctions of Drosophila.

    Gang Qin;Tobias Schwarz;Robert J. Kittel;Andreas Schmid

Frequent Co-Authors

Frank Madeo
Frank Madeo University of Graz
Tobias Eisenberg
Tobias Eisenberg University of Graz
Didac Carmona-Gutierrez
Didac Carmona-Gutierrez University of Graz
Guido Kroemer
Guido Kroemer Université Paris Cité
Sabrina Büttner
Sabrina Büttner Stockholm University
Volker Haucke
Volker Haucke Freie Universität Berlin
Thomas R. Pieber
Thomas R. Pieber Medical University of Graz
Dietmar Schmitz
Dietmar Schmitz Charité - University Medicine Berlin
Markus C. Wahl
Markus C. Wahl Freie Universität Berlin
Stefan W. Hell
Stefan W. Hell Max Planck Society

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