World's Best Scientists 2026 revealed!

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Genetics

D-Index
125
Citations
51959
World Ranking
315
National Ranking
164

Molecular Biology

D-Index
125
Citations
51959
World Ranking
227
National Ranking
137

Research.com Recognitions

  • 2020 - Fellow of the American Academy of Arts and Sciences
  • 2020 - Member of the National Academy of Sciences

Overview

Hugo J. Bellen is affiliated with Baylor College of Medicine in the United States and has an extensive body of research primarily within the fields of biochemistry, genetics, and molecular biology. Their work spans diverse subfields including molecular biology, genetics, cell biology, physiology, and cellular and molecular neuroscience.

Their research covers a range of main topics such as genomics and rare diseases, genetics and neurodevelopmental disorders, mitochondrial function and pathology, cellular transport and secretion, genomic variations and chromosomal abnormalities, RNA modifications and cancer, and genetics, aging, and longevity in model organisms.

Frequent publication venues for Bellen's work include bioRxiv (Cold Spring Harbor Laboratory), The American Journal of Human Genetics, Genetics in Medicine, eLife, and Human Molecular Genetics.

Among recent papers, the following stand out:

  • "Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes," 2021, Proceedings of the National Academy of Sciences
  • "Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in Drosophila," 2020, Proceedings of the National Academy of Sciences
  • "Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms," 2020, Neuron
  • "Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution," 2023, Science
  • "An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination," 2022, eLife

Bellen has collaborated extensively with a number of researchers. Frequent co-authors include Oguz Kanca, Michael F. Wangler, Shinya Yamamoto, Lindsay C. Burrage, and Lauren C. Briere.

Their contributions to the scientific community have been recognized through awards such as being named a Fellow of the American Academy of Arts and Sciences in 2020, as well as becoming a Member of the National Academy of Sciences the same year.

Best Publications

  • Math1: an essential gene for the generation of inner ear hair cells.

    Nessan A. Bermingham;Bassem A. Hassan;Steven D. Price;Melissa A. Vollrath

  • The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes.

    Hugo J. Bellen;Robert W. Levis;Guochun Liao;Yuchun He

  • P[acman]: A BAC Transgenic Platform for Targeted Insertion of Large DNA Fragments in D. melanogaster

    Koen J. T. Venken;Yuchun He;Roger A. Hoskins;Hugo J. Bellen

  • Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions.

    Patrik Verstreken;Patrik Verstreken;Cindy V. Ly;Koen J.T. Venken;Tong Wey Koh

  • P-element-mediated enhancer detection: a versatile method to study development in Drosophila.

    Hugo J. Bellen;Cahir J. O'Kane;Clive Wilson;Ueli Grossniklaus

  • Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

    Lucy Liu;Ke Zhang;Hector Sandoval;Shinya Yamamoto;Shinya Yamamoto

  • Math1 is essential for genesis of cerebellar granule neurons.

    Nissim Ben-Arie;Hugo J. Bellen;Dawna L. Armstrong;Alanna E. McCall

  • MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes.

    Koen J T Venken;Karen L Schulze;Nele A Haelterman;Hongling Pan

  • Axon-Glia Interactions and the Domain Organization of Myelinated Axons Requires Neurexin IV/Caspr/Paranodin

    Manzoor A. Bhat;Jose C. Rios;Yue Lu;German P. Garcia-Fresco

  • A Cis-Regulatory Map of the Drosophila Genome

    Nicolas Nègre;Christopher D. Brown;Lijia Ma;Christopher Aaron Bristow

  • Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila.

    Riitta Nolo;Lois A Abbott;Hugo J Bellen

  • Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca2+-activated neurotransmitter release

    J.Troy Littleton;Michael Stern;Karen Schulze;Mark Perin

  • Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress.

    Yakov Pesah;Tuan Pham;Heather Burgess;Brooke Middlebrooks

  • 100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future

    Hugo J. Bellen;Chao Tong;Hiroshi Tsuda;Hiroshi Tsuda

  • Synaptic Vesicle Size and Number Are Regulated by a Clathrin Adaptor Protein Required for Endocytosis

    Bing Zhang;Bing Zhang;Young Ho Koh;Robert B Beckstead;Vivian Budnik

  • Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila

    Thomas E. Lloyd;Richard Atkinson;Mark N. Wu;Yi Zhou

  • Position Effects on Eukaryotic Gene Expression

    Clive Wilson;Hugo J. Bellen;Walter J. Gehring

  • A Drosophila Neurexin Is Required for Septate Junction and Blood-Nerve Barrier Formation and Function

    Stefan Baumgartner;J.Troy Littleton;Kendal Broadie;Manzoor A Bhat

  • P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila.

    Clive Wilson;Rebecca Kurth Pearson;Hugo J. Bellen;Cahir J. O'Kane

  • Drosophila tools and assays for the study of human diseases.

    Berrak Ugur;Kuchuan Chen;Hugo J. Bellen

Frequent Co-Authors

Michael F. Wangler
Michael F. Wangler Baylor College of Medicine
Huda Y. Zoghbi
Huda Y. Zoghbi Baylor College of Medicine
Brett H. Graham
Brett H. Graham Baylor College of Medicine
Jill A. Rosenfeld
Jill A. Rosenfeld Baylor College of Medicine
Norbert Perrimon
Norbert Perrimon Harvard University
Monte Westerfield
Monte Westerfield University of Oregon
John H. Postlethwait
John H. Postlethwait University of Oregon
Brendan Lee
Brendan Lee Baylor College of Medicine
Vandana Shashi
Vandana Shashi Duke University

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